Triterpene acids from the leaves of Planchonella duclitan (Blanco) Bakhuizan

Zong-Huei Li; Shin Hun Juang; Feng Lin Hsu; Cheng Yi Wu

doi:10.1002/jccs.200500184

Triterpene acids from the leaves of Planchonella duclitan (Blanco) Bakhuizan

Zong-Huei Li, Shin Hun Juang, Feng Lin Hsu, Cheng Yi Wu

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

From the methanolic extract of the leaves of Planchonella duclitan, 2α,3α,19α,23-tetrahydroxy-13,27-cyclours-11-en-28-oic acid(1), myrianthic acid (2), 2-hydroxyursolic acid (3), ursolic acid (4), pomolic acid (5), rotundic acid (6), and jacoumaric acid (7) were isolated, and their structures were elucidated on the basis of their spectroscopic analysis. Among them, compound 1 was a new cyclopropyl ursane-type triterpene acid. Additionally, compounds 4 and 7 showed significant cytotoxicity toward human colorectal carcinoma cell line HT29 and human breast carcinoma cell line MCF-7 with IC₅₀ values ranging from 5.8 ± 1.4 to 6.5 ± 1.9 μM.

Original language	English
Pages (from-to)	1275-1280
Number of pages	6
Journal	Journal of the Chinese Chemical Society
Volume	52
Issue number	6
DOIs	https://doi.org/10.1002/jccs.200500184
Publication status	Published - 2005

Keywords

2α,3α,19α,23-tetrahydroxy-13,27-cyclours-11-en-28-oic acid
HT29
Leaves
MCF-7
Planchonella duclitan
Sapotaceae
Triterpene acids

ASJC Scopus subject areas

Chemistry(all)

Access to Document

10.1002/jccs.200500184

Cite this

@article{b73992b15c68427798806abfd4295327,

title = "Triterpene acids from the leaves of Planchonella duclitan (Blanco) Bakhuizan",

abstract = "From the methanolic extract of the leaves of Planchonella duclitan, 2α,3α,19α,23-tetrahydroxy-13,27-cyclours-11-en-28-oic acid(1), myrianthic acid (2), 2-hydroxyursolic acid (3), ursolic acid (4), pomolic acid (5), rotundic acid (6), and jacoumaric acid (7) were isolated, and their structures were elucidated on the basis of their spectroscopic analysis. Among them, compound 1 was a new cyclopropyl ursane-type triterpene acid. Additionally, compounds 4 and 7 showed significant cytotoxicity toward human colorectal carcinoma cell line HT29 and human breast carcinoma cell line MCF-7 with IC50 values ranging from 5.8 ± 1.4 to 6.5 ± 1.9 μM.",

keywords = "2α,3α,19α,23-tetrahydroxy-13,27-cyclours-11-en-28-oic acid, HT29, Leaves, MCF-7, Planchonella duclitan, Sapotaceae, Triterpene acids",

author = "Zong-Huei Li and Juang, {Shin Hun} and Hsu, {Feng Lin} and Wu, {Cheng Yi}",

year = "2005",

doi = "10.1002/jccs.200500184",

language = "English",

volume = "52",

pages = "1275--1280",

journal = "Journal of the Chinese Chemical Society",

issn = "0009-4536",

publisher = "Chinese Chemical Society",

number = "6",

}

TY - JOUR

T1 - Triterpene acids from the leaves of Planchonella duclitan (Blanco) Bakhuizan

AU - Li, Zong-Huei

AU - Juang, Shin Hun

AU - Hsu, Feng Lin

AU - Wu, Cheng Yi

PY - 2005

Y1 - 2005

N2 - From the methanolic extract of the leaves of Planchonella duclitan, 2α,3α,19α,23-tetrahydroxy-13,27-cyclours-11-en-28-oic acid(1), myrianthic acid (2), 2-hydroxyursolic acid (3), ursolic acid (4), pomolic acid (5), rotundic acid (6), and jacoumaric acid (7) were isolated, and their structures were elucidated on the basis of their spectroscopic analysis. Among them, compound 1 was a new cyclopropyl ursane-type triterpene acid. Additionally, compounds 4 and 7 showed significant cytotoxicity toward human colorectal carcinoma cell line HT29 and human breast carcinoma cell line MCF-7 with IC50 values ranging from 5.8 ± 1.4 to 6.5 ± 1.9 μM.

AB - From the methanolic extract of the leaves of Planchonella duclitan, 2α,3α,19α,23-tetrahydroxy-13,27-cyclours-11-en-28-oic acid(1), myrianthic acid (2), 2-hydroxyursolic acid (3), ursolic acid (4), pomolic acid (5), rotundic acid (6), and jacoumaric acid (7) were isolated, and their structures were elucidated on the basis of their spectroscopic analysis. Among them, compound 1 was a new cyclopropyl ursane-type triterpene acid. Additionally, compounds 4 and 7 showed significant cytotoxicity toward human colorectal carcinoma cell line HT29 and human breast carcinoma cell line MCF-7 with IC50 values ranging from 5.8 ± 1.4 to 6.5 ± 1.9 μM.

KW - 2α,3α,19α,23-tetrahydroxy-13,27-cyclours-11-en-28-oic acid

KW - HT29

KW - Leaves

KW - MCF-7

KW - Planchonella duclitan

KW - Sapotaceae

KW - Triterpene acids

UR - http://www.scopus.com/inward/record.url?scp=33745857648&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745857648&partnerID=8YFLogxK

U2 - 10.1002/jccs.200500184

DO - 10.1002/jccs.200500184

M3 - Article

AN - SCOPUS:33745857648

SN - 0009-4536

VL - 52

SP - 1275

EP - 1280

JO - Journal of the Chinese Chemical Society

JF - Journal of the Chinese Chemical Society

IS - 6

ER -

Triterpene acids from the leaves of Planchonella duclitan (Blanco) Bakhuizan

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this