鼻腔NK/T細胞淋巴瘤三度空間立體順形放射治療成果:臺灣單一機構研究: Treatment Outcome following Three-dimensional Conformal Radiation Therapy (3D-CRT) for NK/T-cell Lymphoma of Nasal Cavity: A Single Institute Survey in Taiwan.

Translated title of the contribution: Treatment Outcome following Three-dimensional Conformal Radiation Therapy (3D-CRT) for NK/T-cell Lymphoma of Nasal Cavity: A Single Institute Survey in Taiwan.

Szu-Yuan Wu, 方 富民(Fu-Min Fang), 郭 景元(Ching-Yuan Kuo), 王 重榮(Chong-Jong Wang), 陳 惠君(Hui-Chun Chen), 許 軒之(Hsuan-Chih Hsu), 黃 郁傑(Yu-Jie Huang), 汪 昶佑(Chang-Yu Wang), 黃 英彥(Eng-Yen Huang)

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate the treatment outcome following three-dimensional conformal radiotherapy (3D-CRT) for NK/T-cell lymphoma of nasal cavity.
Materials and Methods: Between August 2000 and March 2005, 11 patients had NK/T-cell lymphomas of nasal cavity diagnosed by histopathologic characteristics and typical immunophenotype. There were 5 males and 6 females, patients with age ranged from 27 years to 90 years (median, 57 years). Five patients were scheduled to receive 4-6 cycles of CHOP (cyclophosphamide, doxorubicin, vincrinstine and prednisolone) followed by radiotherapy. Three patients received 3 cycles of neo-adjuvant CHOP, radiotherapy, and 3 cycles of CHOP adjuvant. We excluded two patients who were dead during our radiotherapy course. All patients received 3D-CRT. The planned 3D-CRT dose was 50.4-54.0 Gy / 28-30 fractions.
Results: The median time of follow-up was 24.9 months (range 4 to 75 months). Seven (78%) of nine patients achieved complete remission (CR). The 2-year overall survival (OS) rate was 79%. Two patients expired in the first year. The 2-year local control and distant metastasis-free rates were 89% and 79%, respectively. The clinical factors predicting worse survival in univariate analysis were as follows: advanced Ann Arbor stage (p=0.005), B symptom (p=0.005), and higher International Prognostic Index scores (p=0.005). In the stage IE group, 7 of 8 patients (88%) achieved CR. The 2-year OS rate was 88%. The side effects of 3D-CRT were temporary and acceptable.
Conclusion: In our experience, the treatment policy for NK/T cell lymphoma of nasal cavity using 3D-CRT with greater than 50 Gy to gross tumor/tumor bed plus adequate margin was feasible.
Translated title of the contributionTreatment Outcome following Three-dimensional Conformal Radiation Therapy (3D-CRT) for NK/T-cell Lymphoma of Nasal Cavity: A Single Institute Survey in Taiwan.
Original languageUndefined/Unknown
Pages (from-to)165-178
Number of pages14
Journal放射治療與腫瘤學
Volume14
Issue number3
DOIs
Publication statusPublished - 2007
Externally publishedYes

Keywords

  • Three-dimensional conformal radiotherapy
  • NK/T-cell lymphoma
  • Nasal cavity
  • Overall survival

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