Two photon polymerization-micromolding of polyethylene glycol-gentamicin sulfate microneedles

Shaun D. Gittard, Aleksandr Ovsianikov, Hasan Akar, Boris Chichkov, Nancy A. Monteiro-Riviere, Shane Stafslien, Bret Chisholm, Chun Che Shin, Chun Ming Shih, Shing Jong Lin, Yea Yang Su, Roger J. Narayan

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39 Citations (Scopus)

Abstract

The use of microneedles for transdermal drug delivery is limited due to the risk of infection associated with formation of channels through the stratum corneum layer of the epidermis. The risk of infection associated with use of microneedles may be reduced by imparting these devices with antimicrobial properties. In this study, a photopolymerization-micromolding technique was used to fabricate microneedle arrays from a photosensitive material containing polyethylene glycol 600 diacrylate, gentamicin sulfate, and a photoinitiator. Scanning electron microscopy indicated that the photopolymerization-micromolding process produced microneedle arrays that exhibited good microneedle-to- microneedle uniformity. An agar plating assay revealed that microneedles fabricated with polyethylene glycol 600 diacrylate containing 2mg mL -1 gentamicin sulfate inhibited growth of Staphylococcus aureus bacteria. Scanning electron microscopy revealed no platelet aggregation on the surfaces of platelet rich plasma-exposed undoped polyethylene glycol 600 diacrylate microneedles and gentamicin-doped polyethylene glycol 600 diacrylate microneedles. These efforts will enable wider adoption of microneedles for transdermal delivery of pharmacologic agents.

Original languageEnglish
JournalAdvanced Engineering Materials
Volume12
Issue number4
DOIs
Publication statusPublished - Apr 2010

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ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Gittard, S. D., Ovsianikov, A., Akar, H., Chichkov, B., Monteiro-Riviere, N. A., Stafslien, S., Chisholm, B., Shin, C. C., Shih, C. M., Lin, S. J., Su, Y. Y., & Narayan, R. J. (2010). Two photon polymerization-micromolding of polyethylene glycol-gentamicin sulfate microneedles. Advanced Engineering Materials, 12(4). https://doi.org/10.1002/adem.200980012