Abstract
Background Treating cosmetic tattoos using quality-switched lasers is difficult. Objective We used carbon dioxide ablative fractional resurfacing (CO2 AFR) to remove cosmetic tattoos and examined the pathophysiologic mechanisms involved in this technique in an animal model. Methods and Materials Twelve rats were tattooed on their backs with white and flesh-colored pigments. Half of each tattoo was treated with CO2 AFR (5 sessions at 1-month intervals), and the other half was the untreated control. An independent observer reviewed photographic documentation of clinical response. Serial skin samples obtained at baseline and at various times after laser treatment were evaluated using histologic and immunohistochemical methods. Results Four rats had excellent responses to laser treatment and eight had good responses. White and flesh-colored tattoos had similar clearance rates and tissue reactions. Histologic analysis showed immediate ablation of tattoo pigments in the microscopic ablation zones. Tattoo pigments in the microscopic coagulation zones migrated to the epidermis and became part of the microscopic exudative necrotic debris appearing on day 2 that was exfoliated after 5 days. Increased fibronectin expression around the microscopic treatment zones during the extrusion of tattoo pigments indicated that wound healing facilitates this action. Conclusion CO2 AFR successfully removes cosmetic tattoos.
| Original language | English |
|---|---|
| Pages (from-to) | 571-577 |
| Number of pages | 7 |
| Journal | Dermatologic Surgery |
| Volume | 39 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2013 |
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ASJC Scopus subject areas
- Dermatology
- Surgery
Cite this
Treatment of cosmetic tattoos using carbon dioxide ablative fractional resurfacing in an animal model : A novel method confirmed histopathologically. / Wang, Chia Chen; Huang, Chuen Lin; Sue, Yuh Mou; Lee, Shao Chen; Leu, Fur Jiang.
In: Dermatologic Surgery, Vol. 39, No. 4, 04.2013, p. 571-577.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treatment of cosmetic tattoos using carbon dioxide ablative fractional resurfacing in an animal model
T2 - A novel method confirmed histopathologically
AU - Wang, Chia Chen
AU - Huang, Chuen Lin
AU - Sue, Yuh Mou
AU - Lee, Shao Chen
AU - Leu, Fur Jiang
PY - 2013/4
Y1 - 2013/4
N2 - Background Treating cosmetic tattoos using quality-switched lasers is difficult. Objective We used carbon dioxide ablative fractional resurfacing (CO2 AFR) to remove cosmetic tattoos and examined the pathophysiologic mechanisms involved in this technique in an animal model. Methods and Materials Twelve rats were tattooed on their backs with white and flesh-colored pigments. Half of each tattoo was treated with CO2 AFR (5 sessions at 1-month intervals), and the other half was the untreated control. An independent observer reviewed photographic documentation of clinical response. Serial skin samples obtained at baseline and at various times after laser treatment were evaluated using histologic and immunohistochemical methods. Results Four rats had excellent responses to laser treatment and eight had good responses. White and flesh-colored tattoos had similar clearance rates and tissue reactions. Histologic analysis showed immediate ablation of tattoo pigments in the microscopic ablation zones. Tattoo pigments in the microscopic coagulation zones migrated to the epidermis and became part of the microscopic exudative necrotic debris appearing on day 2 that was exfoliated after 5 days. Increased fibronectin expression around the microscopic treatment zones during the extrusion of tattoo pigments indicated that wound healing facilitates this action. Conclusion CO2 AFR successfully removes cosmetic tattoos.
AB - Background Treating cosmetic tattoos using quality-switched lasers is difficult. Objective We used carbon dioxide ablative fractional resurfacing (CO2 AFR) to remove cosmetic tattoos and examined the pathophysiologic mechanisms involved in this technique in an animal model. Methods and Materials Twelve rats were tattooed on their backs with white and flesh-colored pigments. Half of each tattoo was treated with CO2 AFR (5 sessions at 1-month intervals), and the other half was the untreated control. An independent observer reviewed photographic documentation of clinical response. Serial skin samples obtained at baseline and at various times after laser treatment were evaluated using histologic and immunohistochemical methods. Results Four rats had excellent responses to laser treatment and eight had good responses. White and flesh-colored tattoos had similar clearance rates and tissue reactions. Histologic analysis showed immediate ablation of tattoo pigments in the microscopic ablation zones. Tattoo pigments in the microscopic coagulation zones migrated to the epidermis and became part of the microscopic exudative necrotic debris appearing on day 2 that was exfoliated after 5 days. Increased fibronectin expression around the microscopic treatment zones during the extrusion of tattoo pigments indicated that wound healing facilitates this action. Conclusion CO2 AFR successfully removes cosmetic tattoos.
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U2 - 10.1111/dsu.12104
DO - 10.1111/dsu.12104
M3 - Article
VL - 39
SP - 571
EP - 577
JO - Dermatologic Surgery
JF - Dermatologic Surgery
SN - 1076-0512
IS - 4
ER -