Abstract
Objective: Despite some epidemiologic research demonstrating a positive relationship between serum uric acid (SUA) levels and the prevalence of metabolic syndrome (MetS), prospective data on SUA as a predictor of MetS incidence are limited. Methods: The authors examined SUA as a risk marker for incident MetS in a prospective study of 3857 subjects who were free of MetS at baseline recruitment. Hyperuricemia was defined as SUA ≥7.7. mg/dL for men and ≥6.6. mg/dL for women. The MetS was defined according to a unified criteria set by several major organizations. Results: During a mean follow-up of 5.41 years, 476 participants developed MetS. A significantly stepwise increase in the incidence of MetS across tertiles of SUA was observed in the whole group (p for trend
Original language | English |
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Pages (from-to) | 525-531 |
Number of pages | 7 |
Journal | Atherosclerosis |
Volume | 220 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2012 |
Keywords
- Cohort study
- Hyperuricemia
- Metabolic syndrome
- Uric acid
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine