Tricuspid Flow Propagation Velocity Predicts Exercise Tolerance and Readmission in Patients With Systemic Lupus Erythematosus

Chin Chang Cheng, Wei Chun Huang, Kuan Rau Chiou, Shih Hung Hsiao, Shih Kai Lin, Ling Ying Lu, Jui Cheng Tseng, Jui Chieh Hu, Guang Yuan Mar, Chuen Wang Chiou, Shoa lin Lin, Chun Peng Liu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Evaluating right ventricular dysfunction, pulmonary artery systolic pressure (PASP), and exercise tolerance is critical in patients with systemic lupus erythematosus (SLE) because of the high mortality rate in such patients with pulmonary arterial hypertension (PAH). The aim of this study was to use the flow propagation velocity (FPV) of early diastolic tricuspid inflow to evaluate exercise tolerance and PAH severity and to predict readmission in patients with SLE. Methods: A total of 66 patients with SLE with or without PAH and 30 healthy control subjects were enrolled. Controls were age-matched to patients with SLE and without PAH. All patients completed the 6-minute walking distance (6MWD) test and underwent standard echocardiography. Tricuspid FPV was measured in the modified parasternal short-axis view using the color M-mode technique. PAH was defined as PASP > 35 mm Hg using the tricuspid regurgitant method. Results: Patients with SLE and PAH had significantly lower tricuspid FPVs and 6MWDs than patients in the other 2 groups (both P values < .001). Tricuspid FPV was well correlated with 6MWD (r = 0.748, P < .001). In multivariate analysis, right atrial pressure was the only independent factor affecting tricuspid FPV (R2 = 0.394, P < .001), and 6MWD was affected only by tricuspid FPV and PASP (R2 = 0.629, P < .001). Patients with SLE who had been readmitted had lower tricuspid FPVs than those who had not (P = .035). Furthermore, FPV ≥ 35.4 cm/s predicted 6MWD ≥ 350 m and a lower 1-year readmission rate with good sensitivity and specificity. Conclusion: The tricuspid FPV technique provides a simple method for predicting exercise tolerance, the severity of PAH, and readmission among patients with SLE.

Original languageEnglish
Pages (from-to)411-417
Number of pages7
JournalJournal of the American Society of Echocardiography
Volume22
Issue number4
DOIs
Publication statusPublished - Apr 1 2009
Externally publishedYes

Fingerprint

Patient Readmission
Exercise Tolerance
Systemic Lupus Erythematosus
Pulmonary Hypertension
Walking
Pulmonary Artery
Blood Pressure
Right Ventricular Dysfunction
Atrial Pressure
Echocardiography
Healthy Volunteers
Multivariate Analysis
Color
Sensitivity and Specificity
Mortality

Keywords

  • 6-minute walking distance
  • Flow propagation velocity
  • Pulmonary arterial hypertension
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Tricuspid Flow Propagation Velocity Predicts Exercise Tolerance and Readmission in Patients With Systemic Lupus Erythematosus. / Cheng, Chin Chang; Huang, Wei Chun; Chiou, Kuan Rau; Hsiao, Shih Hung; Lin, Shih Kai; Lu, Ling Ying; Tseng, Jui Cheng; Hu, Jui Chieh; Mar, Guang Yuan; Chiou, Chuen Wang; Lin, Shoa lin; Liu, Chun Peng.

In: Journal of the American Society of Echocardiography, Vol. 22, No. 4, 01.04.2009, p. 411-417.

Research output: Contribution to journalArticle

Cheng, Chin Chang ; Huang, Wei Chun ; Chiou, Kuan Rau ; Hsiao, Shih Hung ; Lin, Shih Kai ; Lu, Ling Ying ; Tseng, Jui Cheng ; Hu, Jui Chieh ; Mar, Guang Yuan ; Chiou, Chuen Wang ; Lin, Shoa lin ; Liu, Chun Peng. / Tricuspid Flow Propagation Velocity Predicts Exercise Tolerance and Readmission in Patients With Systemic Lupus Erythematosus. In: Journal of the American Society of Echocardiography. 2009 ; Vol. 22, No. 4. pp. 411-417.
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abstract = "Background: Evaluating right ventricular dysfunction, pulmonary artery systolic pressure (PASP), and exercise tolerance is critical in patients with systemic lupus erythematosus (SLE) because of the high mortality rate in such patients with pulmonary arterial hypertension (PAH). The aim of this study was to use the flow propagation velocity (FPV) of early diastolic tricuspid inflow to evaluate exercise tolerance and PAH severity and to predict readmission in patients with SLE. Methods: A total of 66 patients with SLE with or without PAH and 30 healthy control subjects were enrolled. Controls were age-matched to patients with SLE and without PAH. All patients completed the 6-minute walking distance (6MWD) test and underwent standard echocardiography. Tricuspid FPV was measured in the modified parasternal short-axis view using the color M-mode technique. PAH was defined as PASP > 35 mm Hg using the tricuspid regurgitant method. Results: Patients with SLE and PAH had significantly lower tricuspid FPVs and 6MWDs than patients in the other 2 groups (both P values < .001). Tricuspid FPV was well correlated with 6MWD (r = 0.748, P < .001). In multivariate analysis, right atrial pressure was the only independent factor affecting tricuspid FPV (R2 = 0.394, P < .001), and 6MWD was affected only by tricuspid FPV and PASP (R2 = 0.629, P < .001). Patients with SLE who had been readmitted had lower tricuspid FPVs than those who had not (P = .035). Furthermore, FPV ≥ 35.4 cm/s predicted 6MWD ≥ 350 m and a lower 1-year readmission rate with good sensitivity and specificity. Conclusion: The tricuspid FPV technique provides a simple method for predicting exercise tolerance, the severity of PAH, and readmission among patients with SLE.",
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T1 - Tricuspid Flow Propagation Velocity Predicts Exercise Tolerance and Readmission in Patients With Systemic Lupus Erythematosus

AU - Cheng, Chin Chang

AU - Huang, Wei Chun

AU - Chiou, Kuan Rau

AU - Hsiao, Shih Hung

AU - Lin, Shih Kai

AU - Lu, Ling Ying

AU - Tseng, Jui Cheng

AU - Hu, Jui Chieh

AU - Mar, Guang Yuan

AU - Chiou, Chuen Wang

AU - Lin, Shoa lin

AU - Liu, Chun Peng

PY - 2009/4/1

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N2 - Background: Evaluating right ventricular dysfunction, pulmonary artery systolic pressure (PASP), and exercise tolerance is critical in patients with systemic lupus erythematosus (SLE) because of the high mortality rate in such patients with pulmonary arterial hypertension (PAH). The aim of this study was to use the flow propagation velocity (FPV) of early diastolic tricuspid inflow to evaluate exercise tolerance and PAH severity and to predict readmission in patients with SLE. Methods: A total of 66 patients with SLE with or without PAH and 30 healthy control subjects were enrolled. Controls were age-matched to patients with SLE and without PAH. All patients completed the 6-minute walking distance (6MWD) test and underwent standard echocardiography. Tricuspid FPV was measured in the modified parasternal short-axis view using the color M-mode technique. PAH was defined as PASP > 35 mm Hg using the tricuspid regurgitant method. Results: Patients with SLE and PAH had significantly lower tricuspid FPVs and 6MWDs than patients in the other 2 groups (both P values < .001). Tricuspid FPV was well correlated with 6MWD (r = 0.748, P < .001). In multivariate analysis, right atrial pressure was the only independent factor affecting tricuspid FPV (R2 = 0.394, P < .001), and 6MWD was affected only by tricuspid FPV and PASP (R2 = 0.629, P < .001). Patients with SLE who had been readmitted had lower tricuspid FPVs than those who had not (P = .035). Furthermore, FPV ≥ 35.4 cm/s predicted 6MWD ≥ 350 m and a lower 1-year readmission rate with good sensitivity and specificity. Conclusion: The tricuspid FPV technique provides a simple method for predicting exercise tolerance, the severity of PAH, and readmission among patients with SLE.

AB - Background: Evaluating right ventricular dysfunction, pulmonary artery systolic pressure (PASP), and exercise tolerance is critical in patients with systemic lupus erythematosus (SLE) because of the high mortality rate in such patients with pulmonary arterial hypertension (PAH). The aim of this study was to use the flow propagation velocity (FPV) of early diastolic tricuspid inflow to evaluate exercise tolerance and PAH severity and to predict readmission in patients with SLE. Methods: A total of 66 patients with SLE with or without PAH and 30 healthy control subjects were enrolled. Controls were age-matched to patients with SLE and without PAH. All patients completed the 6-minute walking distance (6MWD) test and underwent standard echocardiography. Tricuspid FPV was measured in the modified parasternal short-axis view using the color M-mode technique. PAH was defined as PASP > 35 mm Hg using the tricuspid regurgitant method. Results: Patients with SLE and PAH had significantly lower tricuspid FPVs and 6MWDs than patients in the other 2 groups (both P values < .001). Tricuspid FPV was well correlated with 6MWD (r = 0.748, P < .001). In multivariate analysis, right atrial pressure was the only independent factor affecting tricuspid FPV (R2 = 0.394, P < .001), and 6MWD was affected only by tricuspid FPV and PASP (R2 = 0.629, P < .001). Patients with SLE who had been readmitted had lower tricuspid FPVs than those who had not (P = .035). Furthermore, FPV ≥ 35.4 cm/s predicted 6MWD ≥ 350 m and a lower 1-year readmission rate with good sensitivity and specificity. Conclusion: The tricuspid FPV technique provides a simple method for predicting exercise tolerance, the severity of PAH, and readmission among patients with SLE.

KW - 6-minute walking distance

KW - Flow propagation velocity

KW - Pulmonary arterial hypertension

KW - Systemic lupus erythematosus

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