TW01001, a novel piperazinedione compound, induces mitotic arrest and autophagy in non-small cell lung cancer A549 cells

Mei Chuan Chen, Chun Han Chen, Yi Nan Liu, Hui Po Wang, Shiow Lin Pan, Che Ming Teng

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Here, we report that TW01001, a novel piperazinedione compound, could be a new mitotic inhibitor for the treatment of non-small cell lung cancer by the following observations in A549 cells: (1) induction of cells to accumulate at G2/M phase, which ultimately led to cell apoptotic death, (2) accumulation of p53 and inhibition of survival signalings, and (3) induction of p53-independent autophagy. Taken together, our data suggested that TW01001 induces autophagy-p53-signaling pathway to cause mitotic arrest and cell growth inhibition in A549 cells and provides the framework for further development as a novel therapeutic agent for lung cancer treatment.

Original languageEnglish
Pages (from-to)370-378
Number of pages9
JournalCancer Letters
Volume336
Issue number2
DOIs
Publication statusPublished - Aug 19 2013

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Keywords

  • Apoptosis
  • Autophagy
  • Lung cancer
  • Mitotic arrest
  • Signal transduction

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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