Treatment of spinal cord ependymomas by surgery with or without postoperative radiotherapy

Yi Hsien Lin, Chun I. Huang, Tai-Tong Wong, Min Hsiung Chen, Cheng Ying Shiau, Ling Wei Wang, Donald Ming Tak Ho, Sang Hue Yen

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Purpose: To evaluate the effectiveness of complete resection and postoperative radiotherapy in spinal cord ependymomas. Methods and materials: We conducted a retrospective study over 20 patients (13 males and 7 females) with histologically confirmed spinal cord ependymomas between July 1985 and April 2001. Among them, 13 patients had ependymomas, 6 had myxopapillary ependymomas, and 1 had anaplastic ependymoma. All patients received radical surgery for tumor removal with 13 patients achieving complete resection and 7 incomplete resection due to technical difficulty. Among those with incomplete resection, 6 patients received postoperative radiotherapy to tumor bed and only one patient with anaplastic ependymoma received surgery alone. The total tumor dose ranged from 50 to 60 Gy. Results: Among the 20 patients, 19 patients were alive and showed local control. The median survival time of all patients was 109 months, with 104 months in the complete resection alone group and 135 months in the incomplete resection with postoperative radiotherapy group. One patient with anaplastic ependymoma and no postoperative radiotherapy developed leptomeningeal seeding 9 months after surgery. Salvage therapy of radiotherapy and chemotherapy maintained normal neurological functions. The patient expired 34 months from the initial diagnosis due to progression of leptomeningeal seeding. Conclusion: Complete resection alone in spinal cord ependymoma can achieve excellent local control and survival. Patients should receive complete resection if technically possible. Postoperative radiotherapy is not recommended for complete resection. For incomplete resection, postoperative local radiotherapy is recommended and it can also achieve excellent local control and survival. Local radiotherapy with 50-60 Gy is effective and safe. Salvage radiotherapy improves quality of life for local recurrence or leptomeningeal seeding patients.

Original languageEnglish
Pages (from-to)205-210
Number of pages6
JournalJournal of Neuro-Oncology
Volume71
Issue number2
DOIs
Publication statusPublished - Jan 1 2005
Externally publishedYes

Fingerprint

Ependymoma
Spinal Cord
Radiotherapy
Therapeutics
Survival
Salvage Therapy
Neoplasms

Keywords

  • Ependymoma
  • Myxopapillary ependymoma
  • Postoperative radiotherapy
  • Spinalcord
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Cite this

Treatment of spinal cord ependymomas by surgery with or without postoperative radiotherapy. / Lin, Yi Hsien; Huang, Chun I.; Wong, Tai-Tong; Chen, Min Hsiung; Shiau, Cheng Ying; Wang, Ling Wei; Ho, Donald Ming Tak; Yen, Sang Hue.

In: Journal of Neuro-Oncology, Vol. 71, No. 2, 01.01.2005, p. 205-210.

Research output: Contribution to journalArticle

Lin, Yi Hsien ; Huang, Chun I. ; Wong, Tai-Tong ; Chen, Min Hsiung ; Shiau, Cheng Ying ; Wang, Ling Wei ; Ho, Donald Ming Tak ; Yen, Sang Hue. / Treatment of spinal cord ependymomas by surgery with or without postoperative radiotherapy. In: Journal of Neuro-Oncology. 2005 ; Vol. 71, No. 2. pp. 205-210.
@article{6f36aa0f2fbc44738af5f47730c5d693,
title = "Treatment of spinal cord ependymomas by surgery with or without postoperative radiotherapy",
abstract = "Purpose: To evaluate the effectiveness of complete resection and postoperative radiotherapy in spinal cord ependymomas. Methods and materials: We conducted a retrospective study over 20 patients (13 males and 7 females) with histologically confirmed spinal cord ependymomas between July 1985 and April 2001. Among them, 13 patients had ependymomas, 6 had myxopapillary ependymomas, and 1 had anaplastic ependymoma. All patients received radical surgery for tumor removal with 13 patients achieving complete resection and 7 incomplete resection due to technical difficulty. Among those with incomplete resection, 6 patients received postoperative radiotherapy to tumor bed and only one patient with anaplastic ependymoma received surgery alone. The total tumor dose ranged from 50 to 60 Gy. Results: Among the 20 patients, 19 patients were alive and showed local control. The median survival time of all patients was 109 months, with 104 months in the complete resection alone group and 135 months in the incomplete resection with postoperative radiotherapy group. One patient with anaplastic ependymoma and no postoperative radiotherapy developed leptomeningeal seeding 9 months after surgery. Salvage therapy of radiotherapy and chemotherapy maintained normal neurological functions. The patient expired 34 months from the initial diagnosis due to progression of leptomeningeal seeding. Conclusion: Complete resection alone in spinal cord ependymoma can achieve excellent local control and survival. Patients should receive complete resection if technically possible. Postoperative radiotherapy is not recommended for complete resection. For incomplete resection, postoperative local radiotherapy is recommended and it can also achieve excellent local control and survival. Local radiotherapy with 50-60 Gy is effective and safe. Salvage radiotherapy improves quality of life for local recurrence or leptomeningeal seeding patients.",
keywords = "Ependymoma, Myxopapillary ependymoma, Postoperative radiotherapy, Spinalcord, Surgery",
author = "Lin, {Yi Hsien} and Huang, {Chun I.} and Tai-Tong Wong and Chen, {Min Hsiung} and Shiau, {Cheng Ying} and Wang, {Ling Wei} and Ho, {Donald Ming Tak} and Yen, {Sang Hue}",
year = "2005",
month = "1",
day = "1",
doi = "10.1007/s11060-004-1386-y",
language = "English",
volume = "71",
pages = "205--210",
journal = "Journal of Neuro-Oncology",
issn = "0167-594X",
publisher = "Kluwer Academic Publishers",
number = "2",

}

TY - JOUR

T1 - Treatment of spinal cord ependymomas by surgery with or without postoperative radiotherapy

AU - Lin, Yi Hsien

AU - Huang, Chun I.

AU - Wong, Tai-Tong

AU - Chen, Min Hsiung

AU - Shiau, Cheng Ying

AU - Wang, Ling Wei

AU - Ho, Donald Ming Tak

AU - Yen, Sang Hue

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Purpose: To evaluate the effectiveness of complete resection and postoperative radiotherapy in spinal cord ependymomas. Methods and materials: We conducted a retrospective study over 20 patients (13 males and 7 females) with histologically confirmed spinal cord ependymomas between July 1985 and April 2001. Among them, 13 patients had ependymomas, 6 had myxopapillary ependymomas, and 1 had anaplastic ependymoma. All patients received radical surgery for tumor removal with 13 patients achieving complete resection and 7 incomplete resection due to technical difficulty. Among those with incomplete resection, 6 patients received postoperative radiotherapy to tumor bed and only one patient with anaplastic ependymoma received surgery alone. The total tumor dose ranged from 50 to 60 Gy. Results: Among the 20 patients, 19 patients were alive and showed local control. The median survival time of all patients was 109 months, with 104 months in the complete resection alone group and 135 months in the incomplete resection with postoperative radiotherapy group. One patient with anaplastic ependymoma and no postoperative radiotherapy developed leptomeningeal seeding 9 months after surgery. Salvage therapy of radiotherapy and chemotherapy maintained normal neurological functions. The patient expired 34 months from the initial diagnosis due to progression of leptomeningeal seeding. Conclusion: Complete resection alone in spinal cord ependymoma can achieve excellent local control and survival. Patients should receive complete resection if technically possible. Postoperative radiotherapy is not recommended for complete resection. For incomplete resection, postoperative local radiotherapy is recommended and it can also achieve excellent local control and survival. Local radiotherapy with 50-60 Gy is effective and safe. Salvage radiotherapy improves quality of life for local recurrence or leptomeningeal seeding patients.

AB - Purpose: To evaluate the effectiveness of complete resection and postoperative radiotherapy in spinal cord ependymomas. Methods and materials: We conducted a retrospective study over 20 patients (13 males and 7 females) with histologically confirmed spinal cord ependymomas between July 1985 and April 2001. Among them, 13 patients had ependymomas, 6 had myxopapillary ependymomas, and 1 had anaplastic ependymoma. All patients received radical surgery for tumor removal with 13 patients achieving complete resection and 7 incomplete resection due to technical difficulty. Among those with incomplete resection, 6 patients received postoperative radiotherapy to tumor bed and only one patient with anaplastic ependymoma received surgery alone. The total tumor dose ranged from 50 to 60 Gy. Results: Among the 20 patients, 19 patients were alive and showed local control. The median survival time of all patients was 109 months, with 104 months in the complete resection alone group and 135 months in the incomplete resection with postoperative radiotherapy group. One patient with anaplastic ependymoma and no postoperative radiotherapy developed leptomeningeal seeding 9 months after surgery. Salvage therapy of radiotherapy and chemotherapy maintained normal neurological functions. The patient expired 34 months from the initial diagnosis due to progression of leptomeningeal seeding. Conclusion: Complete resection alone in spinal cord ependymoma can achieve excellent local control and survival. Patients should receive complete resection if technically possible. Postoperative radiotherapy is not recommended for complete resection. For incomplete resection, postoperative local radiotherapy is recommended and it can also achieve excellent local control and survival. Local radiotherapy with 50-60 Gy is effective and safe. Salvage radiotherapy improves quality of life for local recurrence or leptomeningeal seeding patients.

KW - Ependymoma

KW - Myxopapillary ependymoma

KW - Postoperative radiotherapy

KW - Spinalcord

KW - Surgery

UR - http://www.scopus.com/inward/record.url?scp=20144369333&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20144369333&partnerID=8YFLogxK

U2 - 10.1007/s11060-004-1386-y

DO - 10.1007/s11060-004-1386-y

M3 - Article

VL - 71

SP - 205

EP - 210

JO - Journal of Neuro-Oncology

JF - Journal of Neuro-Oncology

SN - 0167-594X

IS - 2

ER -