Upregulation of fecal cytokeratin 19 is associated with prognosis in older colorectal cancer patients

Ruey Neng Yang, Shung Haur Yang, Chun Chao Chang, Chih Cheng Chien, Shiann Pan, Chi Jung Huang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The upregulation of fecal cytokeratin 19 (CK19) correlates with age and metastatic status in human colorectal cancer (CRC). To further explore its clinical significance in older patients (>60 years), their fecal CK19 was measured by quantitative reverse transcription-polymerase chain reaction. Differences in CK19 transcripts were compared using the nonparametric Mann-Whitney U test. Clinical significance was assessed with the chi-squared test and a binary logistic regression model. The association between overall survival and expressions of fecal CK19 in combination with other serum markers, carcinoembryonic antigen and carbohydrate antigen 19-9 (CA19-9), was evaluated using the Kaplan-Meier method. In these older groups, CRC patients had significantly higher median fecal CK19 expression (p=0.006) than controls. The highest risk of CRC (odds ratio, 5.8; 95% confidence interval, 2.3-14.7; p

Original languageEnglish
Pages (from-to)703-708
Number of pages6
JournalGenetic Testing and Molecular Biomarkers
Volume14
Issue number5
DOIs
Publication statusPublished - Oct 1 2010

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Keratin-19
Colorectal Neoplasms
Up-Regulation
Logistic Models
Carcinoembryonic Antigen
Differentiation Antigens
Nonparametric Statistics
Reverse Transcription
Biomarkers
Odds Ratio
Carbohydrates
Confidence Intervals
Antigens
Polymerase Chain Reaction
Survival

ASJC Scopus subject areas

  • Genetics(clinical)

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Upregulation of fecal cytokeratin 19 is associated with prognosis in older colorectal cancer patients. / Yang, Ruey Neng; Yang, Shung Haur; Chang, Chun Chao; Chien, Chih Cheng; Pan, Shiann; Huang, Chi Jung.

In: Genetic Testing and Molecular Biomarkers, Vol. 14, No. 5, 01.10.2010, p. 703-708.

Research output: Contribution to journalArticle

Yang, Ruey Neng ; Yang, Shung Haur ; Chang, Chun Chao ; Chien, Chih Cheng ; Pan, Shiann ; Huang, Chi Jung. / Upregulation of fecal cytokeratin 19 is associated with prognosis in older colorectal cancer patients. In: Genetic Testing and Molecular Biomarkers. 2010 ; Vol. 14, No. 5. pp. 703-708.
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