Tyrosine kinases and gastric cancer

Wen Chang Lin, Hsiao Wei Kao, Daniel Robinson, Hsing Jien Kung, Chew Wun Wu, Hua Chien Chen

Research output: Contribution to journalReview article

53 Citations (Scopus)

Abstract

Carcinoma of the stomach is one of the most prevalent cancer types in the world today. Two major forms of gastric cancer are distinguished according to their morphological and clinicopathological classifications (well differentiated/intestinal type and poorly differentiated/diffuse type), characteristics that could also be attributed to the altered expression of different types of oncogenes or tumor suppressor genes. Significant differences exist for gastric cancer incidence comparing people of different ethnic origins, implicating various genetic and epigenetic factors for gastric oncogenesis. There are only a limited number of molecular markers available for gastric cancer detection and prognostic evaluation, among which are tyrosine kinases. There is convincing evidence that tyrosine kinases are involved in oncogenesis and disease progression for many human cancers. Amplifications of certain tyrosine kinases (c-met, k-sam and erbB2/neu) have been associated with human gastric cancer progression. Alternatively spliced transcripts and enhanced protein-expression levels for some of these tyrosine kinases are correlated with clinical outcomes for gastric cancer patients. With advent of high throughput techniques, it is now possible to detect nearly all expressed tyrosine kinases in a single screen. This increases the chance to identify additional tyrosine kinases as predictive markers for gastric cancers. In this article, we will first review the literature data concerning certain tyrosine kinases implicated in gastric carcinogenesis and then summarize more recent work which provide comprehensive tyrosine kinase profiles for gastric cancer specimens and cell lines. Two new gastric cancer molecular markers (tie-1 and mkk4) have been identified through the use of these profiles and demonstrated effective as clinical prognostic indicators.

Original languageEnglish
Pages (from-to)5680-5689
Number of pages10
JournalOncogene
Volume19
Issue number49
Publication statusPublished - Nov 20 2000
Externally publishedYes

Fingerprint

Protein-Tyrosine Kinases
Stomach Neoplasms
Stomach
Carcinogenesis
Tumor Suppressor Genes
Oncogenes
Epigenomics
Disease Progression
Neoplasms
Carcinoma
Cell Line
Incidence
Proteins

Keywords

  • Gastric cancer
  • Protein-tyrosine kinase profile

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Lin, W. C., Kao, H. W., Robinson, D., Kung, H. J., Wu, C. W., & Chen, H. C. (2000). Tyrosine kinases and gastric cancer. Oncogene, 19(49), 5680-5689.

Tyrosine kinases and gastric cancer. / Lin, Wen Chang; Kao, Hsiao Wei; Robinson, Daniel; Kung, Hsing Jien; Wu, Chew Wun; Chen, Hua Chien.

In: Oncogene, Vol. 19, No. 49, 20.11.2000, p. 5680-5689.

Research output: Contribution to journalReview article

Lin, WC, Kao, HW, Robinson, D, Kung, HJ, Wu, CW & Chen, HC 2000, 'Tyrosine kinases and gastric cancer', Oncogene, vol. 19, no. 49, pp. 5680-5689.
Lin WC, Kao HW, Robinson D, Kung HJ, Wu CW, Chen HC. Tyrosine kinases and gastric cancer. Oncogene. 2000 Nov 20;19(49):5680-5689.
Lin, Wen Chang ; Kao, Hsiao Wei ; Robinson, Daniel ; Kung, Hsing Jien ; Wu, Chew Wun ; Chen, Hua Chien. / Tyrosine kinases and gastric cancer. In: Oncogene. 2000 ; Vol. 19, No. 49. pp. 5680-5689.
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