Unreliability of pulse contour-derived cardiac output in piglets simulating acute hemorrhagic shock and rapid volume expansion

Chih Hsin Lee, Jann Yuan Wang, Kuo Liang Huang, Hung Wen Chiu, Tsung Ching Fei, Tsui Shia Chen, Hung Chang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Pulse contour-derived cardiac output for continuous hemodynamic monitoring is becoming popular in critical care. However, the data regarding its reliability during acute hemodynamic instability are inconsistent. This study was conducted to determine whether pulse contour-derived cardiac output truly reflects rapid hemodynamic changes. Methods: Hemorrhagic shock was created in seven anesthetized piglets by continuous blood withdrawal at a rate of 1 mL • kg • min for 20 minutes. Volume expansion with 10% hydroxyethyl starch 8 mL • kg was then administered for 5 minutes. Pulse contour-derived and thermodilution- derived hemodynamic parameters were compared. Results: Baseline thermodilution-derived cardiac index was 3.2 ± 0.4 L • min • M. After exsanguination, it decreased to 2.1 ± 0.3 L • min • M while pulse contour-derived cardiac index increased to 4.4 ± 0.4 L • min • M (p value

Original languageEnglish
Pages (from-to)1357-1361
Number of pages5
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume68
Issue number6
DOIs
Publication statusPublished - Jun 2010
Externally publishedYes

Keywords

  • Arterial pressure
  • Cardiac output
  • Hemodynamic monitoring
  • Model
  • Pig
  • Thermodilution

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

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