UGT1A1 polymorphisms associated with risk of induced liver disorders by anti-tuberculosis medications

J. C. Chang, E. H. Liu, C. N. Lee, Y. C. Lin, M. C. Yu, K. J. Bai, Hsiang Yin Chen

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

First-line drug treatment for tuberculosis (TB) is frequently associated with liver toxicity. The goal of this study was to examine the association between UDP-glucuronosyl- transferase 1A1 (UGT1A1) genetic variations and anti-tuberculosis drug-induced hepatotoxicity (ATDH). A total of 98 patients, including 17 patients with ATDH, were enrolled; compound UGT1A1*27 and UGT1A1*28 were associated with an increased risk for developing ATDH after adjusting for age (OR 13.859; 95%CI 1.085-177.056). These findings require confirmation. However, screening for genetic variations prior to TB treatment may reduce the incidence of ATDH and improve treatment adherence.

Original languageEnglish
Pages (from-to)376-378
Number of pages3
JournalInternational Journal of Tuberculosis and Lung Disease
Volume16
Issue number3
DOIs
Publication statusPublished - Mar 1 2012

Keywords

  • Anti-tuberculosis drug-induced hepatotoxicity
  • ATDH
  • NAT2
  • UGT1A1

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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