Tribological process induced conformational transformation of protein may change the friction of cartilage

Chih Hung Chang, Hsu Wei Fang, Huei Ting Huang, Hsuan Liang Liu, Wei Ming Lee, Man Ching Hsieh, Chiang San Chen

Research output: Contribution to journalArticle

5 Citations (Scopus)


In-vitro testing procedures have been successfully developed to investigate the effects of tribological process induced transformation of protein-based lubricant on the friction change of articular cartilages. Serum and albumin solutions were the biological lubricants used in this study. The results indicated that the lubricating ability for cartilages deteriorates after the biological lubricants were articulated between polyethylene and stainless steel materials. In addition, the secondary structure change of the albumin molecule has been characterized after the molecules were articulated by the artificial joint materials. We have provided evidence that the conformational change of protein lubricants leads to the friction increase of articular cartilage.

Original languageEnglish
Pages (from-to)3381-3384
Number of pages4
JournalMaterials Letters
Issue number16
Publication statusPublished - Jun 1 2007
Externally publishedYes



  • Albumin
  • Cartilage
  • Friction
  • Partial joint arthroplasty
  • Tribochemistry

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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