Trends in the susceptibility of clinically important resistant bacteria to tigecycline: Results from the tigecycline In Vitro surveillance in Taiwan study, 2006 to 2010

Yen Hsu Chen, Po Liang Lu, Cheng Hua Huang, Chun Hsing Liao, Chin Te Lu, Yin Ching Chuang, Shih Ming Tsao, Yao Shen Chen, Yung Ching Liu, Wei Yu Chen, Tsrang Neng Jang, Hsiu Chen Lin, Chih Ming Chen, Zhi Yuan Shi, Sung Ching Pan, Jia Ling Yang, Hsiang Chi Kung, Chun Eng Liu, Yu Jen Cheng, Jien Wei LiuWu Sun, Lih Shinn Wang, Wen Chien Ko, Kwok Woon Yu, Ping Cherng Chiang, Ming Hsun Lee, Chun Ming Lee, Gwo Jong Hsu, Po Ren Hsueh

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34 Citations (Scopus)

Abstract

The Tigecycline In Vitro Surveillance in Taiwan (TIST) study, a nationwide, prospective surveillance during 2006 to 2010, collected a total of 7,793 clinical isolates, including methicillin-resistant Staphylococcus aureus (MRSA) (n = 1,834), penicillin-resistant Streptococcus pneumoniae (PRSP) (n = 423), vancomycin-resistant enterococci (VRE) (n = 219), extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (n = 1,141), ESBL-producing Klebsiella pneumoniae (n = 1,330), Acinetobacter baumannii (n = 1,645), and Stenotrophomonas maltophilia (n = 903), from different specimens from 20 different hospitals in Taiwan. MICs of tigecycline were determined following the criteria of the U.S. Food and Drug Administration (FDA) and the European Committee on Antimicrobial Susceptibility Testing (EUCAST-2011). Among drug-resistant Gram-positive pathogens, all of the PRSP isolates were susceptible to tigecycline (MIC 90, 0.03 μg/ml), and only one MRSA isolate (MIC 90, 0.5 μg/ml) and three VRE isolates (MIC 90, 0.125 μg/ml) were nonsusceptible to tigecycline. Among the Gram-negative bacteria, the tigecycline susceptibility rates were 99.65% for ESBL-producing E. coli (MIC 90, 0.5 μg/ml) and 96.32% for ESBL-producing K. pneumoniae (MIC 90, 2 μg/ml) when interpreted by FDA criteria but were 98.7% and 85.8%, respectively, when interpreted by EUCAST-2011 criteria. The susceptibility rate for A. baumannii (MIC 90, 4 μg/ml) decreased from 80.9% in 2006 to 55.3% in 2009 but increased to 73.4% in 2010. A bimodal MIC distribution was found among carbapenem-susceptible A. baumannii isolates, and a unimodal MIC distribution was found among carbapenem-nonsusceptible A. baumannii isolates. In Taiwan, tigecycline continues to have excellent in vitro activity against several major clinically important drug-resistant bacteria, with the exception of A. baumannii.

Original languageEnglish
Pages (from-to)1452-1457
Number of pages6
JournalAntimicrobial Agents and Chemotherapy
Volume56
Issue number3
DOIs
Publication statusPublished - Mar 2012

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

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