Tuberculosis outcomes in Taipei

Factors associated with treatment interruption for 2 months and death

Chen Yuan Chiang, J. J. Lee, M. C. Yu, D. A. Enarson, T. P. Lin, K. T. Luh

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

SETTING: All individuals reported as being treated for pulmonary tuberculosis (PTB) among citizens of Taipei City, Taiwan, in 2003. OBJECTIVES: To investigate risk factors associated with treatment interruption for at least 2 consecutive months and death. DESIGN: The outcome of PTB cases was determined by consulting medical charts. RESULTS: Of 1127 PTB patients registered, 824 (73.1%) were successfully treated, 189 (16.8%) died, 65 (5.8%) interrupted treatment, 17 (1.5%) were still on treatment 15 months after commencing treatment and 32 (2.8%) failed. The only significant factor associated with treatment interruption was visits to other health facilities after commencing tuberculosis (TB) treatment. TB patients had a standardised mortality ratio of 8.7 (95%CI 7.5-10.0). Factors significantly associated with death were age (adjusted hazard ratio [adjHR] 1.06. 95%CI 1.05-1.08), sputum culture not performed/unknown (adjHR 2.07, 95%CI 1.47-2.92), and comorbidity with respiratory disease (adjHR 1.68,95%CI 1.24-2.27), infectious disease (adjHR 2.80, 95%CI 2.07-3.78), renal disease (adjHR 2.58,95%CI 1.82-3.66) or cancer (adjHR 3.31, 95%CI 2.35-4.65), compared with other patients. CONCLUSION: Visits to other health facilities were associated with interruption of treatment for at least 2 months. A high proportion of deaths was due to old age and comorbidity.

Original languageEnglish
Pages (from-to)105-111
Number of pages7
JournalInternational Journal of Tuberculosis and Lung Disease
Volume13
Issue number1
Publication statusPublished - Jan 2009
Externally publishedYes

Fingerprint

Tuberculosis
Pulmonary Tuberculosis
Health Facilities
Therapeutics
Comorbidity
Sputum
Taiwan
Communicable Diseases
Kidney
Mortality
Neoplasms

Keywords

  • Death
  • Default
  • Outcome
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Tuberculosis outcomes in Taipei : Factors associated with treatment interruption for 2 months and death. / Chiang, Chen Yuan; Lee, J. J.; Yu, M. C.; Enarson, D. A.; Lin, T. P.; Luh, K. T.

In: International Journal of Tuberculosis and Lung Disease, Vol. 13, No. 1, 01.2009, p. 105-111.

Research output: Contribution to journalArticle

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abstract = "SETTING: All individuals reported as being treated for pulmonary tuberculosis (PTB) among citizens of Taipei City, Taiwan, in 2003. OBJECTIVES: To investigate risk factors associated with treatment interruption for at least 2 consecutive months and death. DESIGN: The outcome of PTB cases was determined by consulting medical charts. RESULTS: Of 1127 PTB patients registered, 824 (73.1{\%}) were successfully treated, 189 (16.8{\%}) died, 65 (5.8{\%}) interrupted treatment, 17 (1.5{\%}) were still on treatment 15 months after commencing treatment and 32 (2.8{\%}) failed. The only significant factor associated with treatment interruption was visits to other health facilities after commencing tuberculosis (TB) treatment. TB patients had a standardised mortality ratio of 8.7 (95{\%}CI 7.5-10.0). Factors significantly associated with death were age (adjusted hazard ratio [adjHR] 1.06. 95{\%}CI 1.05-1.08), sputum culture not performed/unknown (adjHR 2.07, 95{\%}CI 1.47-2.92), and comorbidity with respiratory disease (adjHR 1.68,95{\%}CI 1.24-2.27), infectious disease (adjHR 2.80, 95{\%}CI 2.07-3.78), renal disease (adjHR 2.58,95{\%}CI 1.82-3.66) or cancer (adjHR 3.31, 95{\%}CI 2.35-4.65), compared with other patients. CONCLUSION: Visits to other health facilities were associated with interruption of treatment for at least 2 months. A high proportion of deaths was due to old age and comorbidity.",
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