Trends in susceptibility of vancomycin-resistant Enterococcus faecium to tigecycline, daptomycin, and linezolid and molecular epidemiology of the isolates

Results from the Tigecycline in Vitro Surveillance in Taiwan (TIST) study, 2006 to 2010

Hsih Yeh Tsai, Chun Hsing Liao, Yen Hsu Chen, Po Liang Lu, Cheng Hua Huang, Chin Te Lu, Yin Ching Chuang, Shih Ming Tsao, Yao Shen Chen, Yung Ching Liu, Wei Yu Chen, Tsrang Neng Jang, Hsiu Chen Lin, Chih Ming Chen, Zhi Yuan Shi, Sung Ching Pan, Jia Ling Yang, Hsiang Chi Kung, Chun Eng Liu, Yu Jen Cheng & 10 others Jien Wei Liu, Wu Sun, Lih Shinn Wang, Wen Chien Ko, Kwok Woon Yu, Ping Cherng Chiang, Ming Hsun Lee, Chun Ming Lee, Gwo Jong Hsu, Po Ren Hsueh

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Among the 219 vancomycin-resistant Enterococcus faecium isolates collected in 20 Taiwanese hospitals from 2006 to 2010, all were susceptible to linezolid and daptomycin, and 98.6% were susceptible to tigecycline. There was a shift toward higher tigecycline MIC values (MIC90s) from 2006-2007 (0.06 μg/ml) to 2008-2010 (0.12 μg/ml). The MIC90s of daptomycin and linezolid remained stationary. Although pulsotypes among the isolates from the 20 hospitals varied, intrahospital spreading of several clones was identified in 13 hospitals.

Original languageEnglish
Pages (from-to)3402-3405
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume56
Issue number6
DOIs
Publication statusPublished - Jun 2012

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Linezolid
Daptomycin
Enterococcus faecium
Molecular Epidemiology
Taiwan
Clone Cells
Vancomycin-Resistant Enterococci
tigecycline
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Trends in susceptibility of vancomycin-resistant Enterococcus faecium to tigecycline, daptomycin, and linezolid and molecular epidemiology of the isolates : Results from the Tigecycline in Vitro Surveillance in Taiwan (TIST) study, 2006 to 2010. / Tsai, Hsih Yeh; Liao, Chun Hsing; Chen, Yen Hsu; Lu, Po Liang; Huang, Cheng Hua; Lu, Chin Te; Chuang, Yin Ching; Tsao, Shih Ming; Chen, Yao Shen; Liu, Yung Ching; Chen, Wei Yu; Jang, Tsrang Neng; Lin, Hsiu Chen; Chen, Chih Ming; Shi, Zhi Yuan; Pan, Sung Ching; Yang, Jia Ling; Kung, Hsiang Chi; Liu, Chun Eng; Cheng, Yu Jen; Liu, Jien Wei; Sun, Wu; Wang, Lih Shinn; Ko, Wen Chien; Yu, Kwok Woon; Chiang, Ping Cherng; Lee, Ming Hsun; Lee, Chun Ming; Hsu, Gwo Jong; Hsueh, Po Ren.

In: Antimicrobial Agents and Chemotherapy, Vol. 56, No. 6, 06.2012, p. 3402-3405.

Research output: Contribution to journalArticle

Tsai, HY, Liao, CH, Chen, YH, Lu, PL, Huang, CH, Lu, CT, Chuang, YC, Tsao, SM, Chen, YS, Liu, YC, Chen, WY, Jang, TN, Lin, HC, Chen, CM, Shi, ZY, Pan, SC, Yang, JL, Kung, HC, Liu, CE, Cheng, YJ, Liu, JW, Sun, W, Wang, LS, Ko, WC, Yu, KW, Chiang, PC, Lee, MH, Lee, CM, Hsu, GJ & Hsueh, PR 2012, 'Trends in susceptibility of vancomycin-resistant Enterococcus faecium to tigecycline, daptomycin, and linezolid and molecular epidemiology of the isolates: Results from the Tigecycline in Vitro Surveillance in Taiwan (TIST) study, 2006 to 2010', Antimicrobial Agents and Chemotherapy, vol. 56, no. 6, pp. 3402-3405. https://doi.org/10.1128/AAC.00533-12
Tsai, Hsih Yeh ; Liao, Chun Hsing ; Chen, Yen Hsu ; Lu, Po Liang ; Huang, Cheng Hua ; Lu, Chin Te ; Chuang, Yin Ching ; Tsao, Shih Ming ; Chen, Yao Shen ; Liu, Yung Ching ; Chen, Wei Yu ; Jang, Tsrang Neng ; Lin, Hsiu Chen ; Chen, Chih Ming ; Shi, Zhi Yuan ; Pan, Sung Ching ; Yang, Jia Ling ; Kung, Hsiang Chi ; Liu, Chun Eng ; Cheng, Yu Jen ; Liu, Jien Wei ; Sun, Wu ; Wang, Lih Shinn ; Ko, Wen Chien ; Yu, Kwok Woon ; Chiang, Ping Cherng ; Lee, Ming Hsun ; Lee, Chun Ming ; Hsu, Gwo Jong ; Hsueh, Po Ren. / Trends in susceptibility of vancomycin-resistant Enterococcus faecium to tigecycline, daptomycin, and linezolid and molecular epidemiology of the isolates : Results from the Tigecycline in Vitro Surveillance in Taiwan (TIST) study, 2006 to 2010. In: Antimicrobial Agents and Chemotherapy. 2012 ; Vol. 56, No. 6. pp. 3402-3405.
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