Trends in the susceptibility of methicillin-resistant Staphylococcus aureus to nine antimicrobial agents, including ceftobiprole, nemonoxacin, and tyrothricin: Results from the Tigecycline in Vitro Surveillance in Taiwan (TIST) study, 2006-2010

Y. H. Chen, C. Y. Liu, W. C. Ko, C. H. Liao, P. L. Lu, C. H. Huang, C. T. Lu, Y. C. Chuang, S. M. Tsao, Y. S. Chen, Y. C. Liu, W. Y. Chen, T. N. Jang, H. C. Lin, C. M. Chen, Z. Y. Shi, S. C. Pan, J. L. Yang, H. C. Kung, C. E. LiuY. J. Cheng, J. W. Liu, W. Sun, L. S. Wang, K. W. Yu, P. C. Chiang, M. H. Lee, C. M. Lee, G. J. Hsu, P. R. Hsueh

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Abstract

This study investigated the in vitro susceptibilities of methicillin-resistant Staphylococcus aureus (MRSA) to nine antimicrobial agents in Taiwan. A total of 1,725 isolates were obtained from 20 hospitals throughout Taiwan from 2006 to 2010. The minimum inhibitory concentrations (MICs) of the nine agents were determined by the agar dilution method. The MICs of mupirocin and tyrothricin were determined for 223 MRSA isolates collected from 2009 to 2010. For vancomycin, 99.7 % were susceptible; however, 30.0 % (n = 517) exhibited MICs of 2 μg/ml and 0.3 % (n = 6) demonstrated intermediate susceptibility (MICs of 4 μg/ml). Nearly all isolates (≥99.9 %) were susceptible to teicoplanin, linezolid, and daptomycin. The MIC90 values were 2 μg/ml for ceftobiprole and 1 μg/ml for nemonoxacin. The MIC90 values of mupirocin and tyrothricin were 0.12 and 4 μg/ml, respectively. MIC creep was noted for daptomycin during this period, but not for vancomycin, teicoplanin, linezolid, or tigecycline. For isolates with vancomycin MICs of 2 μg/ml, the MIC90 values were 2 μg/ml for teicoplanin, 0.5 μg/ml for daptomycin, and 0.5 μg/ml for tigecycline. Those values were four- to eight-fold higher than those among isolates with vancomycin MICs of 0.5 μg/ml (2, 0.06, and 0.12 μg/ml, respectively). Of the nine MRSA isolates exhibiting non-susceptibility to vancomycin (n = 6), teicoplanin (n = 1), daptomycin (n = 2), or tigecycline (n = 1), all had different pulsotypes, indicating the absence of intra-hospital or inter-hospital spread. The presence of a high proportion of MRSA isolates with elevated MICs (2 μg/ml) and MIC creep of daptomycin might alert clinicians on the therapy for serious MRSA infections in Taiwan.

Original languageEnglish
Pages (from-to)233-239
Number of pages7
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume33
Issue number2
DOIs
Publication statusPublished - Feb 2014

Fingerprint

Tyrothricin
Microbial Sensitivity Tests
Methicillin-Resistant Staphylococcus aureus
Anti-Infective Agents
Taiwan
Daptomycin
Vancomycin
Teicoplanin
Linezolid
Mupirocin
nemonoxacin
tigecycline
In Vitro Techniques
ceftobiprole
Agar

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Trends in the susceptibility of methicillin-resistant Staphylococcus aureus to nine antimicrobial agents, including ceftobiprole, nemonoxacin, and tyrothricin : Results from the Tigecycline in Vitro Surveillance in Taiwan (TIST) study, 2006-2010. / Chen, Y. H.; Liu, C. Y.; Ko, W. C.; Liao, C. H.; Lu, P. L.; Huang, C. H.; Lu, C. T.; Chuang, Y. C.; Tsao, S. M.; Chen, Y. S.; Liu, Y. C.; Chen, W. Y.; Jang, T. N.; Lin, H. C.; Chen, C. M.; Shi, Z. Y.; Pan, S. C.; Yang, J. L.; Kung, H. C.; Liu, C. E.; Cheng, Y. J.; Liu, J. W.; Sun, W.; Wang, L. S.; Yu, K. W.; Chiang, P. C.; Lee, M. H.; Lee, C. M.; Hsu, G. J.; Hsueh, P. R.

In: European Journal of Clinical Microbiology and Infectious Diseases, Vol. 33, No. 2, 02.2014, p. 233-239.

Research output: Contribution to journalArticle

Chen, YH, Liu, CY, Ko, WC, Liao, CH, Lu, PL, Huang, CH, Lu, CT, Chuang, YC, Tsao, SM, Chen, YS, Liu, YC, Chen, WY, Jang, TN, Lin, HC, Chen, CM, Shi, ZY, Pan, SC, Yang, JL, Kung, HC, Liu, CE, Cheng, YJ, Liu, JW, Sun, W, Wang, LS, Yu, KW, Chiang, PC, Lee, MH, Lee, CM, Hsu, GJ & Hsueh, PR 2014, 'Trends in the susceptibility of methicillin-resistant Staphylococcus aureus to nine antimicrobial agents, including ceftobiprole, nemonoxacin, and tyrothricin: Results from the Tigecycline in Vitro Surveillance in Taiwan (TIST) study, 2006-2010', European Journal of Clinical Microbiology and Infectious Diseases, vol. 33, no. 2, pp. 233-239. https://doi.org/10.1007/s10096-013-1949-y
Chen, Y. H. ; Liu, C. Y. ; Ko, W. C. ; Liao, C. H. ; Lu, P. L. ; Huang, C. H. ; Lu, C. T. ; Chuang, Y. C. ; Tsao, S. M. ; Chen, Y. S. ; Liu, Y. C. ; Chen, W. Y. ; Jang, T. N. ; Lin, H. C. ; Chen, C. M. ; Shi, Z. Y. ; Pan, S. C. ; Yang, J. L. ; Kung, H. C. ; Liu, C. E. ; Cheng, Y. J. ; Liu, J. W. ; Sun, W. ; Wang, L. S. ; Yu, K. W. ; Chiang, P. C. ; Lee, M. H. ; Lee, C. M. ; Hsu, G. J. ; Hsueh, P. R. / Trends in the susceptibility of methicillin-resistant Staphylococcus aureus to nine antimicrobial agents, including ceftobiprole, nemonoxacin, and tyrothricin : Results from the Tigecycline in Vitro Surveillance in Taiwan (TIST) study, 2006-2010. In: European Journal of Clinical Microbiology and Infectious Diseases. 2014 ; Vol. 33, No. 2. pp. 233-239.
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abstract = "This study investigated the in vitro susceptibilities of methicillin-resistant Staphylococcus aureus (MRSA) to nine antimicrobial agents in Taiwan. A total of 1,725 isolates were obtained from 20 hospitals throughout Taiwan from 2006 to 2010. The minimum inhibitory concentrations (MICs) of the nine agents were determined by the agar dilution method. The MICs of mupirocin and tyrothricin were determined for 223 MRSA isolates collected from 2009 to 2010. For vancomycin, 99.7 {\%} were susceptible; however, 30.0 {\%} (n = 517) exhibited MICs of 2 μg/ml and 0.3 {\%} (n = 6) demonstrated intermediate susceptibility (MICs of 4 μg/ml). Nearly all isolates (≥99.9 {\%}) were susceptible to teicoplanin, linezolid, and daptomycin. The MIC90 values were 2 μg/ml for ceftobiprole and 1 μg/ml for nemonoxacin. The MIC90 values of mupirocin and tyrothricin were 0.12 and 4 μg/ml, respectively. MIC creep was noted for daptomycin during this period, but not for vancomycin, teicoplanin, linezolid, or tigecycline. For isolates with vancomycin MICs of 2 μg/ml, the MIC90 values were 2 μg/ml for teicoplanin, 0.5 μg/ml for daptomycin, and 0.5 μg/ml for tigecycline. Those values were four- to eight-fold higher than those among isolates with vancomycin MICs of 0.5 μg/ml (2, 0.06, and 0.12 μg/ml, respectively). Of the nine MRSA isolates exhibiting non-susceptibility to vancomycin (n = 6), teicoplanin (n = 1), daptomycin (n = 2), or tigecycline (n = 1), all had different pulsotypes, indicating the absence of intra-hospital or inter-hospital spread. The presence of a high proportion of MRSA isolates with elevated MICs (2 μg/ml) and MIC creep of daptomycin might alert clinicians on the therapy for serious MRSA infections in Taiwan.",
author = "Chen, {Y. H.} and Liu, {C. Y.} and Ko, {W. C.} and Liao, {C. H.} and Lu, {P. L.} and Huang, {C. H.} and Lu, {C. T.} and Chuang, {Y. C.} and Tsao, {S. M.} and Chen, {Y. S.} and Liu, {Y. C.} and Chen, {W. Y.} and Jang, {T. N.} and Lin, {H. C.} and Chen, {C. M.} and Shi, {Z. Y.} and Pan, {S. C.} and Yang, {J. L.} and Kung, {H. C.} and Liu, {C. E.} and Cheng, {Y. J.} and Liu, {J. W.} and W. Sun and Wang, {L. S.} and Yu, {K. W.} and Chiang, {P. C.} and Lee, {M. H.} and Lee, {C. M.} and Hsu, {G. J.} and Hsueh, {P. R.}",
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T1 - Trends in the susceptibility of methicillin-resistant Staphylococcus aureus to nine antimicrobial agents, including ceftobiprole, nemonoxacin, and tyrothricin

T2 - Results from the Tigecycline in Vitro Surveillance in Taiwan (TIST) study, 2006-2010

AU - Chen, Y. H.

AU - Liu, C. Y.

AU - Ko, W. C.

AU - Liao, C. H.

AU - Lu, P. L.

AU - Huang, C. H.

AU - Lu, C. T.

AU - Chuang, Y. C.

AU - Tsao, S. M.

AU - Chen, Y. S.

AU - Liu, Y. C.

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AU - Chen, C. M.

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AU - Pan, S. C.

AU - Yang, J. L.

AU - Kung, H. C.

AU - Liu, C. E.

AU - Cheng, Y. J.

AU - Liu, J. W.

AU - Sun, W.

AU - Wang, L. S.

AU - Yu, K. W.

AU - Chiang, P. C.

AU - Lee, M. H.

AU - Lee, C. M.

AU - Hsu, G. J.

AU - Hsueh, P. R.

PY - 2014/2

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N2 - This study investigated the in vitro susceptibilities of methicillin-resistant Staphylococcus aureus (MRSA) to nine antimicrobial agents in Taiwan. A total of 1,725 isolates were obtained from 20 hospitals throughout Taiwan from 2006 to 2010. The minimum inhibitory concentrations (MICs) of the nine agents were determined by the agar dilution method. The MICs of mupirocin and tyrothricin were determined for 223 MRSA isolates collected from 2009 to 2010. For vancomycin, 99.7 % were susceptible; however, 30.0 % (n = 517) exhibited MICs of 2 μg/ml and 0.3 % (n = 6) demonstrated intermediate susceptibility (MICs of 4 μg/ml). Nearly all isolates (≥99.9 %) were susceptible to teicoplanin, linezolid, and daptomycin. The MIC90 values were 2 μg/ml for ceftobiprole and 1 μg/ml for nemonoxacin. The MIC90 values of mupirocin and tyrothricin were 0.12 and 4 μg/ml, respectively. MIC creep was noted for daptomycin during this period, but not for vancomycin, teicoplanin, linezolid, or tigecycline. For isolates with vancomycin MICs of 2 μg/ml, the MIC90 values were 2 μg/ml for teicoplanin, 0.5 μg/ml for daptomycin, and 0.5 μg/ml for tigecycline. Those values were four- to eight-fold higher than those among isolates with vancomycin MICs of 0.5 μg/ml (2, 0.06, and 0.12 μg/ml, respectively). Of the nine MRSA isolates exhibiting non-susceptibility to vancomycin (n = 6), teicoplanin (n = 1), daptomycin (n = 2), or tigecycline (n = 1), all had different pulsotypes, indicating the absence of intra-hospital or inter-hospital spread. The presence of a high proportion of MRSA isolates with elevated MICs (2 μg/ml) and MIC creep of daptomycin might alert clinicians on the therapy for serious MRSA infections in Taiwan.

AB - This study investigated the in vitro susceptibilities of methicillin-resistant Staphylococcus aureus (MRSA) to nine antimicrobial agents in Taiwan. A total of 1,725 isolates were obtained from 20 hospitals throughout Taiwan from 2006 to 2010. The minimum inhibitory concentrations (MICs) of the nine agents were determined by the agar dilution method. The MICs of mupirocin and tyrothricin were determined for 223 MRSA isolates collected from 2009 to 2010. For vancomycin, 99.7 % were susceptible; however, 30.0 % (n = 517) exhibited MICs of 2 μg/ml and 0.3 % (n = 6) demonstrated intermediate susceptibility (MICs of 4 μg/ml). Nearly all isolates (≥99.9 %) were susceptible to teicoplanin, linezolid, and daptomycin. The MIC90 values were 2 μg/ml for ceftobiprole and 1 μg/ml for nemonoxacin. The MIC90 values of mupirocin and tyrothricin were 0.12 and 4 μg/ml, respectively. MIC creep was noted for daptomycin during this period, but not for vancomycin, teicoplanin, linezolid, or tigecycline. For isolates with vancomycin MICs of 2 μg/ml, the MIC90 values were 2 μg/ml for teicoplanin, 0.5 μg/ml for daptomycin, and 0.5 μg/ml for tigecycline. Those values were four- to eight-fold higher than those among isolates with vancomycin MICs of 0.5 μg/ml (2, 0.06, and 0.12 μg/ml, respectively). Of the nine MRSA isolates exhibiting non-susceptibility to vancomycin (n = 6), teicoplanin (n = 1), daptomycin (n = 2), or tigecycline (n = 1), all had different pulsotypes, indicating the absence of intra-hospital or inter-hospital spread. The presence of a high proportion of MRSA isolates with elevated MICs (2 μg/ml) and MIC creep of daptomycin might alert clinicians on the therapy for serious MRSA infections in Taiwan.

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