Unusual clonal evolution in a case of chronic myelogenous leukemia

J. Whang Peng, S. Broder, E. Lee, R. C. Young

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Several unusual cytogenetic changes have occurred during the evolution of chronic myelogenous leukemia in a 32 year old white male with this disease for 8 years. The first appearance of a hypodiploid cell line containing a dicentric marker occurred 2 years after diagnosis and this line was eliminated by several courses of therapy with hydroxyurea. A second clone, which had a partial deletion of the long arm of one of the number 8 chromosomes (8q-) was noted a year later, but this line is refractory to intensive combination chemotherapy.

Original languageEnglish
Pages (from-to)345-354
Number of pages10
JournalActa Haematologica
Volume56
Issue number6
Publication statusPublished - Dec 1 1976
Externally publishedYes

Fingerprint

Clonal Evolution
Chromosomes, Human, Pair 8
Hydroxyurea
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Combination Drug Therapy
Cytogenetics
Clone Cells
Cell Line
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)
  • Hematology

Cite this

Whang Peng, J., Broder, S., Lee, E., & Young, R. C. (1976). Unusual clonal evolution in a case of chronic myelogenous leukemia. Acta Haematologica, 56(6), 345-354.

Unusual clonal evolution in a case of chronic myelogenous leukemia. / Whang Peng, J.; Broder, S.; Lee, E.; Young, R. C.

In: Acta Haematologica, Vol. 56, No. 6, 01.12.1976, p. 345-354.

Research output: Contribution to journalArticle

Whang Peng, J, Broder, S, Lee, E & Young, RC 1976, 'Unusual clonal evolution in a case of chronic myelogenous leukemia', Acta Haematologica, vol. 56, no. 6, pp. 345-354.
Whang Peng, J. ; Broder, S. ; Lee, E. ; Young, R. C. / Unusual clonal evolution in a case of chronic myelogenous leukemia. In: Acta Haematologica. 1976 ; Vol. 56, No. 6. pp. 345-354.
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