Trends and predictors of changes in pulmonary function after treatment for pulmonary tuberculosis

Kuei Pin Chung, Jung Yueh Chen, Chih Hsin Lee, Huey Dong Wu, Jann Yuan Wang, Li Na Lee, Chong Jen Yu, Pan Chyr Yang

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

OBJECTIVES: The present study aimed to investigate the trends in changes in pulmonary function and the risk factors for pulmonary function deterioration in patients with pulmonary tuberculosis after completing treatment. INTRODUCTION: Patients usually have pulmonary function abnormalities after completing treatment for pulmonary tuberculosis. The time course for changes in pulmonary function and the risk factors for deterioration have not been well studied. METHODS: A total of 115 patients with 162 pulmonary function results were analyzed. We retrieved demographic and clinical data, radiographic scores, bacteriological data, and pulmonary function data. A generalized additive model with a locally weighted scatterplot smoothing technique was used to evaluate the trends in changes in pulmonary function. A generalized estimating equation model was used to determine the risk factors associated with deterioration of pulmonary function. RESULTS: The median interval between the end of anti-tuberculosis treatment and the pulmonary function test was 16 months (range: 0 to 112 months). The nadir of pulmonary function occurred approximately 18 months after the completion of the treatment. The risk factors associated with pulmonary function deterioration included smearpositive disease, extensive pulmonary involvement prior to anti-tuberculosis treatment, prolonged anti-tuberculosis treatment, and reduced radiographic improvement after treatment. CONCLUSIONS: After the completion of anti-tuberculosis TB treatment, several risk factors predicted pulmonary function deterioration. For patients with significant respiratory symptoms and multiple risk factors, the pulmonary function test should be followed up to monitor the progression of functional impairment, especially within the first 18 months after the completion of anti-tuberculosis treatment.

Original languageEnglish
Pages (from-to)549-556
Number of pages8
JournalClinics
Volume66
Issue number4
DOIs
Publication statusPublished - 2011
Externally publishedYes

Keywords

  • Completion of treatment
  • Disease extent
  • Pulmonary function
  • Pulmonary tuberculosis

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Chung, K. P., Chen, J. Y., Lee, C. H., Wu, H. D., Wang, J. Y., Lee, L. N., Yu, C. J., & Yang, P. C. (2011). Trends and predictors of changes in pulmonary function after treatment for pulmonary tuberculosis. Clinics, 66(4), 549-556. https://doi.org/10.1590/S1807-59322011000400005