Treatment of Hypopharyngeal Carcinoma: A Retrospective Analysis over a 16-Year Period

鍾 娜娜, 丁 禮莉(Lai-Lei Ting), 黃 淑珍, 方 麗麗, 雷 德, 李 憲彥(Shiann-Yann Lee)

Research output: Contribution to journalArticle

Abstract

This retrospective study reviewed a group of 187 hypopharyngeal cancer patients treated in National Taiwan University Hospital (NTUH) over the 16-year period from 1977 to 1992. Patients were grouped according to the American Joint Committee on Cancer (AJCC) staging system. Among the 187 patients, only 9 (5%) were categorized as early stage (I + II) the remaining 178 patients (95%) were categorized as advanced stage (III + IV). A majority of the patients (89 patients) were treated by radical radiation therapy (R/T); 54 patients, by operation followed by radiation therapy (Op + R/T) and 20 patients, by operation alone (Op). The remainder were treated with a combination of three treatment modalities (chemotherapy, operation or radiotherapy). Overall three-year and five-year survival rates were 26.9% and 19.8%, respectively. Three-year survival rates in the advanced stage patients managed by different treatment modalities were: R/T alone, 21.5%; Op, was 23.4%; Op + R/T was 30.2%. Combined Op and R/ T had a statistically improved survival rate (p<0.01). Local recurrence rate: R/T alone was 36%; Op was 60% and Op + R/T was 37%. On the basis of these results, the survival rate was increased and the local recurrence rate, decreased by combined therapy. However, treatment outcomes in hypopharyngeal cancer remain unfavorable, even with a combination of surgery and radiation therapy. Alternative approaches should be actively investigated to improve survival.
Original languageEnglish
Pages (from-to)33-42
Number of pages10
JournalChinese Journal of Radiology
Volume20
Issue number1
Publication statusPublished - 1995
Externally publishedYes

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Radiotherapy
Carcinoma
Survival Rate
Hypopharyngeal Neoplasms
Therapeutics
Recurrence
Neoplasm Staging
Taiwan
Retrospective Studies
Drug Therapy
Survival

Keywords

  • 咽部,腫瘤
  • 咽部,放射線治療
  • 放射線治療,術後
  • Pharynx, neoplasms
  • pharynx, therapeutic radiology
  • therapeutic radiology, postoperative

Cite this

鍾娜娜, 丁禮莉(Lai-Lei T, 黃淑珍, 方麗麗, 雷德, & 李憲彥(Shiann-Yann L (1995). Treatment of Hypopharyngeal Carcinoma: A Retrospective Analysis over a 16-Year Period. Chinese Journal of Radiology, 20(1), 33-42.

Treatment of Hypopharyngeal Carcinoma: A Retrospective Analysis over a 16-Year Period. / 鍾娜娜; 丁禮莉(Lai-Lei Ting); 黃淑珍; 方麗麗; 雷德; 李憲彥(Shiann-Yann Lee).

In: Chinese Journal of Radiology, Vol. 20, No. 1, 1995, p. 33-42.

Research output: Contribution to journalArticle

鍾娜娜, 丁禮莉(Lai-LeiT, 黃淑珍, 方麗麗, 雷德 & 李憲彥(Shiann-YannL 1995, 'Treatment of Hypopharyngeal Carcinoma: A Retrospective Analysis over a 16-Year Period', Chinese Journal of Radiology, vol. 20, no. 1, pp. 33-42.
鍾娜娜 ; 丁禮莉(Lai-Lei Ting) ; 黃淑珍 ; 方麗麗 ; 雷德 ; 李憲彥(Shiann-Yann Lee). / Treatment of Hypopharyngeal Carcinoma: A Retrospective Analysis over a 16-Year Period. In: Chinese Journal of Radiology. 1995 ; Vol. 20, No. 1. pp. 33-42.
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abstract = "This retrospective study reviewed a group of 187 hypopharyngeal cancer patients treated in National Taiwan University Hospital (NTUH) over the 16-year period from 1977 to 1992. Patients were grouped according to the American Joint Committee on Cancer (AJCC) staging system. Among the 187 patients, only 9 (5{\%}) were categorized as early stage (I + II) the remaining 178 patients (95{\%}) were categorized as advanced stage (III + IV). A majority of the patients (89 patients) were treated by radical radiation therapy (R/T); 54 patients, by operation followed by radiation therapy (Op + R/T) and 20 patients, by operation alone (Op). The remainder were treated with a combination of three treatment modalities (chemotherapy, operation or radiotherapy). Overall three-year and five-year survival rates were 26.9{\%} and 19.8{\%}, respectively. Three-year survival rates in the advanced stage patients managed by different treatment modalities were: R/T alone, 21.5{\%}; Op, was 23.4{\%}; Op + R/T was 30.2{\%}. Combined Op and R/ T had a statistically improved survival rate (p<0.01). Local recurrence rate: R/T alone was 36{\%}; Op was 60{\%} and Op + R/T was 37{\%}. On the basis of these results, the survival rate was increased and the local recurrence rate, decreased by combined therapy. However, treatment outcomes in hypopharyngeal cancer remain unfavorable, even with a combination of surgery and radiation therapy. Alternative approaches should be actively investigated to improve survival.",
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AU - 黃, 淑珍

AU - 方, 麗麗

AU - 雷, 德

AU - 李, 憲彥(Shiann-Yann Lee)

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N2 - This retrospective study reviewed a group of 187 hypopharyngeal cancer patients treated in National Taiwan University Hospital (NTUH) over the 16-year period from 1977 to 1992. Patients were grouped according to the American Joint Committee on Cancer (AJCC) staging system. Among the 187 patients, only 9 (5%) were categorized as early stage (I + II) the remaining 178 patients (95%) were categorized as advanced stage (III + IV). A majority of the patients (89 patients) were treated by radical radiation therapy (R/T); 54 patients, by operation followed by radiation therapy (Op + R/T) and 20 patients, by operation alone (Op). The remainder were treated with a combination of three treatment modalities (chemotherapy, operation or radiotherapy). Overall three-year and five-year survival rates were 26.9% and 19.8%, respectively. Three-year survival rates in the advanced stage patients managed by different treatment modalities were: R/T alone, 21.5%; Op, was 23.4%; Op + R/T was 30.2%. Combined Op and R/ T had a statistically improved survival rate (p<0.01). Local recurrence rate: R/T alone was 36%; Op was 60% and Op + R/T was 37%. On the basis of these results, the survival rate was increased and the local recurrence rate, decreased by combined therapy. However, treatment outcomes in hypopharyngeal cancer remain unfavorable, even with a combination of surgery and radiation therapy. Alternative approaches should be actively investigated to improve survival.

AB - This retrospective study reviewed a group of 187 hypopharyngeal cancer patients treated in National Taiwan University Hospital (NTUH) over the 16-year period from 1977 to 1992. Patients were grouped according to the American Joint Committee on Cancer (AJCC) staging system. Among the 187 patients, only 9 (5%) were categorized as early stage (I + II) the remaining 178 patients (95%) were categorized as advanced stage (III + IV). A majority of the patients (89 patients) were treated by radical radiation therapy (R/T); 54 patients, by operation followed by radiation therapy (Op + R/T) and 20 patients, by operation alone (Op). The remainder were treated with a combination of three treatment modalities (chemotherapy, operation or radiotherapy). Overall three-year and five-year survival rates were 26.9% and 19.8%, respectively. Three-year survival rates in the advanced stage patients managed by different treatment modalities were: R/T alone, 21.5%; Op, was 23.4%; Op + R/T was 30.2%. Combined Op and R/ T had a statistically improved survival rate (p<0.01). Local recurrence rate: R/T alone was 36%; Op was 60% and Op + R/T was 37%. On the basis of these results, the survival rate was increased and the local recurrence rate, decreased by combined therapy. However, treatment outcomes in hypopharyngeal cancer remain unfavorable, even with a combination of surgery and radiation therapy. Alternative approaches should be actively investigated to improve survival.

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