Treating intracranial abscesses in rats with stereotactic injection of biodegradable vancomycin-embedded microparticles

Yuan Yun Tseng, Ching Wei Kao, Kuo Sheng Liu, Ya Ling Tang, Yen Wei Liu, Shih Jung Liu

Research output: Contribution to journalArticle

Abstract

Brain abscesses are emergent and life-threating despite advances in modern neurosurgical techniques and antibiotics. The present study explores the efficacy of vancomycin embedded to 50:50 poly(lactic-co-glycolide acid) (PLGA) microparticles in the treatment of brain abscess. The vancomycin embedded microparticles (VMPs) were stereotactically introduced into the cerebral parenchyma in Staphylococcus aureus bacteria-induced brain abscess-bearing rats. Experimental rats were divided into three groups: group A (n = 13; no treatment), group B (n = 14; daily vancomycin injection (5 mg intraperitoneally), and group C (n = 12; stereotactic introduction of VMPs into the abscess cavity). Group C exhibited no inflammatory response and significantly increased survival and reduced mean abscess volumes (p <0.001) at the eighth week, compared with other groups. Vancomycin delivery via a biodegradable PLGA vehicle can easily attain Area Under the Curve (AUC)/minimum inhibitory concentration (MIC) ratios of ≥400, and strengthens the therapeutic efficacy of antibiotics without provoking any potential toxicity. Biodegradable VMPs are a safe and sustainable drug delivery vehicle for the treatment of brain abscess.

Original languageEnglish
Article number91
JournalPharmaceutics
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 2020

Keywords

  • Brain abscess
  • Drug delivery
  • Electrospraying
  • Poly(lactide-co-glycolide acid)
  • Stereotactic
  • Vancomycin

ASJC Scopus subject areas

  • Pharmaceutical Science

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