Treatment outcomes for multidrug-resistant tuberculosis in Eastern Taiwan

Chih Bin Lin, Hung Chieh Sun, Chen Yuan Chiang, Che Wei Wu, Hsu Wen Chou, Tao Qian Tang, Jen Jyh Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: The objective of this study is to evaluate the treatment outcomes of patients with multidrug-resistant tuberculosis (MDR-TB) under special programmatic management in Eastern Taiwan over the past 10 years. Materials and Methods: All newly diagnosed MDR-TB patients and MDR-TB patients enrolled previously with persistent positive cultures were included in this study, from May 2007 to April 2017, in Eastern Taiwan. A panel of pulmonologists designed the initial MDR-TB regimens. Subsequently, regimens were adjusted according to drug susceptibility test results for second-line drugs. Mobile teams were organized for treatment support, and several measures were adapted to safeguard effective treatment support. Results: A total of 178 patients with bacteriological confirmed pulmonary MDR-TB were identified, of whom 167 had treatment outcomes when the study was conducted. Of these 167 patients, 120 (71.9%) were cured, 11 (6.5%) completed therapy (78.4% had successful treatment), 25 (15.0%) died, 9 (5.4%) had treatment failure, none were transferred out, and 2 (1.2%) were lost to follow-up. Surgery was performed on 8 (4.8%). Conclusions: This is an analysis of the treatment outcomes after adopting the Directly Observed Treatment, Short-course Plus program to treat MDR-TB patients in Eastern Taiwan. We had a low proportion of loss-to-follow-up, resulting in a high treatment success rate. This program serves as an effective model in providing quality care to patients with MDR-TB.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalTzu Chi Medical Journal
Volume31
Issue number1
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Multidrug-Resistant Tuberculosis
Taiwan
Therapeutics
Quality of Health Care
Lost to Follow-Up
Treatment Failure
Pulmonary Tuberculosis
Pharmaceutical Preparations
Outcome Assessment (Health Care)

Keywords

  • Directly observed treatment
  • Eastern Taiwan
  • Multidrug-resistant tuberculosis
  • Short-course Plus program
  • Treatment outcomes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lin, C. B., Sun, H. C., Chiang, C. Y., Wu, C. W., Chou, H. W., Tang, T. Q., & Lee, J. J. (2019). Treatment outcomes for multidrug-resistant tuberculosis in Eastern Taiwan. Tzu Chi Medical Journal, 31(1), 35-39. https://doi.org/10.4103/tcmj.tcmj_18_18

Treatment outcomes for multidrug-resistant tuberculosis in Eastern Taiwan. / Lin, Chih Bin; Sun, Hung Chieh; Chiang, Chen Yuan; Wu, Che Wei; Chou, Hsu Wen; Tang, Tao Qian; Lee, Jen Jyh.

In: Tzu Chi Medical Journal, Vol. 31, No. 1, 01.01.2019, p. 35-39.

Research output: Contribution to journalArticle

Lin, Chih Bin ; Sun, Hung Chieh ; Chiang, Chen Yuan ; Wu, Che Wei ; Chou, Hsu Wen ; Tang, Tao Qian ; Lee, Jen Jyh. / Treatment outcomes for multidrug-resistant tuberculosis in Eastern Taiwan. In: Tzu Chi Medical Journal. 2019 ; Vol. 31, No. 1. pp. 35-39.
@article{06c918a07a5c49f89e818828faad51b7,
title = "Treatment outcomes for multidrug-resistant tuberculosis in Eastern Taiwan",
abstract = "Objectives: The objective of this study is to evaluate the treatment outcomes of patients with multidrug-resistant tuberculosis (MDR-TB) under special programmatic management in Eastern Taiwan over the past 10 years. Materials and Methods: All newly diagnosed MDR-TB patients and MDR-TB patients enrolled previously with persistent positive cultures were included in this study, from May 2007 to April 2017, in Eastern Taiwan. A panel of pulmonologists designed the initial MDR-TB regimens. Subsequently, regimens were adjusted according to drug susceptibility test results for second-line drugs. Mobile teams were organized for treatment support, and several measures were adapted to safeguard effective treatment support. Results: A total of 178 patients with bacteriological confirmed pulmonary MDR-TB were identified, of whom 167 had treatment outcomes when the study was conducted. Of these 167 patients, 120 (71.9{\%}) were cured, 11 (6.5{\%}) completed therapy (78.4{\%} had successful treatment), 25 (15.0{\%}) died, 9 (5.4{\%}) had treatment failure, none were transferred out, and 2 (1.2{\%}) were lost to follow-up. Surgery was performed on 8 (4.8{\%}). Conclusions: This is an analysis of the treatment outcomes after adopting the Directly Observed Treatment, Short-course Plus program to treat MDR-TB patients in Eastern Taiwan. We had a low proportion of loss-to-follow-up, resulting in a high treatment success rate. This program serves as an effective model in providing quality care to patients with MDR-TB.",
keywords = "Directly observed treatment, Eastern Taiwan, Multidrug-resistant tuberculosis, Short-course Plus program, Treatment outcomes",
author = "Lin, {Chih Bin} and Sun, {Hung Chieh} and Chiang, {Chen Yuan} and Wu, {Che Wei} and Chou, {Hsu Wen} and Tang, {Tao Qian} and Lee, {Jen Jyh}",
year = "2019",
month = "1",
day = "1",
doi = "10.4103/tcmj.tcmj_18_18",
language = "English",
volume = "31",
pages = "35--39",
journal = "Tzu Chi Medical Journal",
issn = "1016-3190",
publisher = "財團法人中華民國佛教慈濟慈善事業基金會",
number = "1",

}

TY - JOUR

T1 - Treatment outcomes for multidrug-resistant tuberculosis in Eastern Taiwan

AU - Lin, Chih Bin

AU - Sun, Hung Chieh

AU - Chiang, Chen Yuan

AU - Wu, Che Wei

AU - Chou, Hsu Wen

AU - Tang, Tao Qian

AU - Lee, Jen Jyh

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objectives: The objective of this study is to evaluate the treatment outcomes of patients with multidrug-resistant tuberculosis (MDR-TB) under special programmatic management in Eastern Taiwan over the past 10 years. Materials and Methods: All newly diagnosed MDR-TB patients and MDR-TB patients enrolled previously with persistent positive cultures were included in this study, from May 2007 to April 2017, in Eastern Taiwan. A panel of pulmonologists designed the initial MDR-TB regimens. Subsequently, regimens were adjusted according to drug susceptibility test results for second-line drugs. Mobile teams were organized for treatment support, and several measures were adapted to safeguard effective treatment support. Results: A total of 178 patients with bacteriological confirmed pulmonary MDR-TB were identified, of whom 167 had treatment outcomes when the study was conducted. Of these 167 patients, 120 (71.9%) were cured, 11 (6.5%) completed therapy (78.4% had successful treatment), 25 (15.0%) died, 9 (5.4%) had treatment failure, none were transferred out, and 2 (1.2%) were lost to follow-up. Surgery was performed on 8 (4.8%). Conclusions: This is an analysis of the treatment outcomes after adopting the Directly Observed Treatment, Short-course Plus program to treat MDR-TB patients in Eastern Taiwan. We had a low proportion of loss-to-follow-up, resulting in a high treatment success rate. This program serves as an effective model in providing quality care to patients with MDR-TB.

AB - Objectives: The objective of this study is to evaluate the treatment outcomes of patients with multidrug-resistant tuberculosis (MDR-TB) under special programmatic management in Eastern Taiwan over the past 10 years. Materials and Methods: All newly diagnosed MDR-TB patients and MDR-TB patients enrolled previously with persistent positive cultures were included in this study, from May 2007 to April 2017, in Eastern Taiwan. A panel of pulmonologists designed the initial MDR-TB regimens. Subsequently, regimens were adjusted according to drug susceptibility test results for second-line drugs. Mobile teams were organized for treatment support, and several measures were adapted to safeguard effective treatment support. Results: A total of 178 patients with bacteriological confirmed pulmonary MDR-TB were identified, of whom 167 had treatment outcomes when the study was conducted. Of these 167 patients, 120 (71.9%) were cured, 11 (6.5%) completed therapy (78.4% had successful treatment), 25 (15.0%) died, 9 (5.4%) had treatment failure, none were transferred out, and 2 (1.2%) were lost to follow-up. Surgery was performed on 8 (4.8%). Conclusions: This is an analysis of the treatment outcomes after adopting the Directly Observed Treatment, Short-course Plus program to treat MDR-TB patients in Eastern Taiwan. We had a low proportion of loss-to-follow-up, resulting in a high treatment success rate. This program serves as an effective model in providing quality care to patients with MDR-TB.

KW - Directly observed treatment

KW - Eastern Taiwan

KW - Multidrug-resistant tuberculosis

KW - Short-course Plus program

KW - Treatment outcomes

UR - http://www.scopus.com/inward/record.url?scp=85059868970&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059868970&partnerID=8YFLogxK

U2 - 10.4103/tcmj.tcmj_18_18

DO - 10.4103/tcmj.tcmj_18_18

M3 - Article

AN - SCOPUS:85059868970

VL - 31

SP - 35

EP - 39

JO - Tzu Chi Medical Journal

JF - Tzu Chi Medical Journal

SN - 1016-3190

IS - 1

ER -