Treatment of thrombotic microangiopathy in pregnancy with exchange

A report of two cases

Mei Jou Chen, Hwei Fang Tien, Hong Nerng Ho

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Thrombotic microangiopathy is a rare disease that can be induced and precipitated by pregnancy, and is associated with high maternal and fetal morbidity and mortality. It results from abnormal intravascular platelet aggregation that leads to transient ischemia in various organs, including the central nervous system, kidneys and placenta. Plasma exchange is the most widely accepted method of treatment for this condition. Delayed diagnosis is the main reason for morbidity and mortality, and results from difficulty in differentiating thrombotic microangiopathy from other obstetric emergencies. We report two cases of thrombotic microangiopathy that occurred antepartum and postpartum, respectively. The first patient was a 33-year-old woman who had two previous episodes of intrauterine fetal death in the 13th and 28th weeks of gestation, respectively. She received early plasma exchange at the 23rd week of gestation during this pregnancy and the fetus was delivered uneventfully. The second patient was a 28-year-old woman with progressive thrombocytopenia, anemia and deterioration of renal and liver function postpartum. She received early plasma exchange and it markedly improved her thrombocytopenia without sequelae. In conclusion, early diagnosis and early initiation of plasmapheresis may improve both maternal and fetal prognosis in thrombotic microangiopathy.

Original languageEnglish
Pages (from-to)859-863
Number of pages5
JournalJournal of the Formosan Medical Association
Volume101
Issue number12
Publication statusPublished - Dec 1 2002
Externally publishedYes

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Hematologic Pregnancy Complications
Thrombotic Microangiopathies
Hemolytic-Uremic Syndrome
Plasma Exchange
Purpura
Pregnancy
Thrombocytopenia
Postpartum Period
Mothers
Morbidity
Kidney
Fetal Mortality
Fetal Death
Plasmapheresis
Delayed Diagnosis
Therapeutics
Rare Diseases
Platelet Aggregation
Placenta
Obstetrics

Keywords

  • Hemolytic uremic syndrome
  • Plasma exchange
  • Pregnancy
  • Purpura
  • Thrombotic microangiopathy
  • Thrombotic thrombocytopenic

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Treatment of thrombotic microangiopathy in pregnancy with exchange : A report of two cases. / Chen, Mei Jou; Tien, Hwei Fang; Ho, Hong Nerng.

In: Journal of the Formosan Medical Association, Vol. 101, No. 12, 01.12.2002, p. 859-863.

Research output: Contribution to journalArticle

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