Uric acid level as a risk marker for metabolic syndrome: A Chinese cohort study

Tsan Yang, Chi Hong Chu, Chyi Huey Bai, San Lin You, Yu Ching Chou, Wan Yun Chou, Kuo Liong Chien, Lee Ching Hwang, Ta Chen Su, Chin Hsiao Tseng, Chien An Sun

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Abstract

Objective: Despite some epidemiologic research demonstrating a positive relationship between serum uric acid (SUA) levels and the prevalence of metabolic syndrome (MetS), prospective data on SUA as a predictor of MetS incidence are limited. Methods: The authors examined SUA as a risk marker for incident MetS in a prospective study of 3857 subjects who were free of MetS at baseline recruitment. Hyperuricemia was defined as SUA ≥7.7. mg/dL for men and ≥6.6. mg/dL for women. The MetS was defined according to a unified criteria set by several major organizations. Results: During a mean follow-up of 5.41 years, 476 participants developed MetS. A significantly stepwise increase in the incidence of MetS across tertiles of SUA was observed in the whole group (p for trend

Original languageEnglish
Pages (from-to)525-531
Number of pages7
JournalAtherosclerosis
Volume220
Issue number2
DOIs
Publication statusPublished - Feb 2012

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Keywords

  • Cohort study
  • Hyperuricemia
  • Metabolic syndrome
  • Uric acid

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Yang, T., Chu, C. H., Bai, C. H., You, S. L., Chou, Y. C., Chou, W. Y., Chien, K. L., Hwang, L. C., Su, T. C., Tseng, C. H., & Sun, C. A. (2012). Uric acid level as a risk marker for metabolic syndrome: A Chinese cohort study. Atherosclerosis, 220(2), 525-531. https://doi.org/10.1016/j.atherosclerosis.2011.11.014