Abstract

Frozen shoulder, or adhesive capsulitis, is a disease of chronic inflammation and fibrosis involving the shoulder joints. The disease is challenging in clinical practice due to painful treatment course, with disease evolution usually lasting weeks or even months, causing significant discomfort and functional loss. Botulinum toxin (BTX) has been discovered to possess abilities in pain management at various clinical diseases. The actual mechanism is still under investigation, and involves inhibition of neurotransmitter release. In addition, BTX is also found to retard process of fibrosis, which is also a key issue in pathogenesis of frozen shoulder. Therefore, we hypothesize that intra-articular injection of BTX can be an effective alternative for treatment of frozen shoulder.

Original languageEnglish
Pages (from-to)305-307
Number of pages3
JournalMedical Hypotheses
Volume77
Issue number2
DOIs
Publication statusPublished - Aug 2011

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Bursitis
Intra-Articular Injections
Shoulder Joint
Botulinum Toxins
Fibrosis
Pain Management
Therapeutics
Neurotransmitter Agents
Chronic Disease
Inflammation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Treatment of frozen shoulder with intra-articular injection of botulinum toxin in shoulder joints. / Chen, Hung Sheng; Chang, Kwang Hwa; Kang, Jiunn Horng; Hsu, Yen Hsia; Hsu, Allen Chia Lin; Chen, Shih Ching.

In: Medical Hypotheses, Vol. 77, No. 2, 08.2011, p. 305-307.

Research output: Contribution to journalArticle

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