Up-regulation of connective tissue growth factor in hyperoxia-induced lung fibrosis

Chung Ming Chen, Leng Fang Wang, Hsiu Chu Chou, Yaw Dong Lang, Yi Ping Lai

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Pulmonary oxygen toxicity plays an important role in the lung injury process that leads to the development of bronchopulmonary dysplasia. Connective tissue growth factor (CTGF) is a fibroblast mitogen and promoter of collagen deposition. We investigated the effects of postnatal hyperoxia on lung collagen and CTGF expression in rats. Rat pups were exposed to 7 d of >95% O2 and a further 3 wk of 60% O2. CTGF mRNA and protein expression increased after hyperoxia treatment, and the values were significantly higher in hyperoxia-exposed rats on postnatal d 7 and 14. Lung collagen levels increased as rats aged, and the values were comparable between room air-exposed and hyperoxia-exposed rats on postnatal d 7 and 14 and were significantly higher in hyperoxia-exposed rats on postnatal d 21 and 28. Increases in CTGF mRNA and protein expressions preceded the onset of increased lung collagen. These data demonstrate that CTGF is up-regulated at time points preceding the fibrotic phase of the lung injury adding credence to the hypothesis that CTGF seems to be involved in the pathogenesis of hyperoxia-induced lung fibrosis and an anti-CTGF strategy might attenuate hyperoxia-induced lung fibrosis.

Original languageEnglish
Pages (from-to)128-133
Number of pages6
JournalPediatric Research
Volume62
Issue number2
DOIs
Publication statusPublished - Aug 2007

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Connective Tissue Growth Factor
Hyperoxia
Fibrosis
Up-Regulation
Lung
Collagen
Lung Injury
Bronchopulmonary Dysplasia
Messenger RNA
Mitogens
Proteins
Fibroblasts
Air
Oxygen

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Up-regulation of connective tissue growth factor in hyperoxia-induced lung fibrosis. / Chen, Chung Ming; Wang, Leng Fang; Chou, Hsiu Chu; Lang, Yaw Dong; Lai, Yi Ping.

In: Pediatric Research, Vol. 62, No. 2, 08.2007, p. 128-133.

Research output: Contribution to journalArticle

Chen, Chung Ming ; Wang, Leng Fang ; Chou, Hsiu Chu ; Lang, Yaw Dong ; Lai, Yi Ping. / Up-regulation of connective tissue growth factor in hyperoxia-induced lung fibrosis. In: Pediatric Research. 2007 ; Vol. 62, No. 2. pp. 128-133.
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