Treatment Results of Oral Tongue Cancer

黃 昭源, 雷 德, 王 博民, 鍾 娜娜, 丁 禮莉(Lai-Lei Ting)

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate the therapeutic results of oral tongue cancer patients treated with curative intent at the National Taiwan University Hospital.
Materials and Methods: From 1977 to 1994, 161 oral tongue cancer patients were treated by different modalities, including surgery alone (85 patients), radiotherapy alone (40 patients) and surgery followed by radiotherapy (36 patients). Patients were grouped according to the American Joint Committee on Cancer (AJCC) staging system. Among these 161 patients, 33 (20%) were categorized as stage I; 53 (33%) stage II; 37 (23%) stage III and 38 (24%) stage IV. All of them were squamous cell carcinoma with a male to female ratio of approximately 4:1. The treatment results of primary control, neck node control, outcomes and complications were analyzed.Results: More than four fifths of the lesions were located on the lateral border of the tongue and less than 5% were either on the dorsum or undersurface. Primary control rates of Ti and T2 diseases in the OP alone group were 90% and 86%, respectively. The T3 patients of OP+REF group had better primary control rate as 67%. Primary control of T4 disease was very poor hi our three treatment groups. Even for the early disease, patients receiving surgical resection of primary tumor without further neck treatment have a higher risk (28%) of neck failure. Five-year survival rates of stage Ⅲ patients were: R/T alone, 17%; OP alone, 24%; OP+R/T, 61%. Eighty-four percent and 72% recurrence in T3/T4 and T1/T2, respectively, occurred within one year after treatment. Overall, 86% recurrence occurred within the first 2 years. Sixteen patients (10%) showed evidence of distant metastasis; most commonly presented in the lung (75%). The risk of osteonecrosis was similar between OP+R/T group (6%) and R/T alone group (3%).Conclusion: In our study, surgery can control primary tumors effectively in Ti and T2 lesions. Advanced (T3 and T4) disease is unlikely to be cured by radiation therapy or surgery alone and therefore is best managed by a planned combination of surgery and radiation therapy. For stageⅢ group, five-year survival rate was significantly improved (p<O.O5) for patients who were treated with surgery and postoperative radiotherapy. When the primary lesion is treated by simple excision, neck failure is not uncommon and adjuvant radiotherapy to the neck lymphatics may decrease its occurrence. There was 14% of recurrence occurred beyond the first 2 years which indicated that a long period of follow-up was important for tongue cancer patients.
Original languageEnglish
Pages (from-to)23-30
Number of pages8
Journal放射治療與腫瘤學
Volume4
Issue number1
DOIs
Publication statusPublished - 1997
Externally publishedYes

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Tongue Neoplasms
Mouth Neoplasms
Neck
Radiotherapy
Therapeutics
Recurrence
Survival Rate
Adjuvant Radiotherapy
Osteonecrosis
Neoplasm Staging
Taiwan
Tongue

Keywords

  • 舌癌
  • 原發與頸部腫瘤控制率
  • 併發症
  • 五年存活率
  • Oral Tongue Cancer
  • Primary and Neck Control
  • Com-Plications of Treatment
  • Five-year Survival Rate

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Treatment Results of Oral Tongue Cancer. / 黃昭源; 雷德; 王博民; 鍾娜娜; 丁禮莉(Lai-Lei Ting).

In: 放射治療與腫瘤學, Vol. 4, No. 1, 1997, p. 23-30.

Research output: Contribution to journalArticle

黃昭源 ; 雷德 ; 王博民 ; 鍾娜娜 ; 丁禮莉(Lai-Lei Ting). / Treatment Results of Oral Tongue Cancer. In: 放射治療與腫瘤學. 1997 ; Vol. 4, No. 1. pp. 23-30.
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title = "Treatment Results of Oral Tongue Cancer",
abstract = "Purpose: To evaluate the therapeutic results of oral tongue cancer patients treated with curative intent at the National Taiwan University Hospital.Materials and Methods: From 1977 to 1994, 161 oral tongue cancer patients were treated by different modalities, including surgery alone (85 patients), radiotherapy alone (40 patients) and surgery followed by radiotherapy (36 patients). Patients were grouped according to the American Joint Committee on Cancer (AJCC) staging system. Among these 161 patients, 33 (20{\%}) were categorized as stage I; 53 (33{\%}) stage II; 37 (23{\%}) stage III and 38 (24{\%}) stage IV. All of them were squamous cell carcinoma with a male to female ratio of approximately 4:1. The treatment results of primary control, neck node control, outcomes and complications were analyzed.Results: More than four fifths of the lesions were located on the lateral border of the tongue and less than 5{\%} were either on the dorsum or undersurface. Primary control rates of Ti and T2 diseases in the OP alone group were 90{\%} and 86{\%}, respectively. The T3 patients of OP+REF group had better primary control rate as 67{\%}. Primary control of T4 disease was very poor hi our three treatment groups. Even for the early disease, patients receiving surgical resection of primary tumor without further neck treatment have a higher risk (28{\%}) of neck failure. Five-year survival rates of stage Ⅲ patients were: R/T alone, 17{\%}; OP alone, 24{\%}; OP+R/T, 61{\%}. Eighty-four percent and 72{\%} recurrence in T3/T4 and T1/T2, respectively, occurred within one year after treatment. Overall, 86{\%} recurrence occurred within the first 2 years. Sixteen patients (10{\%}) showed evidence of distant metastasis; most commonly presented in the lung (75{\%}). The risk of osteonecrosis was similar between OP+R/T group (6{\%}) and R/T alone group (3{\%}).Conclusion: In our study, surgery can control primary tumors effectively in Ti and T2 lesions. Advanced (T3 and T4) disease is unlikely to be cured by radiation therapy or surgery alone and therefore is best managed by a planned combination of surgery and radiation therapy. For stageⅢ group, five-year survival rate was significantly improved (p<O.O5) for patients who were treated with surgery and postoperative radiotherapy. When the primary lesion is treated by simple excision, neck failure is not uncommon and adjuvant radiotherapy to the neck lymphatics may decrease its occurrence. There was 14{\%} of recurrence occurred beyond the first 2 years which indicated that a long period of follow-up was important for tongue cancer patients.",
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author = "昭源 黃 and 德 雷 and 博民 王 and 娜娜 鍾 and 丁, {禮莉(Lai-Lei Ting)}",
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T1 - Treatment Results of Oral Tongue Cancer

AU - 黃, 昭源

AU - 雷, 德

AU - 王, 博民

AU - 鍾, 娜娜

AU - 丁, 禮莉(Lai-Lei Ting)

PY - 1997

Y1 - 1997

N2 - Purpose: To evaluate the therapeutic results of oral tongue cancer patients treated with curative intent at the National Taiwan University Hospital.Materials and Methods: From 1977 to 1994, 161 oral tongue cancer patients were treated by different modalities, including surgery alone (85 patients), radiotherapy alone (40 patients) and surgery followed by radiotherapy (36 patients). Patients were grouped according to the American Joint Committee on Cancer (AJCC) staging system. Among these 161 patients, 33 (20%) were categorized as stage I; 53 (33%) stage II; 37 (23%) stage III and 38 (24%) stage IV. All of them were squamous cell carcinoma with a male to female ratio of approximately 4:1. The treatment results of primary control, neck node control, outcomes and complications were analyzed.Results: More than four fifths of the lesions were located on the lateral border of the tongue and less than 5% were either on the dorsum or undersurface. Primary control rates of Ti and T2 diseases in the OP alone group were 90% and 86%, respectively. The T3 patients of OP+REF group had better primary control rate as 67%. Primary control of T4 disease was very poor hi our three treatment groups. Even for the early disease, patients receiving surgical resection of primary tumor without further neck treatment have a higher risk (28%) of neck failure. Five-year survival rates of stage Ⅲ patients were: R/T alone, 17%; OP alone, 24%; OP+R/T, 61%. Eighty-four percent and 72% recurrence in T3/T4 and T1/T2, respectively, occurred within one year after treatment. Overall, 86% recurrence occurred within the first 2 years. Sixteen patients (10%) showed evidence of distant metastasis; most commonly presented in the lung (75%). The risk of osteonecrosis was similar between OP+R/T group (6%) and R/T alone group (3%).Conclusion: In our study, surgery can control primary tumors effectively in Ti and T2 lesions. Advanced (T3 and T4) disease is unlikely to be cured by radiation therapy or surgery alone and therefore is best managed by a planned combination of surgery and radiation therapy. For stageⅢ group, five-year survival rate was significantly improved (p<O.O5) for patients who were treated with surgery and postoperative radiotherapy. When the primary lesion is treated by simple excision, neck failure is not uncommon and adjuvant radiotherapy to the neck lymphatics may decrease its occurrence. There was 14% of recurrence occurred beyond the first 2 years which indicated that a long period of follow-up was important for tongue cancer patients.

AB - Purpose: To evaluate the therapeutic results of oral tongue cancer patients treated with curative intent at the National Taiwan University Hospital.Materials and Methods: From 1977 to 1994, 161 oral tongue cancer patients were treated by different modalities, including surgery alone (85 patients), radiotherapy alone (40 patients) and surgery followed by radiotherapy (36 patients). Patients were grouped according to the American Joint Committee on Cancer (AJCC) staging system. Among these 161 patients, 33 (20%) were categorized as stage I; 53 (33%) stage II; 37 (23%) stage III and 38 (24%) stage IV. All of them were squamous cell carcinoma with a male to female ratio of approximately 4:1. The treatment results of primary control, neck node control, outcomes and complications were analyzed.Results: More than four fifths of the lesions were located on the lateral border of the tongue and less than 5% were either on the dorsum or undersurface. Primary control rates of Ti and T2 diseases in the OP alone group were 90% and 86%, respectively. The T3 patients of OP+REF group had better primary control rate as 67%. Primary control of T4 disease was very poor hi our three treatment groups. Even for the early disease, patients receiving surgical resection of primary tumor without further neck treatment have a higher risk (28%) of neck failure. Five-year survival rates of stage Ⅲ patients were: R/T alone, 17%; OP alone, 24%; OP+R/T, 61%. Eighty-four percent and 72% recurrence in T3/T4 and T1/T2, respectively, occurred within one year after treatment. Overall, 86% recurrence occurred within the first 2 years. Sixteen patients (10%) showed evidence of distant metastasis; most commonly presented in the lung (75%). The risk of osteonecrosis was similar between OP+R/T group (6%) and R/T alone group (3%).Conclusion: In our study, surgery can control primary tumors effectively in Ti and T2 lesions. Advanced (T3 and T4) disease is unlikely to be cured by radiation therapy or surgery alone and therefore is best managed by a planned combination of surgery and radiation therapy. For stageⅢ group, five-year survival rate was significantly improved (p<O.O5) for patients who were treated with surgery and postoperative radiotherapy. When the primary lesion is treated by simple excision, neck failure is not uncommon and adjuvant radiotherapy to the neck lymphatics may decrease its occurrence. There was 14% of recurrence occurred beyond the first 2 years which indicated that a long period of follow-up was important for tongue cancer patients.

KW - 舌癌

KW - 原發與頸部腫瘤控制率

KW - 併發症

KW - 五年存活率

KW - Oral Tongue Cancer

KW - Primary and Neck Control

KW - Com-Plications of Treatment

KW - Five-year Survival Rate

KW - Oral tongue cancer

KW - Primary and neck control

KW - Complications of treatment

KW - Five-year survival rate

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U2 - 10.6316/TRO/199704

DO - 10.6316/TRO/199704

M3 - Article

VL - 4

SP - 23

EP - 30

JO - 放射治療與腫瘤學

JF - 放射治療與腫瘤學

SN - 1023-988x

IS - 1

ER -