Tumor-infiltrating lymphocytes contain a higher proportion of FOXP3+ T lymphocytes in cervical cancer

Ming Yih Wu, Tzu Yun Kuo, Hong Nerng Ho

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background/Purpose: The subpopulations and functions of tumor-infiltrating lymphocytes (TILs) from cervical cancer (CC) are altered. Dysfunction of TIL could be partially because of the inhibition by regulatory T (T reg) cells. FOXP3 is the control gene for the T reg cells. Methods: We investigated the distribution of TILs and FOXP3 + cells in CC (n = 10) and cervical intraepithelial neoplasia (n = 8) tissues. Double-immunofluorescence and confocal-based image quantitative microscopic analysis were used to calculate the number of cluster of differentiation (CD)4 +CD25 +FOXP3 + T reg cells around the tumor cells. Results: The CD4 +CD25 +FOXP3 + phenotype of T reg cells was accumulated around the tumor cells. CC contains a significantly higher proportion of the FOXP3 + T cells than in cervical intraepithelial neoplasia (p < 0.001). Moreover, CC with lymph node metastasis has a higher proportion of the FOXP3 + T cells than that without lymph node metastasis (p < 0.05). Conclusion: The increased accumulation of T reg cells suggests that T reg cells are important in the immunopathogenesis of CC.

Original languageEnglish
Pages (from-to)580-586
Number of pages7
JournalJournal of the Formosan Medical Association
Volume110
Issue number9
DOIs
Publication statusPublished - Sep 1 2011
Externally publishedYes

Keywords

  • Cervical cancer
  • Cervical intraepithelial neoplasm
  • FOXP3
  • Treg cells

ASJC Scopus subject areas

  • Medicine(all)

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