Unleashing potential: Transcranial direct current stimulation over the right posterior parietal cortex improves change detection in low-performing individuals

Philip Tseng, Tzu Yu Hsu, Chi Fu Chang, Ovid J L Tzeng, Daisy L. Hung, Neil G. Muggleton, Vincent Walsh, Wei Kuang Liang, Shih Kuen Cheng, Chi Hung Juan

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

The limits of human visual short-term memory (VSTM) have been well documented, and recent neuroscientific studies suggest that VSTM performance is associated with activity in the posterior parietal cortex. Here we show that artificially elevating parietal activity via positively charged electric current through the skull can rapidly and effortlessly improve people's VSTM performance. This artificial improvement, however, comes withan interesting twist: itinteracts with people's natural VSTM capability such that low performers who tend to remember less information benefitted from the stimulation, whereas high performers did not. This behavioral dichotomy is explained by event-related potentials around the parietal regions: lowper formers showed increasedwaveformsinN2pcandcontralateral delay activity (CDA), which implies improvement in attention deployment and memory access in the current paradigm, respectively. Interestingly, these components are found during the presentation of the test array instead of the retention interval, from the parietal sites ipsilateral to the target location, thus suggesting that transcranial direct current stimulation (tDCS) was mainly improving one's ability to suppress no-change distractors located on the irrelevant side of the display during the comparison stage. The high performers, however, did not benefit from tDCS as they showed equally large waveforms in N2pc and CDA, or SPCN (sustained parietal contralateral negativity), before and after the stimulation such that electrical stimulation could not help any further, which also accurately accounts for our behavioral observations. Together, these results suggest that thereis indeed a fixed upper limit inVSTM, but the low performers can benefit from neurostimulation to reach that maximum via enhanced comparison processes, and such behavioral improvement can be directly quantified and visualized by the magnitude of its associated electrophysiological waveforms.

Original languageEnglish
Pages (from-to)10554-10561
Number of pages8
JournalJournal of Neuroscience
Volume32
Issue number31
DOIs
Publication statusPublished - Aug 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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