Transplantation of related histocompatible marrow and peripheral blood stem cells in a patient with severe combined immunodeficiency and disseminated BCG infection

Giun Yi Hung; Tzeon Jye Chiou; Ching Yuang Lin; Liang Tsai Hsiao; Po Min Chen; Betau Hwang

Transplantation of related histocompatible marrow and peripheral blood stem cells in a patient with severe combined immunodeficiency and disseminated BCG infection

Giun Yi Hung, Tzeon Jye Chiou, Ching Yuang Lin, Liang Tsai Hsiao, Po Min Chen, Betau Hwang

Research output: Contribution to journal › Article › peer-review

Abstract

We report the results of allogeneic bone marrow transplantation (BMT) in a 15-month-old boy with severe combined immunodeficiency (SCID) complicated by disseminated Bacillus Calmette-Guerin (BCG) infection. Slow immunological recovery after BMT is considered to be associated with prolonged BCG infection. After one booster dose of allogeneic peripheral blood stem cell transplantation (PBSCT), there was still little improvement in immune reconstitution. The patient finally expired because of failure to achieve a functioning immune system after BMT and septic shock.

Original language	English
Pages (from-to)	72-75
Number of pages	4
Journal	Journal of the Chinese Medical Association
Volume	66
Issue number	1
Publication status	Published - Jan 2003
Externally published	Yes

Keywords

BCG infection
Bone marrow transplantation
Peripheral blood stem cell transplantation
Severe combined immunodeficiency

ASJC Scopus subject areas

Medicine(all)

Cite this

Transplantation of related histocompatible marrow and peripheral blood stem cells in a patient with severe combined immunodeficiency and disseminated BCG infection. / Hung, Giun Yi; Chiou, Tzeon Jye; Lin, Ching Yuang et al.

In: Journal of the Chinese Medical Association, Vol. 66, No. 1, 01.2003, p. 72-75.

Research output: Contribution to journal › Article › peer-review

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AU - Hsiao, Liang Tsai

AU - Chen, Po Min

AU - Hwang, Betau

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AB - We report the results of allogeneic bone marrow transplantation (BMT) in a 15-month-old boy with severe combined immunodeficiency (SCID) complicated by disseminated Bacillus Calmette-Guerin (BCG) infection. Slow immunological recovery after BMT is considered to be associated with prolonged BCG infection. After one booster dose of allogeneic peripheral blood stem cell transplantation (PBSCT), there was still little improvement in immune reconstitution. The patient finally expired because of failure to achieve a functioning immune system after BMT and septic shock.

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Transplantation of related histocompatible marrow and peripheral blood stem cells in a patient with severe combined immunodeficiency and disseminated BCG infection

Abstract

Keywords

ASJC Scopus subject areas

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