Urinary arsenic profile affects the risk of urothelial carcinoma even at low arsenic exposure

Yeong Shiau Pu, Shu Mei Yang, Yung Kai Huang, Chi Jung Chung, Steven K. Huang, Wen-Hsiang Chiou, Mo Hsiung Yang, Chien Jen Chen, Yu Mei Hsueh

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Arsenic exposure is associated with an increased risk of urothelial carcinoma (UC). To explore the association between individual risk and urinary arsenic profile in subjects without evident exposure, 177 UC cases and 313 age-matched controls were recruited between September 2002 and May 2004 for a case-control study. Urinary arsenic species including the following three categories, inorganic arsenic (AsIII + AsV), monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV), were determined with high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Arsenic methylation profile was assessed by percentages of various arsenic species in the sum of the three categories measured. The primary methylation index (PMI) was defined as the ratio between MMAV and inorganic arsenic. Secondary methylation index (SMI) was determined as the ratio between DMAV and MMAV. Smoking is associated with a significant risk of UC in a dose-dependent manner. After multivariate adjustment, UC cases had a significantly higher sum of all the urinary species measured, higher percent MMAV, lower percent DMAV, higher PMI and lower SMI values compared with controls. Smoking interacts with the urinary arsenic profile in modifying the UC risk. Differential carcinogenic effects of the urinary arsenic profile, however, were seen more prominently in non-smokers than in smokers, suggesting that smoking is not the only major environmental source of arsenic contamination since the UC risk differs in non-smokers. Subjects who have an unfavorable urinary arsenic profile have an increased UC risk even at low exposure levels.

Original languageEnglish
Pages (from-to)99-106
Number of pages8
JournalToxicology and Applied Pharmacology
Volume218
Issue number2
DOIs
Publication statusPublished - Jan 15 2007

Fingerprint

Arsenic
Carcinoma
Methylation
Smoking
Cacodylic Acid
Social Adjustment
Atomic absorption spectrometry
High performance liquid chromatography
Hydrides
Case-Control Studies
Spectrum Analysis
Contamination
High Pressure Liquid Chromatography
Association reactions

Keywords

  • Bladder neoplasms
  • Carcinogenesis
  • Contamination
  • Synergy
  • Tobacco

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Urinary arsenic profile affects the risk of urothelial carcinoma even at low arsenic exposure. / Pu, Yeong Shiau; Yang, Shu Mei; Huang, Yung Kai; Chung, Chi Jung; Huang, Steven K.; Chiou, Wen-Hsiang; Yang, Mo Hsiung; Chen, Chien Jen; Hsueh, Yu Mei.

In: Toxicology and Applied Pharmacology, Vol. 218, No. 2, 15.01.2007, p. 99-106.

Research output: Contribution to journalArticle

Pu, YS, Yang, SM, Huang, YK, Chung, CJ, Huang, SK, Chiou, W-H, Yang, MH, Chen, CJ & Hsueh, YM 2007, 'Urinary arsenic profile affects the risk of urothelial carcinoma even at low arsenic exposure', Toxicology and Applied Pharmacology, vol. 218, no. 2, pp. 99-106. https://doi.org/10.1016/j.taap.2006.09.021
Pu, Yeong Shiau ; Yang, Shu Mei ; Huang, Yung Kai ; Chung, Chi Jung ; Huang, Steven K. ; Chiou, Wen-Hsiang ; Yang, Mo Hsiung ; Chen, Chien Jen ; Hsueh, Yu Mei. / Urinary arsenic profile affects the risk of urothelial carcinoma even at low arsenic exposure. In: Toxicology and Applied Pharmacology. 2007 ; Vol. 218, No. 2. pp. 99-106.
@article{170637b342114213b508fd33c1eef90b,
title = "Urinary arsenic profile affects the risk of urothelial carcinoma even at low arsenic exposure",
abstract = "Arsenic exposure is associated with an increased risk of urothelial carcinoma (UC). To explore the association between individual risk and urinary arsenic profile in subjects without evident exposure, 177 UC cases and 313 age-matched controls were recruited between September 2002 and May 2004 for a case-control study. Urinary arsenic species including the following three categories, inorganic arsenic (AsIII + AsV), monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV), were determined with high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Arsenic methylation profile was assessed by percentages of various arsenic species in the sum of the three categories measured. The primary methylation index (PMI) was defined as the ratio between MMAV and inorganic arsenic. Secondary methylation index (SMI) was determined as the ratio between DMAV and MMAV. Smoking is associated with a significant risk of UC in a dose-dependent manner. After multivariate adjustment, UC cases had a significantly higher sum of all the urinary species measured, higher percent MMAV, lower percent DMAV, higher PMI and lower SMI values compared with controls. Smoking interacts with the urinary arsenic profile in modifying the UC risk. Differential carcinogenic effects of the urinary arsenic profile, however, were seen more prominently in non-smokers than in smokers, suggesting that smoking is not the only major environmental source of arsenic contamination since the UC risk differs in non-smokers. Subjects who have an unfavorable urinary arsenic profile have an increased UC risk even at low exposure levels.",
keywords = "Bladder neoplasms, Carcinogenesis, Contamination, Synergy, Tobacco",
author = "Pu, {Yeong Shiau} and Yang, {Shu Mei} and Huang, {Yung Kai} and Chung, {Chi Jung} and Huang, {Steven K.} and Wen-Hsiang Chiou and Yang, {Mo Hsiung} and Chen, {Chien Jen} and Hsueh, {Yu Mei}",
year = "2007",
month = "1",
day = "15",
doi = "10.1016/j.taap.2006.09.021",
language = "English",
volume = "218",
pages = "99--106",
journal = "Toxicology and Applied Pharmacology",
issn = "0041-008X",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Urinary arsenic profile affects the risk of urothelial carcinoma even at low arsenic exposure

AU - Pu, Yeong Shiau

AU - Yang, Shu Mei

AU - Huang, Yung Kai

AU - Chung, Chi Jung

AU - Huang, Steven K.

AU - Chiou, Wen-Hsiang

AU - Yang, Mo Hsiung

AU - Chen, Chien Jen

AU - Hsueh, Yu Mei

PY - 2007/1/15

Y1 - 2007/1/15

N2 - Arsenic exposure is associated with an increased risk of urothelial carcinoma (UC). To explore the association between individual risk and urinary arsenic profile in subjects without evident exposure, 177 UC cases and 313 age-matched controls were recruited between September 2002 and May 2004 for a case-control study. Urinary arsenic species including the following three categories, inorganic arsenic (AsIII + AsV), monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV), were determined with high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Arsenic methylation profile was assessed by percentages of various arsenic species in the sum of the three categories measured. The primary methylation index (PMI) was defined as the ratio between MMAV and inorganic arsenic. Secondary methylation index (SMI) was determined as the ratio between DMAV and MMAV. Smoking is associated with a significant risk of UC in a dose-dependent manner. After multivariate adjustment, UC cases had a significantly higher sum of all the urinary species measured, higher percent MMAV, lower percent DMAV, higher PMI and lower SMI values compared with controls. Smoking interacts with the urinary arsenic profile in modifying the UC risk. Differential carcinogenic effects of the urinary arsenic profile, however, were seen more prominently in non-smokers than in smokers, suggesting that smoking is not the only major environmental source of arsenic contamination since the UC risk differs in non-smokers. Subjects who have an unfavorable urinary arsenic profile have an increased UC risk even at low exposure levels.

AB - Arsenic exposure is associated with an increased risk of urothelial carcinoma (UC). To explore the association between individual risk and urinary arsenic profile in subjects without evident exposure, 177 UC cases and 313 age-matched controls were recruited between September 2002 and May 2004 for a case-control study. Urinary arsenic species including the following three categories, inorganic arsenic (AsIII + AsV), monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV), were determined with high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Arsenic methylation profile was assessed by percentages of various arsenic species in the sum of the three categories measured. The primary methylation index (PMI) was defined as the ratio between MMAV and inorganic arsenic. Secondary methylation index (SMI) was determined as the ratio between DMAV and MMAV. Smoking is associated with a significant risk of UC in a dose-dependent manner. After multivariate adjustment, UC cases had a significantly higher sum of all the urinary species measured, higher percent MMAV, lower percent DMAV, higher PMI and lower SMI values compared with controls. Smoking interacts with the urinary arsenic profile in modifying the UC risk. Differential carcinogenic effects of the urinary arsenic profile, however, were seen more prominently in non-smokers than in smokers, suggesting that smoking is not the only major environmental source of arsenic contamination since the UC risk differs in non-smokers. Subjects who have an unfavorable urinary arsenic profile have an increased UC risk even at low exposure levels.

KW - Bladder neoplasms

KW - Carcinogenesis

KW - Contamination

KW - Synergy

KW - Tobacco

UR - http://www.scopus.com/inward/record.url?scp=33846588434&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846588434&partnerID=8YFLogxK

U2 - 10.1016/j.taap.2006.09.021

DO - 10.1016/j.taap.2006.09.021

M3 - Article

C2 - 17196235

AN - SCOPUS:33846588434

VL - 218

SP - 99

EP - 106

JO - Toxicology and Applied Pharmacology

JF - Toxicology and Applied Pharmacology

SN - 0041-008X

IS - 2

ER -