Treatment Results of Malignant Lymphoma of Nasopharynx at National Taiwan University Hospital

雷 德, 許 維中, 鍾 娜娜, 王 博民, 丁 禮莉(Lai-Lei Ting), 洪 瑞隆

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate the therapeutic results of nasopharyngeal malignant lymphoma treated at NTUH over the past fifteen years (1979-1993). Materials & Methods: Forty patients with malignant lymphoma of nasopharynx visited our hospital in the past fifteen years and their data were analyzed. The age of the patients ranged from 13 to 81 years old. There were 20 male patients and 20 female patients. Stage I and LI patients were 18 and 22, respectively. According to histopathologic classification, patients with low grade, intermediate grade and high grade malignant lymphoma were 10, 26 and 4, respectively. Seven patients received radical radiotherapy and 15 patients received chemotherapy. The remaining 10 patients were treated by combined chemotherapy and irradiation. Eight patients did not receive any treatment. Results: The actuarial five-year survival rates for nasopharyngeal malignant lymphoma patients with Stage I, II were 65.7% and 27.3%, respectively. When classified by the Rappaport classification, the actuarial five-year survival rates for patients of nodular type and diffuse type were 72.7% and 33.5%, respectively. The actuarial five-year survival rates for patients of Low grade, intermediate grade and high grade nasopharyngeal malignant lymphoma were 80.0%, 39.0%, and 50.0%, respectively. The actuarial five- year survival rates for patients treated with radiotherapy, chemotherapy and combined treatment modalities were 100.0%, 58.7%, and 30.0%, respectively.Conclusion: Lymphoma clinically localized to nasopharynx can be cured by radiotherapy. When classified by histopathology, patients with low grade or nodular type can be successfully treated using local radiotherapy alone. Chemotherapy used as primary treatment (with or without adjuvant radiotherapy) may be benefit for intermediate grade or diffuse type patients.
Original languageEnglish
Pages (from-to)85-91
Number of pages7
Journal放射治療與腫瘤學
Volume4
Issue number2
DOIs
Publication statusPublished - 1997
Externally publishedYes

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Nasopharynx
Taiwan
Lymphoma
Therapeutics
Radiotherapy
Survival Rate
Drug Therapy
Adjuvant Radiotherapy

Keywords

  • 鼻咽
  • 淋巴瘤
  • 腫瘤
  • 放射治療
  • 五年存活率
  • Nasopharynx
  • Lymphoma
  • Neoplasm
  • Radiotherapy
  • Five-year survival rate

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Treatment Results of Malignant Lymphoma of Nasopharynx at National Taiwan University Hospital. / 雷德; 許維中; 鍾娜娜; 王博民; 丁禮莉(Lai-Lei Ting); 洪瑞隆.

In: 放射治療與腫瘤學, Vol. 4, No. 2, 1997, p. 85-91.

Research output: Contribution to journalArticle

雷德 ; 許維中 ; 鍾娜娜 ; 王博民 ; 丁禮莉(Lai-Lei Ting) ; 洪瑞隆. / Treatment Results of Malignant Lymphoma of Nasopharynx at National Taiwan University Hospital. In: 放射治療與腫瘤學. 1997 ; Vol. 4, No. 2. pp. 85-91.
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title = "Treatment Results of Malignant Lymphoma of Nasopharynx at National Taiwan University Hospital",
abstract = "Purpose: To evaluate the therapeutic results of nasopharyngeal malignant lymphoma treated at NTUH over the past fifteen years (1979-1993). Materials & Methods: Forty patients with malignant lymphoma of nasopharynx visited our hospital in the past fifteen years and their data were analyzed. The age of the patients ranged from 13 to 81 years old. There were 20 male patients and 20 female patients. Stage I and LI patients were 18 and 22, respectively. According to histopathologic classification, patients with low grade, intermediate grade and high grade malignant lymphoma were 10, 26 and 4, respectively. Seven patients received radical radiotherapy and 15 patients received chemotherapy. The remaining 10 patients were treated by combined chemotherapy and irradiation. Eight patients did not receive any treatment. Results: The actuarial five-year survival rates for nasopharyngeal malignant lymphoma patients with Stage I, II were 65.7{\%} and 27.3{\%}, respectively. When classified by the Rappaport classification, the actuarial five-year survival rates for patients of nodular type and diffuse type were 72.7{\%} and 33.5{\%}, respectively. The actuarial five-year survival rates for patients of Low grade, intermediate grade and high grade nasopharyngeal malignant lymphoma were 80.0{\%}, 39.0{\%}, and 50.0{\%}, respectively. The actuarial five- year survival rates for patients treated with radiotherapy, chemotherapy and combined treatment modalities were 100.0{\%}, 58.7{\%}, and 30.0{\%}, respectively.Conclusion: Lymphoma clinically localized to nasopharynx can be cured by radiotherapy. When classified by histopathology, patients with low grade or nodular type can be successfully treated using local radiotherapy alone. Chemotherapy used as primary treatment (with or without adjuvant radiotherapy) may be benefit for intermediate grade or diffuse type patients.",
keywords = "鼻咽, 淋巴瘤, 腫瘤, 放射治療, 五年存活率, Nasopharynx, Lymphoma, Neoplasm, Radiotherapy, Five-year survival rate, Nasopharynx, Lymphoma, neoplasm, Radiotherapy, Five-year survival rate",
author = "德 雷 and 維中 許 and 娜娜 鍾 and 博民 王 and 丁, {禮莉(Lai-Lei Ting)} and 瑞隆 洪",
year = "1997",
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T1 - Treatment Results of Malignant Lymphoma of Nasopharynx at National Taiwan University Hospital

AU - 雷, 德

AU - 許, 維中

AU - 鍾, 娜娜

AU - 王, 博民

AU - 丁, 禮莉(Lai-Lei Ting)

AU - 洪, 瑞隆

PY - 1997

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N2 - Purpose: To evaluate the therapeutic results of nasopharyngeal malignant lymphoma treated at NTUH over the past fifteen years (1979-1993). Materials & Methods: Forty patients with malignant lymphoma of nasopharynx visited our hospital in the past fifteen years and their data were analyzed. The age of the patients ranged from 13 to 81 years old. There were 20 male patients and 20 female patients. Stage I and LI patients were 18 and 22, respectively. According to histopathologic classification, patients with low grade, intermediate grade and high grade malignant lymphoma were 10, 26 and 4, respectively. Seven patients received radical radiotherapy and 15 patients received chemotherapy. The remaining 10 patients were treated by combined chemotherapy and irradiation. Eight patients did not receive any treatment. Results: The actuarial five-year survival rates for nasopharyngeal malignant lymphoma patients with Stage I, II were 65.7% and 27.3%, respectively. When classified by the Rappaport classification, the actuarial five-year survival rates for patients of nodular type and diffuse type were 72.7% and 33.5%, respectively. The actuarial five-year survival rates for patients of Low grade, intermediate grade and high grade nasopharyngeal malignant lymphoma were 80.0%, 39.0%, and 50.0%, respectively. The actuarial five- year survival rates for patients treated with radiotherapy, chemotherapy and combined treatment modalities were 100.0%, 58.7%, and 30.0%, respectively.Conclusion: Lymphoma clinically localized to nasopharynx can be cured by radiotherapy. When classified by histopathology, patients with low grade or nodular type can be successfully treated using local radiotherapy alone. Chemotherapy used as primary treatment (with or without adjuvant radiotherapy) may be benefit for intermediate grade or diffuse type patients.

AB - Purpose: To evaluate the therapeutic results of nasopharyngeal malignant lymphoma treated at NTUH over the past fifteen years (1979-1993). Materials & Methods: Forty patients with malignant lymphoma of nasopharynx visited our hospital in the past fifteen years and their data were analyzed. The age of the patients ranged from 13 to 81 years old. There were 20 male patients and 20 female patients. Stage I and LI patients were 18 and 22, respectively. According to histopathologic classification, patients with low grade, intermediate grade and high grade malignant lymphoma were 10, 26 and 4, respectively. Seven patients received radical radiotherapy and 15 patients received chemotherapy. The remaining 10 patients were treated by combined chemotherapy and irradiation. Eight patients did not receive any treatment. Results: The actuarial five-year survival rates for nasopharyngeal malignant lymphoma patients with Stage I, II were 65.7% and 27.3%, respectively. When classified by the Rappaport classification, the actuarial five-year survival rates for patients of nodular type and diffuse type were 72.7% and 33.5%, respectively. The actuarial five-year survival rates for patients of Low grade, intermediate grade and high grade nasopharyngeal malignant lymphoma were 80.0%, 39.0%, and 50.0%, respectively. The actuarial five- year survival rates for patients treated with radiotherapy, chemotherapy and combined treatment modalities were 100.0%, 58.7%, and 30.0%, respectively.Conclusion: Lymphoma clinically localized to nasopharynx can be cured by radiotherapy. When classified by histopathology, patients with low grade or nodular type can be successfully treated using local radiotherapy alone. Chemotherapy used as primary treatment (with or without adjuvant radiotherapy) may be benefit for intermediate grade or diffuse type patients.

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KW - 淋巴瘤

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KW - 五年存活率

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KW - Lymphoma

KW - Neoplasm

KW - Radiotherapy

KW - Five-year survival rate

KW - Nasopharynx

KW - Lymphoma

KW - neoplasm

KW - Radiotherapy

KW - Five-year survival rate

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