Trifunctional Fe3O4/CaP/Alginate Core-Shell-Corona Nanoparticles for Magnetically Guided, pH-Responsive, and Chemically Targeted Chemotherapy

Yu Pu Wang, Yu Te Liao, Chia Hung Liu, Jiashing Yu, Hatem R. Alamri, Zeid A. Alothman, Md Shahriar A. Hossain, Yusuke Yamauchi, Kevin C.W. Wu

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Chemotherapy of bladder cancer has limited efficacy because of the short retention time of drugs in the bladder during therapy. In this research, nanoparticles (NPs) with a new core/shell/corona nanostructure have been synthesized, consisting of iron oxide (Fe3O4) as the core to providing magnetic properties, drug (doxorubicin) loaded calcium phosphate (CaP) as the shell for pH-responsive release, and arginylglycylaspartic acid (RGD)-containing peptide functionalized alginate as the corona for cell targeting (with the composite denoted as RGD-Fe3O4/CaP/Alg NPs). We have optimized the reaction conditions to obtain RGD-Fe3O4/CaP/Alg NPs with high biocompatibility and suitable particle size, surface functionality, and drug loading/release behavior. The results indicate that the RGD-Fe3O4/CaP/Alg NPs exhibit enhanced chemotherapy efficacy toward T24 bladder cancer cells, owing to successful magnetic guidance, pH-responsive release, and improved cellular uptake, which give these NPs great potential as therapeutic agents for future in vivo drug delivery systems.

Original languageEnglish
Pages (from-to)2366-2374
Number of pages9
JournalACS Biomaterials Science and Engineering
Issue number10
Publication statusPublished - Oct 9 2017


  • bladder cancer
  • controlled release
  • core-shell-corona nanoparticles
  • magnetic guidance
  • targeting

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


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