Two photon polymerization-micromolding of polyethylene glycol-gentamicin sulfate microneedles

Shaun D. Gittard, Aleksandr Ovsianikov, Hasan Akar, Boris Chichkov, Nancy A. Monteiro-Riviere, Shane Stafslien, Bret Chisholm, Chun Che Shin, Chun Ming Shih, Shing Jong Lin, Yea Yang Su, Roger J. Narayan

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The use of microneedles for transdermal drug delivery is limited due to the risk of infection associated with formation of channels through the stratum corneum layer of the epidermis. The risk of infection associated with use of microneedles may be reduced by imparting these devices with antimicrobial properties. In this study, a photopolymerization-micromolding technique was used to fabricate microneedle arrays from a photosensitive material containing polyethylene glycol 600 diacrylate, gentamicin sulfate, and a photoinitiator. Scanning electron microscopy indicated that the photopolymerization-micromolding process produced microneedle arrays that exhibited good microneedle-to- microneedle uniformity. An agar plating assay revealed that microneedles fabricated with polyethylene glycol 600 diacrylate containing 2mg mL -1 gentamicin sulfate inhibited growth of Staphylococcus aureus bacteria. Scanning electron microscopy revealed no platelet aggregation on the surfaces of platelet rich plasma-exposed undoped polyethylene glycol 600 diacrylate microneedles and gentamicin-doped polyethylene glycol 600 diacrylate microneedles. These efforts will enable wider adoption of microneedles for transdermal delivery of pharmacologic agents.

Original languageEnglish
JournalAdvanced Engineering Materials
Volume12
Issue number4
DOIs
Publication statusPublished - Apr 2010

Fingerprint

Gentamicins
Polyethylene glycols
glycols
polyethylenes
sulfates
Photons
polymerization
Polymerization
Photopolymerization
photons
infectious diseases
Platelets
platelets
delivery
epidermis
Scanning electron microscopy
scanning electron microscopy
cornea
staphylococcus
strata

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Gittard, S. D., Ovsianikov, A., Akar, H., Chichkov, B., Monteiro-Riviere, N. A., Stafslien, S., ... Narayan, R. J. (2010). Two photon polymerization-micromolding of polyethylene glycol-gentamicin sulfate microneedles. Advanced Engineering Materials, 12(4). https://doi.org/10.1002/adem.200980012

Two photon polymerization-micromolding of polyethylene glycol-gentamicin sulfate microneedles. / Gittard, Shaun D.; Ovsianikov, Aleksandr; Akar, Hasan; Chichkov, Boris; Monteiro-Riviere, Nancy A.; Stafslien, Shane; Chisholm, Bret; Shin, Chun Che; Shih, Chun Ming; Lin, Shing Jong; Su, Yea Yang; Narayan, Roger J.

In: Advanced Engineering Materials, Vol. 12, No. 4, 04.2010.

Research output: Contribution to journalArticle

Gittard, SD, Ovsianikov, A, Akar, H, Chichkov, B, Monteiro-Riviere, NA, Stafslien, S, Chisholm, B, Shin, CC, Shih, CM, Lin, SJ, Su, YY & Narayan, RJ 2010, 'Two photon polymerization-micromolding of polyethylene glycol-gentamicin sulfate microneedles', Advanced Engineering Materials, vol. 12, no. 4. https://doi.org/10.1002/adem.200980012
Gittard, Shaun D. ; Ovsianikov, Aleksandr ; Akar, Hasan ; Chichkov, Boris ; Monteiro-Riviere, Nancy A. ; Stafslien, Shane ; Chisholm, Bret ; Shin, Chun Che ; Shih, Chun Ming ; Lin, Shing Jong ; Su, Yea Yang ; Narayan, Roger J. / Two photon polymerization-micromolding of polyethylene glycol-gentamicin sulfate microneedles. In: Advanced Engineering Materials. 2010 ; Vol. 12, No. 4.
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