Uric acid level as a risk marker for metabolic syndrome: A Chinese cohort study

Tsan Yang; Chi Hong Chu; Chyi Huey Bai; San Lin You; Yu Ching Chou; Wan Yun Chou; Kuo Liong Chien; Lee Ching Hwang; Ta Chen Su; Chin Hsiao Tseng; Chien An Sun

doi:10.1016/j.atherosclerosis.2011.11.014

Uric acid level as a risk marker for metabolic syndrome: A Chinese cohort study

Tsan Yang, Chi Hong Chu, Chyi Huey Bai, San Lin You, Yu Ching Chou, Wan Yun Chou, Kuo Liong Chien, Lee Ching Hwang, Ta Chen Su, Chin Hsiao Tseng, Chien An Sun

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Abstract

Objective: Despite some epidemiologic research demonstrating a positive relationship between serum uric acid (SUA) levels and the prevalence of metabolic syndrome (MetS), prospective data on SUA as a predictor of MetS incidence are limited. Methods: The authors examined SUA as a risk marker for incident MetS in a prospective study of 3857 subjects who were free of MetS at baseline recruitment. Hyperuricemia was defined as SUA ≥7.7. mg/dL for men and ≥6.6. mg/dL for women. The MetS was defined according to a unified criteria set by several major organizations. Results: During a mean follow-up of 5.41 years, 476 participants developed MetS. A significantly stepwise increase in the incidence of MetS across tertiles of SUA was observed in the whole group (p for trend

Original language	English
Pages (from-to)	525-531
Number of pages	7
Journal	Atherosclerosis
Volume	220
Issue number	2
DOIs	https://doi.org/10.1016/j.atherosclerosis.2011.11.014
Publication status	Published - Feb 2012

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Keywords

Cohort study
Hyperuricemia
Metabolic syndrome
Uric acid

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Cite this

Yang, T., Chu, C. H., Bai, C. H., You, S. L., Chou, Y. C., Chou, W. Y., Chien, K. L., Hwang, L. C., Su, T. C., Tseng, C. H., & Sun, C. A. (2012). Uric acid level as a risk marker for metabolic syndrome: A Chinese cohort study. Atherosclerosis, 220(2), 525-531. https://doi.org/10.1016/j.atherosclerosis.2011.11.014

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abstract = "Objective: Despite some epidemiologic research demonstrating a positive relationship between serum uric acid (SUA) levels and the prevalence of metabolic syndrome (MetS), prospective data on SUA as a predictor of MetS incidence are limited. Methods: The authors examined SUA as a risk marker for incident MetS in a prospective study of 3857 subjects who were free of MetS at baseline recruitment. Hyperuricemia was defined as SUA ≥7.7. mg/dL for men and ≥6.6. mg/dL for women. The MetS was defined according to a unified criteria set by several major organizations. Results: During a mean follow-up of 5.41 years, 476 participants developed MetS. A significantly stepwise increase in the incidence of MetS across tertiles of SUA was observed in the whole group (p for trend ",

keywords = "Cohort study, Hyperuricemia, Metabolic syndrome, Uric acid",

author = "Tsan Yang and Chu, {Chi Hong} and Bai, {Chyi Huey} and You, {San Lin} and Chou, {Yu Ching} and Chou, {Wan Yun} and Chien, {Kuo Liong} and Hwang, {Lee Ching} and Su, {Ta Chen} and Tseng, {Chin Hsiao} and Sun, {Chien An}",

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AU - You, San Lin

AU - Chou, Yu Ching

AU - Chou, Wan Yun

AU - Chien, Kuo Liong

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AU - Su, Ta Chen

AU - Tseng, Chin Hsiao

AU - Sun, Chien An

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AB - Objective: Despite some epidemiologic research demonstrating a positive relationship between serum uric acid (SUA) levels and the prevalence of metabolic syndrome (MetS), prospective data on SUA as a predictor of MetS incidence are limited. Methods: The authors examined SUA as a risk marker for incident MetS in a prospective study of 3857 subjects who were free of MetS at baseline recruitment. Hyperuricemia was defined as SUA ≥7.7. mg/dL for men and ≥6.6. mg/dL for women. The MetS was defined according to a unified criteria set by several major organizations. Results: During a mean follow-up of 5.41 years, 476 participants developed MetS. A significantly stepwise increase in the incidence of MetS across tertiles of SUA was observed in the whole group (p for trend

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10.1016/j.atherosclerosis.2011.11.014