Trends of Gold Nanoparticle-based Drug Delivery System in Cancer Therapy

Giimel Ajnai, Amy Chiu, Tzuchun Kan, Chun Chia Cheng, Teh Hua Tsai, Jungshan Chang

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Following surgical removal of malignant tumors, chemotherapeutic intervention usually is subsequently applied in patients with advanced stages of cancer. Most chemotherapeutic drugs are intravenously injected into patients, leading to systemic cytotoxicity in organs and tissues, including healthy tissue and tumors. Currently, it has been demonstrated that gold nanoparticles can easily penetrate blood vessels and tissue barriers into tumor foci, which indicates gold nanoparticles as a more effective drug carrier with great merits in reducing cytotoxicity and economic burden in patients. Moreover, gold nanoparticles display several unique characterizations with multiple functions in therapeutics, imaging, and surface modification, suggesting gold nanoparticles may become effective antitumor drug carriers. In this review article, we discuss the limitations and applications of gold nanoparticles in surface modification, targeting strategy, and safety considerations.

Original languageEnglish
Pages (from-to)172-178
Number of pages7
JournalJournal of Experimental and Clinical Medicine(Taiwan)
Volume6
Issue number6
DOIs
Publication statusPublished - Dec 1 2014

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Drug Delivery Systems
Gold
Nanoparticles
Drug Carriers
Neoplasms
Therapeutics
Antineoplastic Agents
Blood Vessels
Economics
Safety
Pharmaceutical Preparations

Keywords

  • Gold nanoparticles
  • Nanomedicine
  • Reticuloendothelial system

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Trends of Gold Nanoparticle-based Drug Delivery System in Cancer Therapy. / Ajnai, Giimel; Chiu, Amy; Kan, Tzuchun; Cheng, Chun Chia; Tsai, Teh Hua; Chang, Jungshan.

In: Journal of Experimental and Clinical Medicine(Taiwan), Vol. 6, No. 6, 01.12.2014, p. 172-178.

Research output: Contribution to journalArticle

Ajnai, Giimel ; Chiu, Amy ; Kan, Tzuchun ; Cheng, Chun Chia ; Tsai, Teh Hua ; Chang, Jungshan. / Trends of Gold Nanoparticle-based Drug Delivery System in Cancer Therapy. In: Journal of Experimental and Clinical Medicine(Taiwan). 2014 ; Vol. 6, No. 6. pp. 172-178.
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