Abstract
Several unusual cytogenetic changes have occurred during the evolution of chronic myelogenous leukemia in a 32 year old white male with this disease for 8 years. The first appearance of a hypodiploid cell line containing a dicentric marker occurred 2 years after diagnosis and this line was eliminated by several courses of therapy with hydroxyurea. A second clone, which had a partial deletion of the long arm of one of the number 8 chromosomes (8q-) was noted a year later, but this line is refractory to intensive combination chemotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 345-354 |
| Number of pages | 10 |
| Journal | Acta Haematologica |
| Volume | 56 |
| Issue number | 6 |
| Publication status | Published - Dec 1 1976 |
| Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)
- Hematology