Urban air pollution increases plasma fibrinogen and plasminogen activator inhibitor-1 levels in susceptible patients

Ta Chen Su, Chang Chuan Chan, Chiau Suong Liau, Lian Yu Lin, Hsian Li Kao, Kai Jen Chuang

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

BACKGROUND: The cardiovascular effects on fibrinolytic activity by urban air pollution are still unknown. METHODS: Paired fasting blood samples during high and low air pollution days in Taipei were taken from a panel of 49 patients with coronary heart disease or multiple risk factors to study their fibrinolytic and inflammatory response to urban air pollution. Paired t-tests and mixed-effects models were used to determine the air pollution effects. RESULTS: Patients' plasma plasminogen activator inhibitor-1 levels were significantly increased when hourly concentrations of particulate matter with diameters less than 10 μm (PM10) were greater than 100 μg/m during the period 0800 to 1800 h. CONCLUSION: Urban air pollution has an adverse effect on plasma fibrinolytic function in a susceptible population.

Original languageEnglish
Pages (from-to)849-852
Number of pages4
JournalEuropean Journal of Cardiovascular Prevention and Rehabilitation
Volume13
Issue number5
DOIs
Publication statusPublished - Oct 2006
Externally publishedYes

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Keywords

  • Fibrinogen
  • Inflammation marker
  • Particulate matter
  • Plasminogen activator inhibitor-1
  • Urban air pollution

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Rehabilitation
  • Public Health, Environmental and Occupational Health

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