Trends in the incidence of primary malignant brain tumors in Taiwan and correlation with comorbidities

A population-based study

Ya Jui Lin, Hsiao Yean Chiu, Meng Jiun Chiou, Yin Cheng Huang, Kuo Chen Wei, Chang Fu Kuo, Jun Te Hsu, Pin Yuan Chen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective Primary malignant brain tumors are relatively uncommon, and their incidence and survival rates have seldom been reported. Patients and methods We identified all patients with malignant brain tumors in Taiwan between 1997 and 2012 using the National Health Insurance database. We estimated the stratified incidence of malignant brain tumors by age and sex. We estimated the median 1-, 2-, and 5-year survival, taking comorbidities into account. Trends for incidence and survival were analyzed using Joinpoint regression. The incidence in different geographic areas was also evaluated. Results A total of 7746 men and 5846 women were identified. The incidence of malignant brain tumor was 3.34 (95% CI, 3.09–3.59) per 100,000 person-years in 1997 and 3.82 (95% CI, 3.56–4.08) per 100,000 person-years in 2012. The average annual percentage change (APC) of the standardized incidence over this period was 0.1 (95% CI, −1.9 to 2.2), suggesting a relatively stable incidence. However, the incidence significantly decreased between 1999 and 2012, with an APC of −1.8 [95% CI, −2.5 to −1.0]. One- and 5-year survival was 53.8% (50.0%–57.5%) and 27.5% (24.1%–30.9%) in 1997 and 67.6% (64.3%–70.7%) and 32.8% (29.6%–35.9%) in 2012. The average APC was 1.1 (95% CI, 0.7–1.5) for 1-year survival and 0.2 (95% CI, −1.0–1.4) for 5-year survival. The trend of improvement in the survival rate was seen for short-term but not long-term survival, especially in the group with more comorbidities. Conclusions A slightly decreased trend in incidence of primary malignant brain tumors was observed in Taiwanese general population since 1999. Over the past 15 years, the short-term survival of malignant brain tumors has improved, especially in adults.

Original languageEnglish
Pages (from-to)72-82
Number of pages11
JournalClinical Neurology and Neurosurgery
Volume159
DOIs
Publication statusPublished - Aug 1 2017

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Taiwan
Brain Neoplasms
Comorbidity
Incidence
Population
Survival
Survival Rate
National Health Programs
Databases

Keywords

  • Comorbidity
  • Epidemiology
  • Incidence
  • Primary brain neoplasm
  • Survival

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Trends in the incidence of primary malignant brain tumors in Taiwan and correlation with comorbidities : A population-based study. / Lin, Ya Jui; Chiu, Hsiao Yean; Chiou, Meng Jiun; Huang, Yin Cheng; Wei, Kuo Chen; Kuo, Chang Fu; Hsu, Jun Te; Chen, Pin Yuan.

In: Clinical Neurology and Neurosurgery, Vol. 159, 01.08.2017, p. 72-82.

Research output: Contribution to journalArticle

Lin, Ya Jui ; Chiu, Hsiao Yean ; Chiou, Meng Jiun ; Huang, Yin Cheng ; Wei, Kuo Chen ; Kuo, Chang Fu ; Hsu, Jun Te ; Chen, Pin Yuan. / Trends in the incidence of primary malignant brain tumors in Taiwan and correlation with comorbidities : A population-based study. In: Clinical Neurology and Neurosurgery. 2017 ; Vol. 159. pp. 72-82.
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abstract = "Objective Primary malignant brain tumors are relatively uncommon, and their incidence and survival rates have seldom been reported. Patients and methods We identified all patients with malignant brain tumors in Taiwan between 1997 and 2012 using the National Health Insurance database. We estimated the stratified incidence of malignant brain tumors by age and sex. We estimated the median 1-, 2-, and 5-year survival, taking comorbidities into account. Trends for incidence and survival were analyzed using Joinpoint regression. The incidence in different geographic areas was also evaluated. Results A total of 7746 men and 5846 women were identified. The incidence of malignant brain tumor was 3.34 (95{\%} CI, 3.09–3.59) per 100,000 person-years in 1997 and 3.82 (95{\%} CI, 3.56–4.08) per 100,000 person-years in 2012. The average annual percentage change (APC) of the standardized incidence over this period was 0.1 (95{\%} CI, −1.9 to 2.2), suggesting a relatively stable incidence. However, the incidence significantly decreased between 1999 and 2012, with an APC of −1.8 [95{\%} CI, −2.5 to −1.0]. One- and 5-year survival was 53.8{\%} (50.0{\%}–57.5{\%}) and 27.5{\%} (24.1{\%}–30.9{\%}) in 1997 and 67.6{\%} (64.3{\%}–70.7{\%}) and 32.8{\%} (29.6{\%}–35.9{\%}) in 2012. The average APC was 1.1 (95{\%} CI, 0.7–1.5) for 1-year survival and 0.2 (95{\%} CI, −1.0–1.4) for 5-year survival. The trend of improvement in the survival rate was seen for short-term but not long-term survival, especially in the group with more comorbidities. Conclusions A slightly decreased trend in incidence of primary malignant brain tumors was observed in Taiwanese general population since 1999. Over the past 15 years, the short-term survival of malignant brain tumors has improved, especially in adults.",
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T1 - Trends in the incidence of primary malignant brain tumors in Taiwan and correlation with comorbidities

T2 - A population-based study

AU - Lin, Ya Jui

AU - Chiu, Hsiao Yean

AU - Chiou, Meng Jiun

AU - Huang, Yin Cheng

AU - Wei, Kuo Chen

AU - Kuo, Chang Fu

AU - Hsu, Jun Te

AU - Chen, Pin Yuan

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Objective Primary malignant brain tumors are relatively uncommon, and their incidence and survival rates have seldom been reported. Patients and methods We identified all patients with malignant brain tumors in Taiwan between 1997 and 2012 using the National Health Insurance database. We estimated the stratified incidence of malignant brain tumors by age and sex. We estimated the median 1-, 2-, and 5-year survival, taking comorbidities into account. Trends for incidence and survival were analyzed using Joinpoint regression. The incidence in different geographic areas was also evaluated. Results A total of 7746 men and 5846 women were identified. The incidence of malignant brain tumor was 3.34 (95% CI, 3.09–3.59) per 100,000 person-years in 1997 and 3.82 (95% CI, 3.56–4.08) per 100,000 person-years in 2012. The average annual percentage change (APC) of the standardized incidence over this period was 0.1 (95% CI, −1.9 to 2.2), suggesting a relatively stable incidence. However, the incidence significantly decreased between 1999 and 2012, with an APC of −1.8 [95% CI, −2.5 to −1.0]. One- and 5-year survival was 53.8% (50.0%–57.5%) and 27.5% (24.1%–30.9%) in 1997 and 67.6% (64.3%–70.7%) and 32.8% (29.6%–35.9%) in 2012. The average APC was 1.1 (95% CI, 0.7–1.5) for 1-year survival and 0.2 (95% CI, −1.0–1.4) for 5-year survival. The trend of improvement in the survival rate was seen for short-term but not long-term survival, especially in the group with more comorbidities. Conclusions A slightly decreased trend in incidence of primary malignant brain tumors was observed in Taiwanese general population since 1999. Over the past 15 years, the short-term survival of malignant brain tumors has improved, especially in adults.

AB - Objective Primary malignant brain tumors are relatively uncommon, and their incidence and survival rates have seldom been reported. Patients and methods We identified all patients with malignant brain tumors in Taiwan between 1997 and 2012 using the National Health Insurance database. We estimated the stratified incidence of malignant brain tumors by age and sex. We estimated the median 1-, 2-, and 5-year survival, taking comorbidities into account. Trends for incidence and survival were analyzed using Joinpoint regression. The incidence in different geographic areas was also evaluated. Results A total of 7746 men and 5846 women were identified. The incidence of malignant brain tumor was 3.34 (95% CI, 3.09–3.59) per 100,000 person-years in 1997 and 3.82 (95% CI, 3.56–4.08) per 100,000 person-years in 2012. The average annual percentage change (APC) of the standardized incidence over this period was 0.1 (95% CI, −1.9 to 2.2), suggesting a relatively stable incidence. However, the incidence significantly decreased between 1999 and 2012, with an APC of −1.8 [95% CI, −2.5 to −1.0]. One- and 5-year survival was 53.8% (50.0%–57.5%) and 27.5% (24.1%–30.9%) in 1997 and 67.6% (64.3%–70.7%) and 32.8% (29.6%–35.9%) in 2012. The average APC was 1.1 (95% CI, 0.7–1.5) for 1-year survival and 0.2 (95% CI, −1.0–1.4) for 5-year survival. The trend of improvement in the survival rate was seen for short-term but not long-term survival, especially in the group with more comorbidities. Conclusions A slightly decreased trend in incidence of primary malignant brain tumors was observed in Taiwanese general population since 1999. Over the past 15 years, the short-term survival of malignant brain tumors has improved, especially in adults.

KW - Comorbidity

KW - Epidemiology

KW - Incidence

KW - Primary brain neoplasm

KW - Survival

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