Treatment Results of Hodgkin's Disease from 1977 to 1991 in National Taiwan University Hospital

雷 德, 許 智捷, 鍾 娜娜, 王 博民, 黃 昭源, 丁 禮莉(Lai-Lei Ting)

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate the response and outcome of patients of Hodgkin's disease undergoing different treatment modalities. Materials and Methods: We reviewed clinical records of Hodgkin's disease who received chemotherapy (C/T), radiotherapy (R/T) or combined chemotherapy and radiotherapy (CRT) from 1977 to 1991 in National Taiwan University Hospital ( NTUH). The 5-year survival rate (SR) and 5-year freedom from relapse rate (FFR) in different stages were calculated and classified by different treatment modalities. Result: The overall 5-year survival rate (SR) and 5-year freedom from relapse rate (FFR) were summarized for stage I+Ⅱ, Ⅲ and IV diseases. In stage I+Ⅱ diseases, the SR of CIT, RIT and CRT groups were 50%, 60% and 89%; the FFR were 33%, 100% and 67% respectively. In stage Ⅲdisease, the SR of C/T and CRT groups were 72% and 90%; the FFR were 59% and 90% respectively. In stage IV disease, the SR of C/T and CRT groups were 45% and 38%; the FFR both were 38%. No statistical significance of SR was noted between CT, R/T and CRT groups in different stages. However, the FFR between C/T and R/T groups in the early stage showed statistical significance (p<O.OS). Patients with histologic subtype of lymphocyte depletion had the worst prognosis than the other 3 histologic subtypes. C/T and CRT groups bad some complications while no complication was seen in the HIT group within the 5-year follow-up. Conclusion: In our study, Hodgkin's disease was potentially curable by using either C/T, R/T, or CRT. For stage Ⅲand IV diseases, no statistical significance was noted by C/T or CRT groups. However, for early stage disease, R/T is a better treatment of choice because R/T group had better FFR and no late complication.
Original languageEnglish
Pages (from-to)31-38
Number of pages8
Journal放射治療與腫瘤學
Volume4
Issue number1
DOIs
Publication statusPublished - 1997
Externally publishedYes

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Hodgkin Disease
Taiwan
Drug Therapy
Radiotherapy
Survival Rate
Recurrence
Therapeutics
Lymphocyte Depletion

Keywords

  • 何杰金氏病
  • 化學治療
  • 放射治療
  • 合併化學與放射治療
  • 存活率
  • 免於復發率
  • Hodgkin's disease
  • Chemotherapy
  • Radiotherapy
  • Combined chemotherapy and radiotherapy
  • Survival rate
  • Freedom from relapse

Cite this

Treatment Results of Hodgkin's Disease from 1977 to 1991 in National Taiwan University Hospital. / 雷德; 許智捷; 鍾娜娜; 王博民; 黃昭源; 丁禮莉(Lai-Lei Ting).

In: 放射治療與腫瘤學, Vol. 4, No. 1, 1997, p. 31-38.

Research output: Contribution to journalArticle

雷德 ; 許智捷 ; 鍾娜娜 ; 王博民 ; 黃昭源 ; 丁禮莉(Lai-Lei Ting). / Treatment Results of Hodgkin's Disease from 1977 to 1991 in National Taiwan University Hospital. In: 放射治療與腫瘤學. 1997 ; Vol. 4, No. 1. pp. 31-38.
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AU - 許, 智捷

AU - 鍾, 娜娜

AU - 王, 博民

AU - 黃, 昭源

AU - 丁, 禮莉(Lai-Lei Ting)

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N2 - Purpose: To evaluate the response and outcome of patients of Hodgkin's disease undergoing different treatment modalities. Materials and Methods: We reviewed clinical records of Hodgkin's disease who received chemotherapy (C/T), radiotherapy (R/T) or combined chemotherapy and radiotherapy (CRT) from 1977 to 1991 in National Taiwan University Hospital ( NTUH). The 5-year survival rate (SR) and 5-year freedom from relapse rate (FFR) in different stages were calculated and classified by different treatment modalities. Result: The overall 5-year survival rate (SR) and 5-year freedom from relapse rate (FFR) were summarized for stage I+Ⅱ, Ⅲ and IV diseases. In stage I+Ⅱ diseases, the SR of CIT, RIT and CRT groups were 50%, 60% and 89%; the FFR were 33%, 100% and 67% respectively. In stage Ⅲdisease, the SR of C/T and CRT groups were 72% and 90%; the FFR were 59% and 90% respectively. In stage IV disease, the SR of C/T and CRT groups were 45% and 38%; the FFR both were 38%. No statistical significance of SR was noted between CT, R/T and CRT groups in different stages. However, the FFR between C/T and R/T groups in the early stage showed statistical significance (p<O.OS). Patients with histologic subtype of lymphocyte depletion had the worst prognosis than the other 3 histologic subtypes. C/T and CRT groups bad some complications while no complication was seen in the HIT group within the 5-year follow-up. Conclusion: In our study, Hodgkin's disease was potentially curable by using either C/T, R/T, or CRT. For stage Ⅲand IV diseases, no statistical significance was noted by C/T or CRT groups. However, for early stage disease, R/T is a better treatment of choice because R/T group had better FFR and no late complication.

AB - Purpose: To evaluate the response and outcome of patients of Hodgkin's disease undergoing different treatment modalities. Materials and Methods: We reviewed clinical records of Hodgkin's disease who received chemotherapy (C/T), radiotherapy (R/T) or combined chemotherapy and radiotherapy (CRT) from 1977 to 1991 in National Taiwan University Hospital ( NTUH). The 5-year survival rate (SR) and 5-year freedom from relapse rate (FFR) in different stages were calculated and classified by different treatment modalities. Result: The overall 5-year survival rate (SR) and 5-year freedom from relapse rate (FFR) were summarized for stage I+Ⅱ, Ⅲ and IV diseases. In stage I+Ⅱ diseases, the SR of CIT, RIT and CRT groups were 50%, 60% and 89%; the FFR were 33%, 100% and 67% respectively. In stage Ⅲdisease, the SR of C/T and CRT groups were 72% and 90%; the FFR were 59% and 90% respectively. In stage IV disease, the SR of C/T and CRT groups were 45% and 38%; the FFR both were 38%. No statistical significance of SR was noted between CT, R/T and CRT groups in different stages. However, the FFR between C/T and R/T groups in the early stage showed statistical significance (p<O.OS). Patients with histologic subtype of lymphocyte depletion had the worst prognosis than the other 3 histologic subtypes. C/T and CRT groups bad some complications while no complication was seen in the HIT group within the 5-year follow-up. Conclusion: In our study, Hodgkin's disease was potentially curable by using either C/T, R/T, or CRT. For stage Ⅲand IV diseases, no statistical significance was noted by C/T or CRT groups. However, for early stage disease, R/T is a better treatment of choice because R/T group had better FFR and no late complication.

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KW - 放射治療

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KW - 存活率

KW - 免於復發率

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KW - Radiotherapy

KW - Combined chemotherapy and radiotherapy

KW - Survival rate

KW - Freedom from relapse

KW - Hodgkin's disease

KW - Chemotherapy

KW - Radiotherapy

KW - Combined chemotherapy and radiotherapy

KW - Survival Rate

KW - Freedom form relapse

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