Trifunctional Fe3O4/CaP/Alginate Core-Shell-Corona Nanoparticles for Magnetically Guided, pH-Responsive, and Chemically Targeted Chemotherapy

Yu Pu Wang, Yu Te Liao, Chia Hung Liu, Jiashing Yu, Hatem R. Alamri, Zeid A. Alothman, Md Shahriar A. Hossain, Yusuke Yamauchi, Kevin C.W. Wu

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Chemotherapy of bladder cancer has limited efficacy because of the short retention time of drugs in the bladder during therapy. In this research, nanoparticles (NPs) with a new core/shell/corona nanostructure have been synthesized, consisting of iron oxide (Fe3O4) as the core to providing magnetic properties, drug (doxorubicin) loaded calcium phosphate (CaP) as the shell for pH-responsive release, and arginylglycylaspartic acid (RGD)-containing peptide functionalized alginate as the corona for cell targeting (with the composite denoted as RGD-Fe3O4/CaP/Alg NPs). We have optimized the reaction conditions to obtain RGD-Fe3O4/CaP/Alg NPs with high biocompatibility and suitable particle size, surface functionality, and drug loading/release behavior. The results indicate that the RGD-Fe3O4/CaP/Alg NPs exhibit enhanced chemotherapy efficacy toward T24 bladder cancer cells, owing to successful magnetic guidance, pH-responsive release, and improved cellular uptake, which give these NPs great potential as therapeutic agents for future in vivo drug delivery systems.

Original languageEnglish
Pages (from-to)2366-2374
Number of pages9
JournalACS Biomaterials Science and Engineering
Volume3
Issue number10
DOIs
Publication statusPublished - Oct 9 2017

Fingerprint

Chemotherapy
Alginate
Calcium phosphate
Nanoparticles
Pharmaceutical Preparations
Iron oxides
Biocompatibility
Doxorubicin
Peptides
Nanostructures
Magnetic properties
Particle size
Cells
alginic acid
calcium phosphate
Acids
Composite materials

Keywords

  • bladder cancer
  • controlled release
  • core-shell-corona nanoparticles
  • magnetic guidance
  • targeting

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

Cite this

Trifunctional Fe3O4/CaP/Alginate Core-Shell-Corona Nanoparticles for Magnetically Guided, pH-Responsive, and Chemically Targeted Chemotherapy. / Wang, Yu Pu; Liao, Yu Te; Liu, Chia Hung; Yu, Jiashing; Alamri, Hatem R.; Alothman, Zeid A.; Hossain, Md Shahriar A.; Yamauchi, Yusuke; Wu, Kevin C.W.

In: ACS Biomaterials Science and Engineering, Vol. 3, No. 10, 09.10.2017, p. 2366-2374.

Research output: Contribution to journalArticle

Wang, Yu Pu ; Liao, Yu Te ; Liu, Chia Hung ; Yu, Jiashing ; Alamri, Hatem R. ; Alothman, Zeid A. ; Hossain, Md Shahriar A. ; Yamauchi, Yusuke ; Wu, Kevin C.W. / Trifunctional Fe3O4/CaP/Alginate Core-Shell-Corona Nanoparticles for Magnetically Guided, pH-Responsive, and Chemically Targeted Chemotherapy. In: ACS Biomaterials Science and Engineering. 2017 ; Vol. 3, No. 10. pp. 2366-2374.
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