Urinary arsenic profiles and the risks of cancer mortality

A population-based 20-year follow-up study in arseniasis-endemic areas in Taiwan

Chi Jung Chung, Ya Li Huang, Yung Kai Huang, Meei Maan Wu, Shu Yuan Chen, Yu Mei Hsueh, Chien Jen Chen

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Few studies investigated the association between chronic arsenic exposure and the mortality of cancers by estimating individual urinary arsenic methylation profiles. Therefore, we compared with the general population in Taiwan to calculate the standardized mortality ratio (SMR) in arseniasis-endemic area of Taiwan from 1996 to 2010 and evaluated the dose-response relationships between environmental arsenic exposure indices or urinary arsenic profiles and the mortality of cause-specific cancer. A cohort of 1563 residents was conducted and collected their urine sample and information regarding arsenic exposure from a questionnaire. All-cause death was identified using the National Death Registry of Taiwan. Urinary arsenic profiles were measured using high performance liquid chromatography-hydride generator-atomic absorption spectrometry. We used Cox proportional hazard models to evaluate the mortality risks. In results, 193 all-site cancer deaths, and 29, 71, 43 deaths respectively for liver, lung and bladder cancers were ascertained. The SMRs were significantly high in arseniasis-endemic areas for liver, lung, and bladder cancers. People with high urinary InAs% or low DMA% or low secondary methylation index (SMI) were the most likely to suffer bladder cancer after adjusting other risk factors. Even stopping exposure to arsenic from the artesian well water, the mortality rates of the residents were higher than general population. Finally, urinary InAs%, DMA% and SMI could be the potential biomarkers to predict the mortality risk of bladder cancer.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalEnvironmental Research
Volume122
DOIs
Publication statusPublished - Apr 2013

Fingerprint

Arsenic
Taiwan
arsenic
cancer
mortality
Mortality
Urinary Bladder Neoplasms
Methylation
methylation
Population
Neoplasms
mortality risk
Dynamic mechanical analysis
Liver Neoplasms
Liver
Lung Neoplasms
Water Wells
artesian well
Atomic absorption spectrometry
dose-response relationship

Keywords

  • Cancer mortality
  • Cumulative arsenic exposure
  • Standardized mortality ratio
  • Urinary arsenic profile

ASJC Scopus subject areas

  • Environmental Science(all)
  • Biochemistry

Cite this

Urinary arsenic profiles and the risks of cancer mortality : A population-based 20-year follow-up study in arseniasis-endemic areas in Taiwan. / Chung, Chi Jung; Huang, Ya Li; Huang, Yung Kai; Wu, Meei Maan; Chen, Shu Yuan; Hsueh, Yu Mei; Chen, Chien Jen.

In: Environmental Research, Vol. 122, 04.2013, p. 25-30.

Research output: Contribution to journalArticle

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