Triterpene acids from the leaves of Planchonella duclitan (Blanco) Bakhuizan

Zong-Huei Li, Shin Hun Juang, Feng Lin Hsu, Cheng Yi Wu

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

From the methanolic extract of the leaves of Planchonella duclitan, 2α,3α,19α,23-tetrahydroxy-13,27-cyclours-11-en-28-oic acid(1), myrianthic acid (2), 2-hydroxyursolic acid (3), ursolic acid (4), pomolic acid (5), rotundic acid (6), and jacoumaric acid (7) were isolated, and their structures were elucidated on the basis of their spectroscopic analysis. Among them, compound 1 was a new cyclopropyl ursane-type triterpene acid. Additionally, compounds 4 and 7 showed significant cytotoxicity toward human colorectal carcinoma cell line HT29 and human breast carcinoma cell line MCF-7 with IC50 values ranging from 5.8 ± 1.4 to 6.5 ± 1.9 μM.

Original languageEnglish
Pages (from-to)1275-1280
Number of pages6
JournalJournal of the Chinese Chemical Society
Volume52
Issue number6
Publication statusPublished - 2005

Fingerprint

Triterpenes
Acids
Cells
Spectroscopic analysis
Cytotoxicity

Keywords

  • 2α,3α,19α,23-tetrahydroxy-13,27-cyclours-11-en-28-oic acid
  • HT29
  • Leaves
  • MCF-7
  • Planchonella duclitan
  • Sapotaceae
  • Triterpene acids

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Li, Z-H., Juang, S. H., Hsu, F. L., & Wu, C. Y. (2005). Triterpene acids from the leaves of Planchonella duclitan (Blanco) Bakhuizan. Journal of the Chinese Chemical Society, 52(6), 1275-1280.

Triterpene acids from the leaves of Planchonella duclitan (Blanco) Bakhuizan. / Li, Zong-Huei; Juang, Shin Hun; Hsu, Feng Lin; Wu, Cheng Yi.

In: Journal of the Chinese Chemical Society, Vol. 52, No. 6, 2005, p. 1275-1280.

Research output: Contribution to journalArticle

Li, Z-H, Juang, SH, Hsu, FL & Wu, CY 2005, 'Triterpene acids from the leaves of Planchonella duclitan (Blanco) Bakhuizan', Journal of the Chinese Chemical Society, vol. 52, no. 6, pp. 1275-1280.
Li, Zong-Huei ; Juang, Shin Hun ; Hsu, Feng Lin ; Wu, Cheng Yi. / Triterpene acids from the leaves of Planchonella duclitan (Blanco) Bakhuizan. In: Journal of the Chinese Chemical Society. 2005 ; Vol. 52, No. 6. pp. 1275-1280.
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abstract = "From the methanolic extract of the leaves of Planchonella duclitan, 2α,3α,19α,23-tetrahydroxy-13,27-cyclours-11-en-28-oic acid(1), myrianthic acid (2), 2-hydroxyursolic acid (3), ursolic acid (4), pomolic acid (5), rotundic acid (6), and jacoumaric acid (7) were isolated, and their structures were elucidated on the basis of their spectroscopic analysis. Among them, compound 1 was a new cyclopropyl ursane-type triterpene acid. Additionally, compounds 4 and 7 showed significant cytotoxicity toward human colorectal carcinoma cell line HT29 and human breast carcinoma cell line MCF-7 with IC50 values ranging from 5.8 ± 1.4 to 6.5 ± 1.9 μM.",
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