Triterpene glycosides and phenylpropane derivatives from Staurogyne concinnula possessing anti-angiogenic activity

Thanh Hoa Vo, Yu Chi Lin, Chia Ching Liaw, Wen Pin Pan, Jing Jy Cheng, Ching Kuo Lee, Yao Haur Kuo

Research output: Contribution to journalArticlepeer-review

Abstract

After anti-angiogenic activity screening, the potential n-butanol layer partitioned from the ethanol extract of Staurogyne concinnula was conducted. Further purification by Diaion HP20 column and preparative HPLC chromatography, four undescribed triterpenoid saponin derivatives, along with the known baptisiasaponin I, and four known phenylpropanoid glycosides were isolated and characterized from n-butanol layer. The structures of isolated compounds were elucidated by ESI-MS, 1D, and 2D MNR data. Biological evaluation revealed that baptisiasaponin I possessed significant anti-angiogenic effects (IC50 4.0 ± 0.2 μM). Further mechanism of action of baptisiasaponin I by inhibition of integrin/FAK/paxillin signaling pathway and its downstream effectors as MMP2 and MMP9 are also presented.

Original languageEnglish
Article number112666
JournalPhytochemistry
Volume184
DOIs
Publication statusPublished - Apr 2021

Keywords

  • Acanthaceae
  • Anti-angiogenic effect
  • MMP2
  • MMP9
  • Oleanane saponins
  • Staurogyne concinnula

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

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