Trends in the antimicrobial susceptibilities and serotypes of Streptococcus pneumoniae: Results from the Tigecycline in Vitro Surveillance in Taiwan (TIST) study, 2006-2010

Hsih Yeh Tsai, Yen Hsu Chen, Chun Hsing Liao, Po Liang Lu, Cheng Hua Huang, Chin Te Lu, Yin Ching Chuang, Shih Ming Tsao, Yao Shen Chen, Yung Ching Liu, Wei Yu Chen, Tsrang Neng Jang, Hsiu Chen Lin, Chih Ming Chen, Zhi Yuan Shi, Sung Ching Pan, Jia Ling Yang, Hsiang Chi Kung, Chun Eng Liu, Yu Jen ChengJien Wei Liu, Wu Sun, Lih Shinn Wang, Wen Chien Ko, Kwok Woon Yu, Ping Cherng Chiang, Ming Hsun Lee, Chun Ming Lee, Gwo Jong Hsu, Po Ren Hsueh

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Isolates of Streptococcus pneumoniae (n = 530) were collected from 20 hospitals in different parts of Taiwan from 2006 to 2010. MICs to 16 antimicrobial agents were determined by broth dilution method and serotypes were identified by latex agglutination. Based on meningitis (non-meningitis) criteria established by the CLSI, 11.7% (63.2%) of all isolates were susceptible to penicillin and 46.0% (83.8%) were susceptible to ceftriaxone. Of the isolates, 94.3% were non-susceptible to azithromycin and 5.8% and 7.2% were non-susceptible to moxifloxacin and levofloxacin, respectively. Susceptibility to penicillin by meningitis criteria increased significantly (P = 0.0012) with year, and that to clindamycin and amoxicillin/clavulanic acid declined significantly (P <0.05). Six major serotypes were found, namely 19F (24.0%), 23F (18.5%), 14 (13.6%), 6B (12.5%), 19A (7.5%) and 3 (5.1%). Prevalence of serotypes 19F and 14 remained stationary, that of serotype 6B decreased significantly (P <0.0001) and that of serotype 19A increased significantly (P <0.0001) with year. The coverage rate of PCV-7 among the pneumococcal isolates declined from 80.5% in 2006 to 50% in 2010 (P <0.0001) and that of PCV-13 declined from 91.5% in 2009 to 75% in 2010. The non-susceptibility rate to levofloxacin was highest among serotype 23F isolates (13.3%) and lowest among serotype 19A isolates (2.5%). Rates of resistance to the four agents penicillin, ceftriaxone, azithromycin and clindamycin were highest among serotype 19A isolates (70.0%) and 23F isolates (49.0%). All serotype 3 isolates were susceptible to four of the most commonly used antibiotics (penicillin, ceftriaxone, azithromycin and levofloxacin).

Original languageEnglish
Pages (from-to)312-316
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Volume42
Issue number4
DOIs
Publication statusPublished - Oct 2013

Fingerprint

Streptococcus pneumoniae
Taiwan
Penicillins
Levofloxacin
Azithromycin
Ceftriaxone
Clindamycin
Meningitis
tigecycline
In Vitro Techniques
Serogroup
Amoxicillin-Potassium Clavulanate Combination
Agglutination
Latex
Anti-Infective Agents

Keywords

  • Antimicrobial susceptibility
  • Serotypes
  • Streptococcus pneumoniae
  • Taiwan
  • TIST

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Trends in the antimicrobial susceptibilities and serotypes of Streptococcus pneumoniae : Results from the Tigecycline in Vitro Surveillance in Taiwan (TIST) study, 2006-2010. / Tsai, Hsih Yeh; Chen, Yen Hsu; Liao, Chun Hsing; Lu, Po Liang; Huang, Cheng Hua; Lu, Chin Te; Chuang, Yin Ching; Tsao, Shih Ming; Chen, Yao Shen; Liu, Yung Ching; Chen, Wei Yu; Jang, Tsrang Neng; Lin, Hsiu Chen; Chen, Chih Ming; Shi, Zhi Yuan; Pan, Sung Ching; Yang, Jia Ling; Kung, Hsiang Chi; Liu, Chun Eng; Cheng, Yu Jen; Liu, Jien Wei; Sun, Wu; Wang, Lih Shinn; Ko, Wen Chien; Yu, Kwok Woon; Chiang, Ping Cherng; Lee, Ming Hsun; Lee, Chun Ming; Hsu, Gwo Jong; Hsueh, Po Ren.

In: International Journal of Antimicrobial Agents, Vol. 42, No. 4, 10.2013, p. 312-316.

Research output: Contribution to journalArticle

Tsai, HY, Chen, YH, Liao, CH, Lu, PL, Huang, CH, Lu, CT, Chuang, YC, Tsao, SM, Chen, YS, Liu, YC, Chen, WY, Jang, TN, Lin, HC, Chen, CM, Shi, ZY, Pan, SC, Yang, JL, Kung, HC, Liu, CE, Cheng, YJ, Liu, JW, Sun, W, Wang, LS, Ko, WC, Yu, KW, Chiang, PC, Lee, MH, Lee, CM, Hsu, GJ & Hsueh, PR 2013, 'Trends in the antimicrobial susceptibilities and serotypes of Streptococcus pneumoniae: Results from the Tigecycline in Vitro Surveillance in Taiwan (TIST) study, 2006-2010', International Journal of Antimicrobial Agents, vol. 42, no. 4, pp. 312-316. https://doi.org/10.1016/j.ijantimicag.2013.05.013
Tsai, Hsih Yeh ; Chen, Yen Hsu ; Liao, Chun Hsing ; Lu, Po Liang ; Huang, Cheng Hua ; Lu, Chin Te ; Chuang, Yin Ching ; Tsao, Shih Ming ; Chen, Yao Shen ; Liu, Yung Ching ; Chen, Wei Yu ; Jang, Tsrang Neng ; Lin, Hsiu Chen ; Chen, Chih Ming ; Shi, Zhi Yuan ; Pan, Sung Ching ; Yang, Jia Ling ; Kung, Hsiang Chi ; Liu, Chun Eng ; Cheng, Yu Jen ; Liu, Jien Wei ; Sun, Wu ; Wang, Lih Shinn ; Ko, Wen Chien ; Yu, Kwok Woon ; Chiang, Ping Cherng ; Lee, Ming Hsun ; Lee, Chun Ming ; Hsu, Gwo Jong ; Hsueh, Po Ren. / Trends in the antimicrobial susceptibilities and serotypes of Streptococcus pneumoniae : Results from the Tigecycline in Vitro Surveillance in Taiwan (TIST) study, 2006-2010. In: International Journal of Antimicrobial Agents. 2013 ; Vol. 42, No. 4. pp. 312-316.
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abstract = "Isolates of Streptococcus pneumoniae (n = 530) were collected from 20 hospitals in different parts of Taiwan from 2006 to 2010. MICs to 16 antimicrobial agents were determined by broth dilution method and serotypes were identified by latex agglutination. Based on meningitis (non-meningitis) criteria established by the CLSI, 11.7{\%} (63.2{\%}) of all isolates were susceptible to penicillin and 46.0{\%} (83.8{\%}) were susceptible to ceftriaxone. Of the isolates, 94.3{\%} were non-susceptible to azithromycin and 5.8{\%} and 7.2{\%} were non-susceptible to moxifloxacin and levofloxacin, respectively. Susceptibility to penicillin by meningitis criteria increased significantly (P = 0.0012) with year, and that to clindamycin and amoxicillin/clavulanic acid declined significantly (P <0.05). Six major serotypes were found, namely 19F (24.0{\%}), 23F (18.5{\%}), 14 (13.6{\%}), 6B (12.5{\%}), 19A (7.5{\%}) and 3 (5.1{\%}). Prevalence of serotypes 19F and 14 remained stationary, that of serotype 6B decreased significantly (P <0.0001) and that of serotype 19A increased significantly (P <0.0001) with year. The coverage rate of PCV-7 among the pneumococcal isolates declined from 80.5{\%} in 2006 to 50{\%} in 2010 (P <0.0001) and that of PCV-13 declined from 91.5{\%} in 2009 to 75{\%} in 2010. The non-susceptibility rate to levofloxacin was highest among serotype 23F isolates (13.3{\%}) and lowest among serotype 19A isolates (2.5{\%}). Rates of resistance to the four agents penicillin, ceftriaxone, azithromycin and clindamycin were highest among serotype 19A isolates (70.0{\%}) and 23F isolates (49.0{\%}). All serotype 3 isolates were susceptible to four of the most commonly used antibiotics (penicillin, ceftriaxone, azithromycin and levofloxacin).",
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T1 - Trends in the antimicrobial susceptibilities and serotypes of Streptococcus pneumoniae

T2 - Results from the Tigecycline in Vitro Surveillance in Taiwan (TIST) study, 2006-2010

AU - Tsai, Hsih Yeh

AU - Chen, Yen Hsu

AU - Liao, Chun Hsing

AU - Lu, Po Liang

AU - Huang, Cheng Hua

AU - Lu, Chin Te

AU - Chuang, Yin Ching

AU - Tsao, Shih Ming

AU - Chen, Yao Shen

AU - Liu, Yung Ching

AU - Chen, Wei Yu

AU - Jang, Tsrang Neng

AU - Lin, Hsiu Chen

AU - Chen, Chih Ming

AU - Shi, Zhi Yuan

AU - Pan, Sung Ching

AU - Yang, Jia Ling

AU - Kung, Hsiang Chi

AU - Liu, Chun Eng

AU - Cheng, Yu Jen

AU - Liu, Jien Wei

AU - Sun, Wu

AU - Wang, Lih Shinn

AU - Ko, Wen Chien

AU - Yu, Kwok Woon

AU - Chiang, Ping Cherng

AU - Lee, Ming Hsun

AU - Lee, Chun Ming

AU - Hsu, Gwo Jong

AU - Hsueh, Po Ren

PY - 2013/10

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N2 - Isolates of Streptococcus pneumoniae (n = 530) were collected from 20 hospitals in different parts of Taiwan from 2006 to 2010. MICs to 16 antimicrobial agents were determined by broth dilution method and serotypes were identified by latex agglutination. Based on meningitis (non-meningitis) criteria established by the CLSI, 11.7% (63.2%) of all isolates were susceptible to penicillin and 46.0% (83.8%) were susceptible to ceftriaxone. Of the isolates, 94.3% were non-susceptible to azithromycin and 5.8% and 7.2% were non-susceptible to moxifloxacin and levofloxacin, respectively. Susceptibility to penicillin by meningitis criteria increased significantly (P = 0.0012) with year, and that to clindamycin and amoxicillin/clavulanic acid declined significantly (P <0.05). Six major serotypes were found, namely 19F (24.0%), 23F (18.5%), 14 (13.6%), 6B (12.5%), 19A (7.5%) and 3 (5.1%). Prevalence of serotypes 19F and 14 remained stationary, that of serotype 6B decreased significantly (P <0.0001) and that of serotype 19A increased significantly (P <0.0001) with year. The coverage rate of PCV-7 among the pneumococcal isolates declined from 80.5% in 2006 to 50% in 2010 (P <0.0001) and that of PCV-13 declined from 91.5% in 2009 to 75% in 2010. The non-susceptibility rate to levofloxacin was highest among serotype 23F isolates (13.3%) and lowest among serotype 19A isolates (2.5%). Rates of resistance to the four agents penicillin, ceftriaxone, azithromycin and clindamycin were highest among serotype 19A isolates (70.0%) and 23F isolates (49.0%). All serotype 3 isolates were susceptible to four of the most commonly used antibiotics (penicillin, ceftriaxone, azithromycin and levofloxacin).

AB - Isolates of Streptococcus pneumoniae (n = 530) were collected from 20 hospitals in different parts of Taiwan from 2006 to 2010. MICs to 16 antimicrobial agents were determined by broth dilution method and serotypes were identified by latex agglutination. Based on meningitis (non-meningitis) criteria established by the CLSI, 11.7% (63.2%) of all isolates were susceptible to penicillin and 46.0% (83.8%) were susceptible to ceftriaxone. Of the isolates, 94.3% were non-susceptible to azithromycin and 5.8% and 7.2% were non-susceptible to moxifloxacin and levofloxacin, respectively. Susceptibility to penicillin by meningitis criteria increased significantly (P = 0.0012) with year, and that to clindamycin and amoxicillin/clavulanic acid declined significantly (P <0.05). Six major serotypes were found, namely 19F (24.0%), 23F (18.5%), 14 (13.6%), 6B (12.5%), 19A (7.5%) and 3 (5.1%). Prevalence of serotypes 19F and 14 remained stationary, that of serotype 6B decreased significantly (P <0.0001) and that of serotype 19A increased significantly (P <0.0001) with year. The coverage rate of PCV-7 among the pneumococcal isolates declined from 80.5% in 2006 to 50% in 2010 (P <0.0001) and that of PCV-13 declined from 91.5% in 2009 to 75% in 2010. The non-susceptibility rate to levofloxacin was highest among serotype 23F isolates (13.3%) and lowest among serotype 19A isolates (2.5%). Rates of resistance to the four agents penicillin, ceftriaxone, azithromycin and clindamycin were highest among serotype 19A isolates (70.0%) and 23F isolates (49.0%). All serotype 3 isolates were susceptible to four of the most commonly used antibiotics (penicillin, ceftriaxone, azithromycin and levofloxacin).

KW - Antimicrobial susceptibility

KW - Serotypes

KW - Streptococcus pneumoniae

KW - Taiwan

KW - TIST

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