Urinary macrophage migration inhibitory factor serves as a potential biomarker for acute kidney injury in patients with acute pyelonephritis

Ming-Yuan Hong, Chin-Chung Tseng, Chia-Chang Chuang, Chia-Ling Chen, Sheng-Hsiang Lin, Chiou Feng Lin

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Conventional markers of kidney function that are familiar to clinicians, including the serum creatinine and blood urea nitrogen levels, are unable to reveal genuine injury to the kidney, and their use may delay treatment. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine, and the predictive role and pathogenic mechanism of MIF deregulation during kidney infections involving acute kidney injury (AKI) are not currently known. In this study, we showed that elevated urinary MIF levels accompanied the development of AKI during kidney infection in patients with acute pyelonephritis (APN). In addition to the MIF level, the urinary levels of interleukin (IL)-1β and kidney injury molecule (KIM)-1 were also upregulated and were positively correlated with the levels of urinary MIF. An elevated urinary MIF level, along with elevated IL-1β and KIM-1 levels, is speculated to be a potential biomarker for the presence of AKI in APN patients.

Original languageEnglish
Article number381358
JournalMediators of Inflammation
Volume2012
DOIs
Publication statusPublished - 2012

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Macrophage Migration-Inhibitory Factors
Pyelonephritis
Acute Kidney Injury
Biomarkers
Kidney
Interleukin-1
Wounds and Injuries
Blood Urea Nitrogen
Infection
Creatinine
Cytokines
Serum

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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Urinary macrophage migration inhibitory factor serves as a potential biomarker for acute kidney injury in patients with acute pyelonephritis. / Hong, Ming-Yuan; Tseng, Chin-Chung; Chuang, Chia-Chang; Chen, Chia-Ling; Lin, Sheng-Hsiang; Lin, Chiou Feng.

In: Mediators of Inflammation, Vol. 2012, 381358, 2012.

Research output: Contribution to journalArticle

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AU - Lin, Chiou Feng

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