Ultra-fast and sensitive silicon nanobelt field-effect transistor for high-throughput screening of alpha-fetoprotein

Yankuba B. Manga, Fu Hsiang Ko, Yuh Shyong Yang, Jia Yang Hung, Wen Luh Yang, Haw Ming Huang, Chi Chang Wu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In this paper, we described a novel fabrication technique for Silicon nanobelt field-effect transistors (SiNB FETs) based on the Local Oxidation of Silicon (LOCOS) process widely utilized in the manufacturing of microelectronics components and explore it to screened alpha-fetoprotein (AFP). LOCOS process is used as it enables thorough compatibility with complementary metal oxide semiconductor (CMOS) technology. Thus, the need for expensive lithography tools to define the nanoscale pattern is avoided. The SiNB FETs emerges as a powerful biosensor for ultrasensitive, label-free for biological/chemical detection and direct electrical readout. The analytical sensing results of the fabricated SiNB FETs employed as a biomolecular sensor for the early, real-time, and label-free screening of AFP can be understood in term of the change in charge density at the silicon nanobelt surface after functionalization. It is observed that, by tuning the gate voltage, the electrical linearity response of the system towards AFP extends its concentration range from 3. ng/mL to 100. ng/mL, allowing the screening of hepatocellular carcinoma (HCC). These results indicate that the detection of AFP under our direct, label-free, and ultrasensitive biosensor in a microfluidic channel could be one of the promising state-of-the-art techniques applicable as an AFP detector in real samples.

Original languageEnglish
Pages (from-to)1114-1121
JournalSensors and Actuators, B: Chemical
Volume256
DOIs
Publication statusPublished - Mar 2018

Fingerprint

silicon transistors
Nanobelts
alpha-Fetoproteins
Silicon
Field effect transistors
Screening
screening
field effect transistors
Throughput
bioinstrumentation
silicon
chemical detection
Labels
oxidation
Biosensors
microelectronics
compatibility
linearity
readout
CMOS

Keywords

  • Alpha-fetoprotein
  • Biomolecular
  • Hepatocellular carcinoma
  • Locos
  • Nanobelt
  • Ultrasensitive

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

Cite this

Ultra-fast and sensitive silicon nanobelt field-effect transistor for high-throughput screening of alpha-fetoprotein. / Manga, Yankuba B.; Ko, Fu Hsiang; Yang, Yuh Shyong; Hung, Jia Yang; Yang, Wen Luh; Huang, Haw Ming; Wu, Chi Chang.

In: Sensors and Actuators, B: Chemical, Vol. 256, 03.2018, p. 1114-1121.

Research output: Contribution to journalArticle

Manga, Yankuba B. ; Ko, Fu Hsiang ; Yang, Yuh Shyong ; Hung, Jia Yang ; Yang, Wen Luh ; Huang, Haw Ming ; Wu, Chi Chang. / Ultra-fast and sensitive silicon nanobelt field-effect transistor for high-throughput screening of alpha-fetoprotein. In: Sensors and Actuators, B: Chemical. 2018 ; Vol. 256. pp. 1114-1121.
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