Uric acid concentration as a risk marker for blood pressure progression and incident hypertension

A Chinese cohort study

Tsan Yang, Chi Hong Chu, Chyi Huey Bai, San Lin You, Yu Ching Chou, Lee Ching Hwang, Kuo Liong Chien, Ta Chen Su, Chin Hsiao Tseng, Chien An Sun

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Objective: Little is known about serum uric acid (SUA) role for hypertension in the Asian countries with low cardiovascular events. We aimed to explore the relationship in a comprehensive Chinese cohort. Methods: Participants in the Taiwanese Survey on Prevalences of Hypertension, Hyperglycemia, and Hyperlipidemia (TwSHHH) who were free of hypertension at baseline recruitment in 2002 (n= 3257) were evaluated for the longitudinal association between baseline SUA and blood pressure progression (BPP) and incident hypertension. Results: During a mean follow-up of 5.41 years, 1119 persons (34.3%) had experienced progression to a higher blood pressure stage and 496 persons (15.2%) had developed hypertension. In multivariate analyses, the adjusted hazard ratios (HRs) [95% confidence intervals (CIs)] comparing the highest and lowest SUA quartiles were 1.78 (1.11-2.02, P for trend.004) for BPP and 1.68 (1.23-2.04, P for trend.028) for incident hypertension. The positively graded relationships between SUA concentration and blood pressure outcomes were observed in both males and females. More interestingly, a statistically significant trend for increasing risk of BPP and incident hypertension across SUA quartiles was most pronounced in participants with abdominal obesity. Conclusion: We concluded that SUA level was an independent predictor of blood pressure progression and incident hypertension in a Chinese population.

Original languageEnglish
Pages (from-to)1747-1755
Number of pages9
JournalMetabolism: Clinical and Experimental
Volume61
Issue number12
DOIs
Publication statusPublished - Dec 2012

Fingerprint

Uric Acid
Cohort Studies
Blood Pressure
Hypertension
Serum
Abdominal Obesity
Hyperlipidemias
Hyperglycemia
Multivariate Analysis
Confidence Intervals
Population

Keywords

  • Abdominal obesity
  • Longitudinal study
  • Serum uric acid

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Uric acid concentration as a risk marker for blood pressure progression and incident hypertension : A Chinese cohort study. / Yang, Tsan; Chu, Chi Hong; Bai, Chyi Huey; You, San Lin; Chou, Yu Ching; Hwang, Lee Ching; Chien, Kuo Liong; Su, Ta Chen; Tseng, Chin Hsiao; Sun, Chien An.

In: Metabolism: Clinical and Experimental, Vol. 61, No. 12, 12.2012, p. 1747-1755.

Research output: Contribution to journalArticle

Yang, Tsan ; Chu, Chi Hong ; Bai, Chyi Huey ; You, San Lin ; Chou, Yu Ching ; Hwang, Lee Ching ; Chien, Kuo Liong ; Su, Ta Chen ; Tseng, Chin Hsiao ; Sun, Chien An. / Uric acid concentration as a risk marker for blood pressure progression and incident hypertension : A Chinese cohort study. In: Metabolism: Clinical and Experimental. 2012 ; Vol. 61, No. 12. pp. 1747-1755.
@article{1912bcda0f264905a80af85fdd7e091b,
title = "Uric acid concentration as a risk marker for blood pressure progression and incident hypertension: A Chinese cohort study",
abstract = "Objective: Little is known about serum uric acid (SUA) role for hypertension in the Asian countries with low cardiovascular events. We aimed to explore the relationship in a comprehensive Chinese cohort. Methods: Participants in the Taiwanese Survey on Prevalences of Hypertension, Hyperglycemia, and Hyperlipidemia (TwSHHH) who were free of hypertension at baseline recruitment in 2002 (n= 3257) were evaluated for the longitudinal association between baseline SUA and blood pressure progression (BPP) and incident hypertension. Results: During a mean follow-up of 5.41 years, 1119 persons (34.3{\%}) had experienced progression to a higher blood pressure stage and 496 persons (15.2{\%}) had developed hypertension. In multivariate analyses, the adjusted hazard ratios (HRs) [95{\%} confidence intervals (CIs)] comparing the highest and lowest SUA quartiles were 1.78 (1.11-2.02, P for trend.004) for BPP and 1.68 (1.23-2.04, P for trend.028) for incident hypertension. The positively graded relationships between SUA concentration and blood pressure outcomes were observed in both males and females. More interestingly, a statistically significant trend for increasing risk of BPP and incident hypertension across SUA quartiles was most pronounced in participants with abdominal obesity. Conclusion: We concluded that SUA level was an independent predictor of blood pressure progression and incident hypertension in a Chinese population.",
keywords = "Abdominal obesity, Longitudinal study, Serum uric acid",
author = "Tsan Yang and Chu, {Chi Hong} and Bai, {Chyi Huey} and You, {San Lin} and Chou, {Yu Ching} and Hwang, {Lee Ching} and Chien, {Kuo Liong} and Su, {Ta Chen} and Tseng, {Chin Hsiao} and Sun, {Chien An}",
year = "2012",
month = "12",
doi = "10.1016/j.metabol.2012.05.006",
language = "English",
volume = "61",
pages = "1747--1755",
journal = "Metabolism: Clinical and Experimental",
issn = "0026-0495",
publisher = "W.B. Saunders Ltd",
number = "12",

}

TY - JOUR

T1 - Uric acid concentration as a risk marker for blood pressure progression and incident hypertension

T2 - A Chinese cohort study

AU - Yang, Tsan

AU - Chu, Chi Hong

AU - Bai, Chyi Huey

AU - You, San Lin

AU - Chou, Yu Ching

AU - Hwang, Lee Ching

AU - Chien, Kuo Liong

AU - Su, Ta Chen

AU - Tseng, Chin Hsiao

AU - Sun, Chien An

PY - 2012/12

Y1 - 2012/12

N2 - Objective: Little is known about serum uric acid (SUA) role for hypertension in the Asian countries with low cardiovascular events. We aimed to explore the relationship in a comprehensive Chinese cohort. Methods: Participants in the Taiwanese Survey on Prevalences of Hypertension, Hyperglycemia, and Hyperlipidemia (TwSHHH) who were free of hypertension at baseline recruitment in 2002 (n= 3257) were evaluated for the longitudinal association between baseline SUA and blood pressure progression (BPP) and incident hypertension. Results: During a mean follow-up of 5.41 years, 1119 persons (34.3%) had experienced progression to a higher blood pressure stage and 496 persons (15.2%) had developed hypertension. In multivariate analyses, the adjusted hazard ratios (HRs) [95% confidence intervals (CIs)] comparing the highest and lowest SUA quartiles were 1.78 (1.11-2.02, P for trend.004) for BPP and 1.68 (1.23-2.04, P for trend.028) for incident hypertension. The positively graded relationships between SUA concentration and blood pressure outcomes were observed in both males and females. More interestingly, a statistically significant trend for increasing risk of BPP and incident hypertension across SUA quartiles was most pronounced in participants with abdominal obesity. Conclusion: We concluded that SUA level was an independent predictor of blood pressure progression and incident hypertension in a Chinese population.

AB - Objective: Little is known about serum uric acid (SUA) role for hypertension in the Asian countries with low cardiovascular events. We aimed to explore the relationship in a comprehensive Chinese cohort. Methods: Participants in the Taiwanese Survey on Prevalences of Hypertension, Hyperglycemia, and Hyperlipidemia (TwSHHH) who were free of hypertension at baseline recruitment in 2002 (n= 3257) were evaluated for the longitudinal association between baseline SUA and blood pressure progression (BPP) and incident hypertension. Results: During a mean follow-up of 5.41 years, 1119 persons (34.3%) had experienced progression to a higher blood pressure stage and 496 persons (15.2%) had developed hypertension. In multivariate analyses, the adjusted hazard ratios (HRs) [95% confidence intervals (CIs)] comparing the highest and lowest SUA quartiles were 1.78 (1.11-2.02, P for trend.004) for BPP and 1.68 (1.23-2.04, P for trend.028) for incident hypertension. The positively graded relationships between SUA concentration and blood pressure outcomes were observed in both males and females. More interestingly, a statistically significant trend for increasing risk of BPP and incident hypertension across SUA quartiles was most pronounced in participants with abdominal obesity. Conclusion: We concluded that SUA level was an independent predictor of blood pressure progression and incident hypertension in a Chinese population.

KW - Abdominal obesity

KW - Longitudinal study

KW - Serum uric acid

UR - http://www.scopus.com/inward/record.url?scp=84869509279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869509279&partnerID=8YFLogxK

U2 - 10.1016/j.metabol.2012.05.006

DO - 10.1016/j.metabol.2012.05.006

M3 - Article

VL - 61

SP - 1747

EP - 1755

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

SN - 0026-0495

IS - 12

ER -