Treatment adherence towards prescribed medications in bipolar-II acute depressed patients: Relationship with cyclothymic temperament and "therapeutic sensation seeking" in response towards subjective intolerance to pain

Michele Fornaro, Domenico De Berardis, Felice Iasevoli, Maria Luisa Pistorio, Emanuela D'Angelo, Sergio Mungo, Matteo Martino, Antonio Ventriglio, Carlo Ignazio Cattaneo, Ettore Favaretto, Alessandro Del Debbio, Anna Romano, Giovanni Ciampa, Mai Elassy, Giulio Perugi, Concetta De Pasquale

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background Treatment adherence (TA) is crucial during almost any phase of bipolar disorder (BD), including type-II (BD-II) acute depression. While a number of issues have been traditionally accounted on the matter, additional factors should be likewise involved, including affective temperaments and some clinically suggestive psychopathological traits whose systematic assessment represents the aim of this study. Methods Two hundred and twenty BD-II acute depressed outpatients were consecutively evaluated using the Structured Clinical Interviews for Diagnostic and Statistical Manual for Mental Disorders-Fourth Edition Axis-I and II Disorders, Hamilton scales for Depression and Anxiety, Temperament Evaluation of the Memphis Pisa Paris San Diego-Auto-questionnaire- 110-item, Visual Analogue Scale (VAS), Zuckerman's Sensation-Seeking Scale-Form-V (SSS-V), Barratt's Impulsivity Scale-11-item, State-Trait Anxiety Inventory modules, Severity module of the Clinical Global Impression Scale for BD, Morisky 8-Item Medication Adherence Scale (MMAS-8) and the Clinician Rating Scale (CRS). Patients were divided into non-adherent vs. treatment-adherent cases depending on MMAS-8+CRS scores. Results In the TA- group, higher VAS and cyclothymic temperament scores were highly correlated (r=.699; p≤.001). Those latter scores, along with SSS-V scores and the occurrence of lifetime addiction to painkiller and/or homeopathic medications available over the counter defined a "therapeutic sensation seeking" pattern allowing to correctly classify as much as 93.9% [Exp(B)=3.490; p≤.001] of TA - cases (49/220). Limits Lack of objective TA measures and systematic pharmacological record; recall bias on some diagnoses; and relatively small sample size. Conclusions Stating the burden of TA in BD, additional studies on this regard are aimed, ideally contributing to enhance the management of BD itself.

Original languageEnglish
Pages (from-to)596-604
Number of pages9
JournalJournal of Affective Disorders
Volume151
Issue number2
DOIs
Publication statusPublished - Nov 2013
Externally publishedYes

Keywords

  • Acute depression
  • Bipolar disorder
  • Cyclothymic temperament
  • Sensation seeking
  • Treatment adherence

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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    Fornaro, M., De Berardis, D., Iasevoli, F., Pistorio, M. L., D'Angelo, E., Mungo, S., Martino, M., Ventriglio, A., Cattaneo, C. I., Favaretto, E., Del Debbio, A., Romano, A., Ciampa, G., Elassy, M., Perugi, G., & De Pasquale, C. (2013). Treatment adherence towards prescribed medications in bipolar-II acute depressed patients: Relationship with cyclothymic temperament and "therapeutic sensation seeking" in response towards subjective intolerance to pain. Journal of Affective Disorders, 151(2), 596-604. https://doi.org/10.1016/j.jad.2013.07.004