Treatment of nonhealing diabetic lower extremity ulcers with skin graft and autologous platelet gel: A case series

Yuan Sheng Tzeng, Shou Cheng Deng, Chih Hsing Wang, Jui Che Tsai, Tim Mo Chen, Thierry Burnouf

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Lower extremity ulcers in diabetic patients are difficult to treat. Recently, the use of human blood platelet-derived components in this indication has been raising interest. In this study, we have evaluated the safety and efficacy of the combination of autologous platelet gel (PG) and skin graft for treating large size recalcitrant ulcers. Eight consecutive diabetic patients aged 25 to 82 with nine nonhealing lower extremity ulcers (median size of 50 cm2; range 15-150 cm2) were treated. Skin ulcer was debrided, and the wound was sprayed after 7 to 10 days with autologous platelet-rich plasma and thrombin. Thin split-thickness skin graft with multiple slits was then applied on the wound bed and fixed with staples or cat-gut sutures. There were no adverse reactions observed during the study. Eight out of 9 skin grafts took well. The interval between skin graft and complete wound healing ranged from 2 to 3 weeks in the 8 successful cases. No ulcer recurrence was noted in those patients during the follow-up period of 2 to 19 months. In this study, the combination of autologous platelet gel and skin grafting has proven beneficial to heal large-size recalcitrant ulcers.

Original languageEnglish
Article number837620
JournalBioMed Research International
Volume2013
DOIs
Publication statusPublished - 2013

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Skin Ulcer
Platelets
Grafts
Ulcer
Lower Extremity
Skin
Blood Platelets
Gels
Transplants
Therapeutics
Skin Transplantation
Platelet-Rich Plasma
Wounds and Injuries
Thrombin
Wound Healing
Sutures
Cats
Blood
Safety
Recurrence

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Treatment of nonhealing diabetic lower extremity ulcers with skin graft and autologous platelet gel : A case series. / Tzeng, Yuan Sheng; Deng, Shou Cheng; Wang, Chih Hsing; Tsai, Jui Che; Chen, Tim Mo; Burnouf, Thierry.

In: BioMed Research International, Vol. 2013, 837620, 2013.

Research output: Contribution to journalArticle

Tzeng, Yuan Sheng ; Deng, Shou Cheng ; Wang, Chih Hsing ; Tsai, Jui Che ; Chen, Tim Mo ; Burnouf, Thierry. / Treatment of nonhealing diabetic lower extremity ulcers with skin graft and autologous platelet gel : A case series. In: BioMed Research International. 2013 ; Vol. 2013.
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