Tumor size matters differently in pulmonary adenocarcinoma and squamous cell carcinoma

Pei Ying Lin, Yeun Chung Chang, Hsuan Yu Chen, Chen Hao Chen, Hung Chang Tsui, Pan Chyr Yang

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Little about primary tumor size and nodal/distant metastases among different cell types in non-small cell lung cancer (NSCLC) was discussed. This study aimed to investigate distinct associations between tumor size and nodal/distant metastases in pulmonary adenocarcinoma and squamous cell carcinoma. The study also aimed to clarify the cutoff size relating to a higher likelihood of metastases. We retrospectively evaluated 932 NSCLC patients over a 3-year period and focused on cases with primary tumors less than 4.0 cm in size. Our data showed that 2.5 cm was the critical cutoff size regarding increased nodal/distant metastases in adenocarcinoma (p < 0.001), but not in squamous cell carcinoma (p > 0.05). In addition, the incidence of nodal/distant metastases reached a plateau of more than 80% in adenocarcinoma when the tumor size exceeded 2.5 cm. In contrast, there was no such correlation observed in squamous cell carcinoma. This study showed that tumor size mattered differently in pulmonary adenocarcinoma and squamous cell carcinoma.

Original languageEnglish
Pages (from-to)296-300
Number of pages5
JournalLung Cancer
Volume67
Issue number3
DOIs
Publication statusPublished - Mar 2010
Externally publishedYes

Keywords

  • Adenocarcinoma
  • Nodal/distant metastases
  • Non-small cell lung cancer (NSCLC)
  • Size
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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