Upregulation of fecal cytokeratin 19 is associated with prognosis in older colorectal cancer patients

Ruey Neng Yang, Shung Haur Yang, Chun Chao Chang, Chih Cheng Chien, Shiann Pan, Chi Jung Huang

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8 Citations (Scopus)

Abstract

The upregulation of fecal cytokeratin 19 (CK19) correlates with age and metastatic status in human colorectal cancer (CRC). To further explore its clinical significance in older patients (>60 years), their fecal CK19 was measured by quantitative reverse transcription-polymerase chain reaction. Differences in CK19 transcripts were compared using the nonparametric Mann-Whitney U test. Clinical significance was assessed with the chi-squared test and a binary logistic regression model. The association between overall survival and expressions of fecal CK19 in combination with other serum markers, carcinoembryonic antigen and carbohydrate antigen 19-9 (CA19-9), was evaluated using the Kaplan-Meier method. In these older groups, CRC patients had significantly higher median fecal CK19 expression (p=0.006) than controls. The highest risk of CRC (odds ratio, 5.8; 95% confidence interval, 2.3-14.7; p

Original languageEnglish
Pages (from-to)703-708
Number of pages6
JournalGenetic Testing and Molecular Biomarkers
Volume14
Issue number5
DOIs
Publication statusPublished - Oct 1 2010

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ASJC Scopus subject areas

  • Genetics(clinical)

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