Treatment outcomes for multidrug-resistant tuberculosis in Eastern Taiwan

Chih Bin Lin, Hung Chieh Sun, Chen Yuan Chiang, Che Wei Wu, Hsu Wen Chou, Tao Qian Tang, Jen Jyh Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: The objective of this study is to evaluate the treatment outcomes of patients with multidrug-resistant tuberculosis (MDR-TB) under special programmatic management in Eastern Taiwan over the past 10 years. Materials and Methods: All newly diagnosed MDR-TB patients and MDR-TB patients enrolled previously with persistent positive cultures were included in this study, from May 2007 to April 2017, in Eastern Taiwan. A panel of pulmonologists designed the initial MDR-TB regimens. Subsequently, regimens were adjusted according to drug susceptibility test results for second-line drugs. Mobile teams were organized for treatment support, and several measures were adapted to safeguard effective treatment support. Results: A total of 178 patients with bacteriological confirmed pulmonary MDR-TB were identified, of whom 167 had treatment outcomes when the study was conducted. Of these 167 patients, 120 (71.9%) were cured, 11 (6.5%) completed therapy (78.4% had successful treatment), 25 (15.0%) died, 9 (5.4%) had treatment failure, none were transferred out, and 2 (1.2%) were lost to follow-up. Surgery was performed on 8 (4.8%). Conclusions: This is an analysis of the treatment outcomes after adopting the Directly Observed Treatment, Short-course Plus program to treat MDR-TB patients in Eastern Taiwan. We had a low proportion of loss-to-follow-up, resulting in a high treatment success rate. This program serves as an effective model in providing quality care to patients with MDR-TB.
Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalTzu Chi Medical Journal
Volume31
Issue number1
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Directly observed treatment
  • Eastern Taiwan
  • Multidrug-resistant tuberculosis
  • Short-course Plus program
  • Treatment outcomes

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Lin, C. B., Sun, H. C., Chiang, C. Y., Wu, C. W., Chou, H. W., Tang, T. Q., & Lee, J. J. (2019). Treatment outcomes for multidrug-resistant tuberculosis in Eastern Taiwan. Tzu Chi Medical Journal, 31(1), 35-39. https://doi.org/10.4103/tcmj.tcmj_18_18