Tribulus terrestris fruit extract inhibits autophagic flux to diminish cell proliferation and metastatic characteristics of oral cancer cells

Chih Wen Shu, Jing Ru Weng, Hsueh Wei Chang, Pei Feng Liu, Jih Jung Chen, Chien Chi Peng, Jia Wen Huang, Wei Yu Lin, Ching Yu Yen

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Elevated autophagy is highly associated with cancer development and progression. Fruit extracts of several plants inhibit activity of autophagy-related protease ATG4B and autophagy activity in colorectal cancer cells. However, the effects of these plant extracts in oral cancer cells remain unclear. In this study, we found that the extracted Tribulus terrestris fruit (TT-(fr)) and Xanthium strumarium fruit had inhibitory effects on autophagy inhibition in both SAS and TW2.6 oral cancer cells. Moreover, the fruit extracts had differential effects on cell proliferation of oral cancer cells. In addition, the fruit extracts hampered cell migration and invasion of oral cancer cells, particularly in TT-(fr) extracts. Our results indicated that TT-(fr) extracts consistently inhibited autophagic flux, cell growth and metastatic characteristics of oral cancer cells, suggesting TT-(fr) might contain function ingredient to suppress oral cancer cells.

Original languageEnglish
Pages (from-to)1173-1180
Number of pages8
JournalEnvironmental Toxicology
Volume36
Issue number6
DOIs
Publication statusPublished - Jun 2021

Keywords

  • ATG4B
  • autophagy
  • oral cancer
  • plant extract

ASJC Scopus subject areas

  • Toxicology
  • Management, Monitoring, Policy and Law
  • Health, Toxicology and Mutagenesis

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