Universal screening for biliary atresia using an infant stool color card in Taiwan

Cheng Hui Hsiao, Mei Hwei Chang, Huey Ling Chen, Hung Chang Lee, Tzee Chung Wu, Chieh Chung Lin, Yao Jong Yang, An Chyi Chen, Mao Meng Tiao, Beng Huat Lau, Chia Hsiang Chu, Ming Wei Lai, Shiun Bin Fang, Wan Hsin Wen, Yu Hsien Wang, Ke Sheng Wang, Chien Sheng Shih, Chun Hsien Yu, Kun Mei Lee, I. Hsien LeeLung Huang Lin, Wen Terng Lin, Yu Cheng Lin, Yu Kung Chou, Hsiang Hung Shih, Pi Feng Chang, Cheng Hsing Fan, Yu Chang Hsu, Ching Fing Huang, I. Fei Huang, Miao Ling Huang, Kuo Ting Tang, Chun Yan Yeung, Jiun Nan Yeh, Ming Hua Chen, Hui Wen Chen, Shan Ming Chen, Te Jen Chen, Man Kuang Lai, Ya Huei Tsai, Te Kuei Hsieh

Research output: Contribution to journalArticle

164 Citations (Scopus)

Abstract

Biliary atresia is the most common cause of death from liver disease in children. Although the Kasai operation before 60 days of age can significantly improve prognosis, delay in referral and surgery remains a formidable problem worldwide because of difficulties in differentiating it from benign prolonged neonatal jaundice. We established a universal screening system using an infant stool color card to promote the early diagnosis and treatment of biliary atresia. After a pilot regional study in 2002-2003, a national stool color screening system was established by integrating the infant stool color card into the child health booklet given to every neonate in Taiwan since 2004. Within 24 hours of the discovery of an abnormal stool color, this event is reported to the registry center. The annual incidence of biliary atresia per 10,000 live births in 2004 and 2005 was 1.85 (40/216,419) and 1.70 (35/205,854), respectively. The sensitivity of detecting biliary atresia using stool cards before 60 days of age was 72.5% in 2004, which improved to 97.1% in 2005. The national rate of the Kasai operation before 60 days of age increased from 60% in 2004 to 74.3% in 2005. The jaundice-free rate (

Original languageEnglish
Pages (from-to)1233-1240
Number of pages8
JournalHepatology
Volume47
Issue number4
DOIs
Publication statusPublished - Apr 2008
Externally publishedYes

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Biliary Atresia
Taiwan
Color
Neonatal Jaundice
Pamphlets
Live Birth
Jaundice
Registries
Liver Diseases
Early Diagnosis
Cause of Death
Referral and Consultation
Newborn Infant
Incidence
Therapeutics

ASJC Scopus subject areas

  • Hepatology

Cite this

Hsiao, C. H., Chang, M. H., Chen, H. L., Lee, H. C., Wu, T. C., Lin, C. C., ... Hsieh, T. K. (2008). Universal screening for biliary atresia using an infant stool color card in Taiwan. Hepatology, 47(4), 1233-1240. https://doi.org/10.1002/hep.22182

Universal screening for biliary atresia using an infant stool color card in Taiwan. / Hsiao, Cheng Hui; Chang, Mei Hwei; Chen, Huey Ling; Lee, Hung Chang; Wu, Tzee Chung; Lin, Chieh Chung; Yang, Yao Jong; Chen, An Chyi; Tiao, Mao Meng; Lau, Beng Huat; Chu, Chia Hsiang; Lai, Ming Wei; Fang, Shiun Bin; Wen, Wan Hsin; Wang, Yu Hsien; Wang, Ke Sheng; Shih, Chien Sheng; Yu, Chun Hsien; Lee, Kun Mei; Lee, I. Hsien; Lin, Lung Huang; Lin, Wen Terng; Lin, Yu Cheng; Chou, Yu Kung; Shih, Hsiang Hung; Chang, Pi Feng; Fan, Cheng Hsing; Hsu, Yu Chang; Huang, Ching Fing; Huang, I. Fei; Huang, Miao Ling; Tang, Kuo Ting; Yeung, Chun Yan; Yeh, Jiun Nan; Chen, Ming Hua; Chen, Hui Wen; Chen, Shan Ming; Chen, Te Jen; Lai, Man Kuang; Tsai, Ya Huei; Hsieh, Te Kuei.

In: Hepatology, Vol. 47, No. 4, 04.2008, p. 1233-1240.

Research output: Contribution to journalArticle

Hsiao, CH, Chang, MH, Chen, HL, Lee, HC, Wu, TC, Lin, CC, Yang, YJ, Chen, AC, Tiao, MM, Lau, BH, Chu, CH, Lai, MW, Fang, SB, Wen, WH, Wang, YH, Wang, KS, Shih, CS, Yu, CH, Lee, KM, Lee, IH, Lin, LH, Lin, WT, Lin, YC, Chou, YK, Shih, HH, Chang, PF, Fan, CH, Hsu, YC, Huang, CF, Huang, IF, Huang, ML, Tang, KT, Yeung, CY, Yeh, JN, Chen, MH, Chen, HW, Chen, SM, Chen, TJ, Lai, MK, Tsai, YH & Hsieh, TK 2008, 'Universal screening for biliary atresia using an infant stool color card in Taiwan', Hepatology, vol. 47, no. 4, pp. 1233-1240. https://doi.org/10.1002/hep.22182
Hsiao CH, Chang MH, Chen HL, Lee HC, Wu TC, Lin CC et al. Universal screening for biliary atresia using an infant stool color card in Taiwan. Hepatology. 2008 Apr;47(4):1233-1240. https://doi.org/10.1002/hep.22182
Hsiao, Cheng Hui ; Chang, Mei Hwei ; Chen, Huey Ling ; Lee, Hung Chang ; Wu, Tzee Chung ; Lin, Chieh Chung ; Yang, Yao Jong ; Chen, An Chyi ; Tiao, Mao Meng ; Lau, Beng Huat ; Chu, Chia Hsiang ; Lai, Ming Wei ; Fang, Shiun Bin ; Wen, Wan Hsin ; Wang, Yu Hsien ; Wang, Ke Sheng ; Shih, Chien Sheng ; Yu, Chun Hsien ; Lee, Kun Mei ; Lee, I. Hsien ; Lin, Lung Huang ; Lin, Wen Terng ; Lin, Yu Cheng ; Chou, Yu Kung ; Shih, Hsiang Hung ; Chang, Pi Feng ; Fan, Cheng Hsing ; Hsu, Yu Chang ; Huang, Ching Fing ; Huang, I. Fei ; Huang, Miao Ling ; Tang, Kuo Ting ; Yeung, Chun Yan ; Yeh, Jiun Nan ; Chen, Ming Hua ; Chen, Hui Wen ; Chen, Shan Ming ; Chen, Te Jen ; Lai, Man Kuang ; Tsai, Ya Huei ; Hsieh, Te Kuei. / Universal screening for biliary atresia using an infant stool color card in Taiwan. In: Hepatology. 2008 ; Vol. 47, No. 4. pp. 1233-1240.
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abstract = "Biliary atresia is the most common cause of death from liver disease in children. Although the Kasai operation before 60 days of age can significantly improve prognosis, delay in referral and surgery remains a formidable problem worldwide because of difficulties in differentiating it from benign prolonged neonatal jaundice. We established a universal screening system using an infant stool color card to promote the early diagnosis and treatment of biliary atresia. After a pilot regional study in 2002-2003, a national stool color screening system was established by integrating the infant stool color card into the child health booklet given to every neonate in Taiwan since 2004. Within 24 hours of the discovery of an abnormal stool color, this event is reported to the registry center. The annual incidence of biliary atresia per 10,000 live births in 2004 and 2005 was 1.85 (40/216,419) and 1.70 (35/205,854), respectively. The sensitivity of detecting biliary atresia using stool cards before 60 days of age was 72.5{\%} in 2004, which improved to 97.1{\%} in 2005. The national rate of the Kasai operation before 60 days of age increased from 60{\%} in 2004 to 74.3{\%} in 2005. The jaundice-free rate (",
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AU - Yang, Yao Jong

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AU - Chang, Pi Feng

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AU - Tang, Kuo Ting

AU - Yeung, Chun Yan

AU - Yeh, Jiun Nan

AU - Chen, Ming Hua

AU - Chen, Hui Wen

AU - Chen, Shan Ming

AU - Chen, Te Jen

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AU - Tsai, Ya Huei

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