Triple negative breast carcinoma is a prognostic factor in Taiwanese women

Che Lin, Su Yu Chien, Li Sheng Chen, Shou Jen Kuo, Tsai Wang Chang, Dar Ren Chen

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background: Currently, there is a debate as to whether triple negative breast carcinoma (TNBC) has a worse prognosis than non-TNBC. Our aim was to determine whether TNBC is a prognostic factor for survival. Methods: We identified 1,048 Taiwanese breast carcinoma patients, of whom 167 (15.9%) had TNBC. Data used for analysis were derived from our cancer registry database for women with breast cancer who were diagnosed between 2002 January and 2006 December. Results: In the Kaplan-Meier analysis, tumor subgroup (TNBC vs. non-TNBC) was a prognosis factor related to 5-year overall survival. In the univariate analysis, tumor subgroup (TNBC vs. non-TNBC) was a significant factor related to 5-year overall survival, in addition to age, tumor size, lymph node, metastasis, grade, stage, estrogen receptor status, progesterone receptor status, and HER2 overexpression status. In the multivariate analysis, tumor subgroup was not a significant factor related to 5-year disease-free survival (DFS). In node-positive patients, tumor subgroup was a significant factor related to 5-year overall survival, in addition to age, tumor size, metastasis, and grade. In node-negative patients, tumor subgroup was not a significant factor related to 5-year disease-free survival and 5-year overall survival. Conclusion: Our results indicated that TNBC patients in Taiwan have worse 5-year overall survival than non-TNBC patients. Notably, in node-positive patients, TNBC played a prognostic role in 5-year overall survival.

Original languageEnglish
Article number192
JournalBMC Cancer
Volume9
DOIs
Publication statusPublished - Jun 18 2009
Externally publishedYes

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Breast Neoplasms
Survival
Neoplasms
Disease-Free Survival
Neoplasm Metastasis
Kaplan-Meier Estimate
Progesterone Receptors
Taiwan
Estrogen Receptors
Registries
Multivariate Analysis
Lymph Nodes
Databases

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Genetics

Cite this

Triple negative breast carcinoma is a prognostic factor in Taiwanese women. / Lin, Che; Chien, Su Yu; Chen, Li Sheng; Kuo, Shou Jen; Chang, Tsai Wang; Chen, Dar Ren.

In: BMC Cancer, Vol. 9, 192, 18.06.2009.

Research output: Contribution to journalArticle

Lin, Che ; Chien, Su Yu ; Chen, Li Sheng ; Kuo, Shou Jen ; Chang, Tsai Wang ; Chen, Dar Ren. / Triple negative breast carcinoma is a prognostic factor in Taiwanese women. In: BMC Cancer. 2009 ; Vol. 9.
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abstract = "Background: Currently, there is a debate as to whether triple negative breast carcinoma (TNBC) has a worse prognosis than non-TNBC. Our aim was to determine whether TNBC is a prognostic factor for survival. Methods: We identified 1,048 Taiwanese breast carcinoma patients, of whom 167 (15.9{\%}) had TNBC. Data used for analysis were derived from our cancer registry database for women with breast cancer who were diagnosed between 2002 January and 2006 December. Results: In the Kaplan-Meier analysis, tumor subgroup (TNBC vs. non-TNBC) was a prognosis factor related to 5-year overall survival. In the univariate analysis, tumor subgroup (TNBC vs. non-TNBC) was a significant factor related to 5-year overall survival, in addition to age, tumor size, lymph node, metastasis, grade, stage, estrogen receptor status, progesterone receptor status, and HER2 overexpression status. In the multivariate analysis, tumor subgroup was not a significant factor related to 5-year disease-free survival (DFS). In node-positive patients, tumor subgroup was a significant factor related to 5-year overall survival, in addition to age, tumor size, metastasis, and grade. In node-negative patients, tumor subgroup was not a significant factor related to 5-year disease-free survival and 5-year overall survival. Conclusion: Our results indicated that TNBC patients in Taiwan have worse 5-year overall survival than non-TNBC patients. Notably, in node-positive patients, TNBC played a prognostic role in 5-year overall survival.",
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