Ulcerative colitis and pregnancy outcomes in an Asian population

Herng Ching Lin, Ching Che Jason Chiu, Shu Fen Chen, Horng Yuan Lou, Wen Ta Chiu, Yi Hua Chen

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objectives: As the prevalence of ulcerative colitis (UC) is much higher in Western countries than in Asian countries, previous investigations of pregnancy outcomes for women with UC were limited to people of European descent. This study was aimed at examining the risk of adverse pregnancy outcomes (low birth weight (LBW), preterm birth, small for gestational age (SGA), and cesarean section (CS)) among Asian women with UC. Methods: Using a 3-year nationwide population-based database, we identified a total of 196 women who gave birth from 2001 to 2003, who were diagnosed with UC within 2 years before their index deliveries. A total of 1,568 unaffected pregnant women matched these cases according to age and year of delivery. Conditional logistic regression analyses were performed to estimate risk. Results: There were significant differences between women with and without UC in terms of LBW (12.76% vs. 5.55, P0.001) and preterm births (11.73% vs. 6.25%, P0.004). After adjusting for infant gender, parity, maternal age, highest maternal educational level, parental age difference, maternal marital status, hypertension, diabetes, anemia, family monthly income, as well as conditioning on maternal age and year of delivery, the odds of LBW and preterm births for women with UC were 2.36 (95% confidence interval (CI)1.45-3.82) and 1.90 (95% CI1.16-3.11) times, respectively, those for unaffected women. Conclusions: Although UC often follows a milder disease course in Asians than in people of European descent, we demonstrated that Asian women suffering from UC were still at risk of having preterm and LBW babies, compared with unaffected mothers.

Original languageEnglish
Pages (from-to)387-394
Number of pages8
JournalAmerican Journal of Gastroenterology
Volume105
Issue number2
DOIs
Publication statusPublished - Feb 2010

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Pregnancy Outcome
Ulcerative Colitis
Premature Birth
Low Birth Weight Infant
Population
Maternal Age
Mothers
Term Birth
Marital Status
Parity
Cesarean Section
Gestational Age
Anemia
Pregnant Women
Parents
Logistic Models
Regression Analysis
Parturition
Databases
Confidence Intervals

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Ulcerative colitis and pregnancy outcomes in an Asian population. / Lin, Herng Ching; Chiu, Ching Che Jason; Chen, Shu Fen; Lou, Horng Yuan; Chiu, Wen Ta; Chen, Yi Hua.

In: American Journal of Gastroenterology, Vol. 105, No. 2, 02.2010, p. 387-394.

Research output: Contribution to journalArticle

Lin, Herng Ching ; Chiu, Ching Che Jason ; Chen, Shu Fen ; Lou, Horng Yuan ; Chiu, Wen Ta ; Chen, Yi Hua. / Ulcerative colitis and pregnancy outcomes in an Asian population. In: American Journal of Gastroenterology. 2010 ; Vol. 105, No. 2. pp. 387-394.
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