Abstract
Isolates of Streptococcus pneumoniae (n = 530) were collected from 20 hospitals in different parts of Taiwan from 2006 to 2010. MICs to 16 antimicrobial agents were determined by broth dilution method and serotypes were identified by latex agglutination. Based on meningitis (non-meningitis) criteria established by the CLSI, 11.7% (63.2%) of all isolates were susceptible to penicillin and 46.0% (83.8%) were susceptible to ceftriaxone. Of the isolates, 94.3% were non-susceptible to azithromycin and 5.8% and 7.2% were non-susceptible to moxifloxacin and levofloxacin, respectively. Susceptibility to penicillin by meningitis criteria increased significantly (P = 0.0012) with year, and that to clindamycin and amoxicillin/clavulanic acid declined significantly (P <0.05). Six major serotypes were found, namely 19F (24.0%), 23F (18.5%), 14 (13.6%), 6B (12.5%), 19A (7.5%) and 3 (5.1%). Prevalence of serotypes 19F and 14 remained stationary, that of serotype 6B decreased significantly (P <0.0001) and that of serotype 19A increased significantly (P <0.0001) with year. The coverage rate of PCV-7 among the pneumococcal isolates declined from 80.5% in 2006 to 50% in 2010 (P <0.0001) and that of PCV-13 declined from 91.5% in 2009 to 75% in 2010. The non-susceptibility rate to levofloxacin was highest among serotype 23F isolates (13.3%) and lowest among serotype 19A isolates (2.5%). Rates of resistance to the four agents penicillin, ceftriaxone, azithromycin and clindamycin were highest among serotype 19A isolates (70.0%) and 23F isolates (49.0%). All serotype 3 isolates were susceptible to four of the most commonly used antibiotics (penicillin, ceftriaxone, azithromycin and levofloxacin).
| Original language | English |
|---|---|
| Pages (from-to) | 312-316 |
| Number of pages | 5 |
| Journal | International Journal of Antimicrobial Agents |
| Volume | 42 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Oct 2013 |
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Keywords
- Antimicrobial susceptibility
- Serotypes
- Streptococcus pneumoniae
- Taiwan
- TIST
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases
- Pharmacology (medical)
Cite this
Trends in the antimicrobial susceptibilities and serotypes of Streptococcus pneumoniae : Results from the Tigecycline in Vitro Surveillance in Taiwan (TIST) study, 2006-2010. / Tsai, Hsih Yeh; Chen, Yen Hsu; Liao, Chun Hsing; Lu, Po Liang; Huang, Cheng Hua; Lu, Chin Te; Chuang, Yin Ching; Tsao, Shih Ming; Chen, Yao Shen; Liu, Yung Ching; Chen, Wei Yu; Jang, Tsrang Neng; Lin, Hsiu Chen; Chen, Chih Ming; Shi, Zhi Yuan; Pan, Sung Ching; Yang, Jia Ling; Kung, Hsiang Chi; Liu, Chun Eng; Cheng, Yu Jen; Liu, Jien Wei; Sun, Wu; Wang, Lih Shinn; Ko, Wen Chien; Yu, Kwok Woon; Chiang, Ping Cherng; Lee, Ming Hsun; Lee, Chun Ming; Hsu, Gwo Jong; Hsueh, Po Ren.
In: International Journal of Antimicrobial Agents, Vol. 42, No. 4, 10.2013, p. 312-316.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Trends in the antimicrobial susceptibilities and serotypes of Streptococcus pneumoniae
T2 - Results from the Tigecycline in Vitro Surveillance in Taiwan (TIST) study, 2006-2010
AU - Tsai, Hsih Yeh
AU - Chen, Yen Hsu
AU - Liao, Chun Hsing
AU - Lu, Po Liang
AU - Huang, Cheng Hua
AU - Lu, Chin Te
AU - Chuang, Yin Ching
AU - Tsao, Shih Ming
AU - Chen, Yao Shen
AU - Liu, Yung Ching
AU - Chen, Wei Yu
AU - Jang, Tsrang Neng
AU - Lin, Hsiu Chen
AU - Chen, Chih Ming
AU - Shi, Zhi Yuan
AU - Pan, Sung Ching
AU - Yang, Jia Ling
AU - Kung, Hsiang Chi
AU - Liu, Chun Eng
AU - Cheng, Yu Jen
AU - Liu, Jien Wei
AU - Sun, Wu
AU - Wang, Lih Shinn
AU - Ko, Wen Chien
AU - Yu, Kwok Woon
AU - Chiang, Ping Cherng
AU - Lee, Ming Hsun
AU - Lee, Chun Ming
AU - Hsu, Gwo Jong
AU - Hsueh, Po Ren
PY - 2013/10
Y1 - 2013/10
N2 - Isolates of Streptococcus pneumoniae (n = 530) were collected from 20 hospitals in different parts of Taiwan from 2006 to 2010. MICs to 16 antimicrobial agents were determined by broth dilution method and serotypes were identified by latex agglutination. Based on meningitis (non-meningitis) criteria established by the CLSI, 11.7% (63.2%) of all isolates were susceptible to penicillin and 46.0% (83.8%) were susceptible to ceftriaxone. Of the isolates, 94.3% were non-susceptible to azithromycin and 5.8% and 7.2% were non-susceptible to moxifloxacin and levofloxacin, respectively. Susceptibility to penicillin by meningitis criteria increased significantly (P = 0.0012) with year, and that to clindamycin and amoxicillin/clavulanic acid declined significantly (P <0.05). Six major serotypes were found, namely 19F (24.0%), 23F (18.5%), 14 (13.6%), 6B (12.5%), 19A (7.5%) and 3 (5.1%). Prevalence of serotypes 19F and 14 remained stationary, that of serotype 6B decreased significantly (P <0.0001) and that of serotype 19A increased significantly (P <0.0001) with year. The coverage rate of PCV-7 among the pneumococcal isolates declined from 80.5% in 2006 to 50% in 2010 (P <0.0001) and that of PCV-13 declined from 91.5% in 2009 to 75% in 2010. The non-susceptibility rate to levofloxacin was highest among serotype 23F isolates (13.3%) and lowest among serotype 19A isolates (2.5%). Rates of resistance to the four agents penicillin, ceftriaxone, azithromycin and clindamycin were highest among serotype 19A isolates (70.0%) and 23F isolates (49.0%). All serotype 3 isolates were susceptible to four of the most commonly used antibiotics (penicillin, ceftriaxone, azithromycin and levofloxacin).
AB - Isolates of Streptococcus pneumoniae (n = 530) were collected from 20 hospitals in different parts of Taiwan from 2006 to 2010. MICs to 16 antimicrobial agents were determined by broth dilution method and serotypes were identified by latex agglutination. Based on meningitis (non-meningitis) criteria established by the CLSI, 11.7% (63.2%) of all isolates were susceptible to penicillin and 46.0% (83.8%) were susceptible to ceftriaxone. Of the isolates, 94.3% were non-susceptible to azithromycin and 5.8% and 7.2% were non-susceptible to moxifloxacin and levofloxacin, respectively. Susceptibility to penicillin by meningitis criteria increased significantly (P = 0.0012) with year, and that to clindamycin and amoxicillin/clavulanic acid declined significantly (P <0.05). Six major serotypes were found, namely 19F (24.0%), 23F (18.5%), 14 (13.6%), 6B (12.5%), 19A (7.5%) and 3 (5.1%). Prevalence of serotypes 19F and 14 remained stationary, that of serotype 6B decreased significantly (P <0.0001) and that of serotype 19A increased significantly (P <0.0001) with year. The coverage rate of PCV-7 among the pneumococcal isolates declined from 80.5% in 2006 to 50% in 2010 (P <0.0001) and that of PCV-13 declined from 91.5% in 2009 to 75% in 2010. The non-susceptibility rate to levofloxacin was highest among serotype 23F isolates (13.3%) and lowest among serotype 19A isolates (2.5%). Rates of resistance to the four agents penicillin, ceftriaxone, azithromycin and clindamycin were highest among serotype 19A isolates (70.0%) and 23F isolates (49.0%). All serotype 3 isolates were susceptible to four of the most commonly used antibiotics (penicillin, ceftriaxone, azithromycin and levofloxacin).
KW - Antimicrobial susceptibility
KW - Serotypes
KW - Streptococcus pneumoniae
KW - Taiwan
KW - TIST
UR - http://www.scopus.com/inward/record.url?scp=84884699725&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884699725&partnerID=8YFLogxK
U2 - 10.1016/j.ijantimicag.2013.05.013
DO - 10.1016/j.ijantimicag.2013.05.013
M3 - Article
C2 - 23849332
AN - SCOPUS:84884699725
VL - 42
SP - 312
EP - 316
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
SN - 0924-8579
IS - 4
ER -