Transtubular potassium gradient predicts kidney function impairment after adrenalectomy in primary aldosteronism

Hung Wei Liao, Shuo Meng Wang, Chieh Kai Chan, Yen Hung Lin, Po Chih Lin, Chen Hsun Ho, Yu Chun Liu, Shih Chieh Jeff Chueh, Vin Cent Wu, Tai Shuan Lai, Shao Yu Yang, Kao Lang Liu, Chin Chen Chang, Bo Chiag Lee, Kuo How Huang, Lian Yu Lin, Shih Cheng Liao, Ruoh Fang Yen, Ching Chu Lu, Leay Kiaw ErYa Hui Hu, Chia Hui Chang, Che Hsiung Wu, Yao Chou Tsai, Shih Chieh Jeff Chueh, Wei Chieh Huang, Ying Ying Chen, Kwan Dun Wu

Research output: Contribution to journalArticlepeer-review


Background: In primary aldosteronism (PA), kidney function impairment could be concealed by relative hyperfiltration and emerge after adrenalectomy. We hypothesized transtubular gradient potassium gradient (TTKG), a kidney aldosterone bioactivity indicator, could correlate to end organ damage and forecast kidney function impairment after adrenalectomy. Methods: In the present prospective study, we enrolled lateralized PA patients who underwent adrenalectomy and were followed up 12 months after operation in the Taiwan Primary Aldosteronism Investigation (TAIPAI) registry from 2010 to 2018. The clinical outcome was kidney function impairment, defined as estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2 at 12 months after adrenalectomy. End organ damage is determined by microalbuminuria and left ventricular mass. Results: In total, 323 patients [mean, 50.8 ± 10.9 years old; female 178 (55.1%)] were enrolled. Comparing pre-operation and post-operation data, systolic blood pressure, serum aldosterone, urinary albumin to creatinine ratio and eGFR decreased. TTKG ⩾ 4.9 correlated with pre-operative urinary albumin to creatinine ratio >50 mg/g [odds ratio (OR) = 2.42; p = 0.034] and left ventricular mass (B = 20.10; p = 0.018). Multivariate logistic regression analysis demonstrated that TTKG ⩾ 4.9 could predict concealed chronic kidney disease (OR = 5.42; p = 0.011) and clinical success (OR = 2.90, p = 0.017) at 12 months after adrenalectomy. Conclusions: TTKG could predict concealed kidney function impairment and cure of hypertension in PA patients after adrenalectomy. TTKG more than 4.9 as an adverse surrogate of aldosterone and hypokalaemia correlated with pre-operative end organ damage in terms of high proteinuria and cardiac hypertrophy.

Original languageEnglish
JournalTherapeutic Advances in Chronic Disease
Publication statusPublished - 2020


  • adrenalectomy
  • kidney function impairment
  • primary aldosteronism
  • transtubular potassium gradient

ASJC Scopus subject areas

  • Medicine (miscellaneous)


Dive into the research topics of 'Transtubular potassium gradient predicts kidney function impairment after adrenalectomy in primary aldosteronism'. Together they form a unique fingerprint.

Cite this